| Full name: X-ray repair cross complementing 5 | Alias Symbol: KU80|KARP-1|Ku86|KUB2 | ||
| Type: protein-coding gene | Cytoband: 2q35 | ||
| Entrez ID: 7520 | HGNC ID: HGNC:12833 | Ensembl Gene: ENSG00000079246 | OMIM ID: 194364 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of XRCC5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | XRCC5 | 7520 | 208642_s_at | -0.1351 | 0.7766 | |
| GSE20347 | XRCC5 | 7520 | 208642_s_at | -0.1532 | 0.2220 | |
| GSE23400 | XRCC5 | 7520 | 208642_s_at | 0.2648 | 0.0000 | |
| GSE26886 | XRCC5 | 7520 | 208642_s_at | 0.0436 | 0.6881 | |
| GSE29001 | XRCC5 | 7520 | 208642_s_at | 0.1629 | 0.3188 | |
| GSE38129 | XRCC5 | 7520 | 208642_s_at | 0.0608 | 0.6506 | |
| GSE45670 | XRCC5 | 7520 | 208642_s_at | 0.1050 | 0.3441 | |
| GSE53622 | XRCC5 | 7520 | 13198 | 0.2720 | 0.0000 | |
| GSE53624 | XRCC5 | 7520 | 13198 | 0.2296 | 0.0012 | |
| GSE63941 | XRCC5 | 7520 | 208642_s_at | 0.1069 | 0.6526 | |
| GSE77861 | XRCC5 | 7520 | 208642_s_at | 0.1647 | 0.4607 | |
| GSE97050 | XRCC5 | 7520 | A_24_P345498 | 0.5027 | 0.1318 | |
| SRP007169 | XRCC5 | 7520 | RNAseq | 0.7645 | 0.0771 | |
| SRP008496 | XRCC5 | 7520 | RNAseq | 1.0250 | 0.0007 | |
| SRP064894 | XRCC5 | 7520 | RNAseq | -0.0570 | 0.6066 | |
| SRP133303 | XRCC5 | 7520 | RNAseq | 0.1177 | 0.3403 | |
| SRP159526 | XRCC5 | 7520 | RNAseq | 0.0181 | 0.8955 | |
| SRP193095 | XRCC5 | 7520 | RNAseq | -0.2830 | 0.0113 | |
| SRP219564 | XRCC5 | 7520 | RNAseq | -0.3498 | 0.2192 | |
| TCGA | XRCC5 | 7520 | RNAseq | 0.0582 | 0.1363 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by XRCC5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of XRCC5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | XRCC5 | 7520 | 1 | 13 | 16 | |
| GSE20123 | XRCC5 | 7520 | 1 | 13 | 16 | |
| GSE43470 | XRCC5 | 7520 | 0 | 7 | 36 | |
| GSE46452 | XRCC5 | 7520 | 0 | 5 | 54 | |
| GSE47630 | XRCC5 | 7520 | 4 | 5 | 31 | |
| GSE54993 | XRCC5 | 7520 | 0 | 3 | 67 | |
| GSE54994 | XRCC5 | 7520 | 8 | 9 | 36 | |
| GSE60625 | XRCC5 | 7520 | 0 | 3 | 8 | |
| GSE74703 | XRCC5 | 7520 | 0 | 6 | 30 | |
| GSE74704 | XRCC5 | 7520 | 1 | 7 | 12 | |
| TCGA | XRCC5 | 7520 | 11 | 28 | 57 |
Total number of gains: 26; Total number of losses: 99; Total Number of normals: 363.
Somatic mutations of XRCC5:
Generating mutation plots.
Highly correlated genes for XRCC5:
Showing top 20/622 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| XRCC5 | SGMS1 | 0.786011 | 3 | 0 | 3 |
| XRCC5 | GMPR2 | 0.751793 | 3 | 0 | 3 |
| XRCC5 | ATF1 | 0.75173 | 3 | 0 | 3 |
| XRCC5 | FRMD6 | 0.743463 | 4 | 0 | 3 |
| XRCC5 | RLF | 0.738889 | 3 | 0 | 3 |
| XRCC5 | VPS25 | 0.726514 | 3 | 0 | 3 |
| XRCC5 | ATP6V0D1 | 0.716428 | 3 | 0 | 3 |
| XRCC5 | HLA-DMB | 0.712213 | 3 | 0 | 3 |
| XRCC5 | TMX3 | 0.71183 | 3 | 0 | 3 |
| XRCC5 | PAIP2 | 0.710842 | 3 | 0 | 3 |
| XRCC5 | PSMC1 | 0.710081 | 4 | 0 | 3 |
| XRCC5 | GMCL1 | 0.705986 | 3 | 0 | 3 |
| XRCC5 | C12orf57 | 0.705541 | 3 | 0 | 3 |
| XRCC5 | NRBF2 | 0.7044 | 4 | 0 | 3 |
| XRCC5 | SLIRP | 0.703228 | 3 | 0 | 3 |
| XRCC5 | IMPACT | 0.700129 | 5 | 0 | 5 |
| XRCC5 | LRIG3 | 0.699928 | 3 | 0 | 3 |
| XRCC5 | CHMP5 | 0.698296 | 4 | 0 | 3 |
| XRCC5 | TMEM117 | 0.68864 | 3 | 0 | 3 |
| XRCC5 | COPZ1 | 0.687231 | 3 | 0 | 3 |
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