| Full name: alcohol dehydrogenase 1C (class I), gamma polypeptide | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 4q23 | ||
| Entrez ID: 126 | HGNC ID: HGNC:251 | Ensembl Gene: ENSG00000248144 | OMIM ID: 103730 |
| Drug and gene relationship at DGIdb | |||
Expression of ADH1C:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ADH1C | 126 | 206262_at | -1.0245 | 0.3917 | |
| GSE20347 | ADH1C | 126 | 206262_at | -0.0499 | 0.9165 | |
| GSE23400 | ADH1C | 126 | 206262_at | 0.1753 | 0.1904 | |
| GSE26886 | ADH1C | 126 | 206262_at | -1.7404 | 0.0000 | |
| GSE29001 | ADH1C | 126 | 206262_at | -0.5497 | 0.4362 | |
| GSE38129 | ADH1C | 126 | 206262_at | -0.7656 | 0.0735 | |
| GSE45670 | ADH1C | 126 | 206262_at | -1.0093 | 0.1473 | |
| GSE53622 | ADH1C | 126 | 102157 | -4.2136 | 0.0000 | |
| GSE53624 | ADH1C | 126 | 102157 | -3.9982 | 0.0000 | |
| GSE63941 | ADH1C | 126 | 206262_at | 0.8427 | 0.6839 | |
| GSE77861 | ADH1C | 126 | 206262_at | -0.3697 | 0.6337 | |
| GSE97050 | ADH1C | 126 | A_23_P81158 | -0.8516 | 0.1911 | |
| SRP064894 | ADH1C | 126 | RNAseq | 0.1036 | 0.8915 | |
| SRP133303 | ADH1C | 126 | RNAseq | 2.0443 | 0.0881 | |
| SRP159526 | ADH1C | 126 | RNAseq | -1.0548 | 0.3827 | |
| TCGA | ADH1C | 126 | RNAseq | -1.8082 | 0.0298 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by ADH1C expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ADH1C:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ADH1C | 126 | 0 | 12 | 18 | |
| GSE20123 | ADH1C | 126 | 0 | 12 | 18 | |
| GSE43470 | ADH1C | 126 | 0 | 14 | 29 | |
| GSE46452 | ADH1C | 126 | 1 | 36 | 22 | |
| GSE47630 | ADH1C | 126 | 0 | 20 | 20 | |
| GSE54993 | ADH1C | 126 | 9 | 0 | 61 | |
| GSE54994 | ADH1C | 126 | 1 | 11 | 41 | |
| GSE60625 | ADH1C | 126 | 0 | 3 | 8 | |
| GSE74703 | ADH1C | 126 | 0 | 12 | 24 | |
| GSE74704 | ADH1C | 126 | 0 | 6 | 14 | |
| TCGA | ADH1C | 126 | 8 | 41 | 47 |
Total number of gains: 19; Total number of losses: 167; Total Number of normals: 302.
Somatic mutations of ADH1C:
Generating mutation plots.
Highly correlated genes for ADH1C:
Showing top 20/1149 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ADH1C | CLEC3B | 0.811896 | 3 | 0 | 3 |
| ADH1C | PPM1L | 0.773735 | 5 | 0 | 5 |
| ADH1C | TCF21 | 0.765233 | 4 | 0 | 4 |
| ADH1C | NR2F1 | 0.762503 | 3 | 0 | 3 |
| ADH1C | FHL1 | 0.760917 | 4 | 0 | 4 |
| ADH1C | CYP21A2 | 0.742935 | 3 | 0 | 3 |
| ADH1C | THRAP3 | 0.738667 | 3 | 0 | 3 |
| ADH1C | ATF1 | 0.738256 | 3 | 0 | 3 |
| ADH1C | SORCS1 | 0.738233 | 4 | 0 | 4 |
| ADH1C | FBXO3 | 0.735462 | 3 | 0 | 3 |
| ADH1C | MAN1C1 | 0.733684 | 4 | 0 | 4 |
| ADH1C | CCDC25 | 0.732016 | 3 | 0 | 3 |
| ADH1C | USP33 | 0.730863 | 3 | 0 | 3 |
| ADH1C | CCDC159 | 0.728401 | 4 | 0 | 4 |
| ADH1C | PODN | 0.726345 | 4 | 0 | 4 |
| ADH1C | BRK1 | 0.725902 | 5 | 0 | 5 |
| ADH1C | NME5 | 0.723126 | 4 | 0 | 4 |
| ADH1C | SAP18 | 0.722719 | 4 | 0 | 4 |
| ADH1C | FAXDC2 | 0.722547 | 3 | 0 | 3 |
| ADH1C | EID1 | 0.721517 | 3 | 0 | 3 |
For details and further investigation, click here
