| Full name: activating transcription factor 3 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1q32.3 | ||
| Entrez ID: 467 | HGNC ID: HGNC:785 | Ensembl Gene: ENSG00000162772 | OMIM ID: 603148 |
| Drug and gene relationship at DGIdb | |||
ATF3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05166 | HTLV-I infection |
Expression of ATF3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ATF3 | 467 | 202672_s_at | -0.6643 | 0.7291 | |
| GSE20347 | ATF3 | 467 | 202672_s_at | 0.4061 | 0.5005 | |
| GSE23400 | ATF3 | 467 | 202672_s_at | -0.3035 | 0.2176 | |
| GSE26886 | ATF3 | 467 | 202672_s_at | 1.5045 | 0.0117 | |
| GSE29001 | ATF3 | 467 | 202672_s_at | -0.8527 | 0.2716 | |
| GSE38129 | ATF3 | 467 | 202672_s_at | 0.0873 | 0.8760 | |
| GSE45670 | ATF3 | 467 | 202672_s_at | -0.5961 | 0.3331 | |
| GSE53622 | ATF3 | 467 | 100248 | -0.4262 | 0.0314 | |
| GSE53624 | ATF3 | 467 | 100248 | -0.5394 | 0.0000 | |
| GSE63941 | ATF3 | 467 | 202672_s_at | 1.8655 | 0.2015 | |
| GSE77861 | ATF3 | 467 | 202672_s_at | 1.1558 | 0.2928 | |
| GSE97050 | ATF3 | 467 | A_33_P3214105 | -0.5775 | 0.4212 | |
| SRP007169 | ATF3 | 467 | RNAseq | 0.9835 | 0.0393 | |
| SRP008496 | ATF3 | 467 | RNAseq | 0.4804 | 0.3082 | |
| SRP064894 | ATF3 | 467 | RNAseq | -0.2033 | 0.6341 | |
| SRP133303 | ATF3 | 467 | RNAseq | -0.0314 | 0.9510 | |
| SRP159526 | ATF3 | 467 | RNAseq | 0.6566 | 0.3396 | |
| SRP193095 | ATF3 | 467 | RNAseq | 0.9508 | 0.0823 | |
| TCGA | ATF3 | 467 | RNAseq | -0.2315 | 0.0632 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by ATF3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ATF3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ATF3 | 467 | 10 | 0 | 20 | |
| GSE20123 | ATF3 | 467 | 10 | 0 | 20 | |
| GSE43470 | ATF3 | 467 | 8 | 1 | 34 | |
| GSE46452 | ATF3 | 467 | 3 | 1 | 55 | |
| GSE47630 | ATF3 | 467 | 15 | 0 | 25 | |
| GSE54993 | ATF3 | 467 | 0 | 6 | 64 | |
| GSE54994 | ATF3 | 467 | 13 | 0 | 40 | |
| GSE60625 | ATF3 | 467 | 0 | 0 | 11 | |
| GSE74703 | ATF3 | 467 | 8 | 1 | 27 | |
| GSE74704 | ATF3 | 467 | 4 | 0 | 16 | |
| TCGA | ATF3 | 467 | 46 | 3 | 47 |
Total number of gains: 117; Total number of losses: 12; Total Number of normals: 359.
Somatic mutations of ATF3:
Generating mutation plots.
Highly correlated genes for ATF3:
Showing top 20/115 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ATF3 | RAB6B | 0.766801 | 3 | 0 | 3 |
| ATF3 | CSRNP1 | 0.737286 | 5 | 0 | 5 |
| ATF3 | NR4A1 | 0.730906 | 8 | 0 | 8 |
| ATF3 | FOSB | 0.712848 | 13 | 0 | 12 |
| ATF3 | SOX10 | 0.681147 | 4 | 0 | 3 |
| ATF3 | TSPAN18 | 0.671874 | 3 | 0 | 3 |
| ATF3 | PNPLA2 | 0.662654 | 3 | 0 | 3 |
| ATF3 | GABBR1 | 0.659552 | 4 | 0 | 3 |
| ATF3 | EGR3 | 0.659246 | 9 | 0 | 7 |
| ATF3 | NRK | 0.658064 | 3 | 0 | 3 |
| ATF3 | BTG2 | 0.653199 | 11 | 0 | 9 |
| ATF3 | SH3GL2 | 0.651548 | 4 | 0 | 3 |
| ATF3 | ANKRD40 | 0.650917 | 4 | 0 | 4 |
| ATF3 | PPP1R15A | 0.64383 | 11 | 0 | 10 |
| ATF3 | EPX | 0.637539 | 3 | 0 | 3 |
| ATF3 | RNF122 | 0.637042 | 5 | 0 | 4 |
| ATF3 | NR4A2 | 0.633655 | 12 | 0 | 10 |
| ATF3 | PTPDC1 | 0.627388 | 4 | 0 | 4 |
| ATF3 | TSPYL2 | 0.621681 | 4 | 0 | 3 |
| ATF3 | ZBED3 | 0.618427 | 4 | 0 | 3 |
For details and further investigation, click here
