| Full name: FosB proto-oncogene, AP-1 transcription factor subunit | Alias Symbol: G0S3|GOSB|GOS3|AP-1|MGC42291|DKFZp686C0818 | ||
| Type: protein-coding gene | Cytoband: 19q13.32 | ||
| Entrez ID: 2354 | HGNC ID: HGNC:3797 | Ensembl Gene: ENSG00000125740 | OMIM ID: 164772 |
| Drug and gene relationship at DGIdb | |||
FOSB involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04380 | Osteoclast differentiation | |
| hsa05030 | Cocaine addiction | |
| hsa05031 | Amphetamine addiction | |
| hsa05034 | Alcoholism |
Expression of FOSB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FOSB | 2354 | 202768_at | -1.3882 | 0.3435 | |
| GSE20347 | FOSB | 2354 | 202768_at | -1.1018 | 0.0317 | |
| GSE23400 | FOSB | 2354 | 202768_at | -1.3228 | 0.0000 | |
| GSE26886 | FOSB | 2354 | 202768_at | 0.8704 | 0.1004 | |
| GSE29001 | FOSB | 2354 | 202768_at | -1.7763 | 0.0057 | |
| GSE38129 | FOSB | 2354 | 202768_at | -1.5768 | 0.0012 | |
| GSE45670 | FOSB | 2354 | 202768_at | -1.7566 | 0.0067 | |
| GSE53622 | FOSB | 2354 | 10373 | -1.3294 | 0.0000 | |
| GSE53624 | FOSB | 2354 | 10373 | -1.1518 | 0.0000 | |
| GSE63941 | FOSB | 2354 | 202768_at | 0.2563 | 0.5037 | |
| GSE77861 | FOSB | 2354 | 202768_at | 0.0617 | 0.9639 | |
| GSE97050 | FOSB | 2354 | A_23_P429998 | -0.8186 | 0.3964 | |
| SRP007169 | FOSB | 2354 | RNAseq | -2.7626 | 0.0003 | |
| SRP008496 | FOSB | 2354 | RNAseq | -2.8642 | 0.0000 | |
| SRP064894 | FOSB | 2354 | RNAseq | -0.7828 | 0.1443 | |
| SRP133303 | FOSB | 2354 | RNAseq | -1.3680 | 0.0864 | |
| SRP159526 | FOSB | 2354 | RNAseq | -0.4056 | 0.6158 | |
| SRP193095 | FOSB | 2354 | RNAseq | 0.6228 | 0.3395 | |
| TCGA | FOSB | 2354 | RNAseq | -0.5068 | 0.0030 |
Upregulated datasets: 0; Downregulated datasets: 9.
Survival by FOSB expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FOSB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FOSB | 2354 | 4 | 5 | 21 | |
| GSE20123 | FOSB | 2354 | 4 | 4 | 22 | |
| GSE43470 | FOSB | 2354 | 3 | 11 | 29 | |
| GSE46452 | FOSB | 2354 | 45 | 1 | 13 | |
| GSE47630 | FOSB | 2354 | 8 | 6 | 26 | |
| GSE54993 | FOSB | 2354 | 17 | 4 | 49 | |
| GSE54994 | FOSB | 2354 | 6 | 12 | 35 | |
| GSE60625 | FOSB | 2354 | 9 | 0 | 2 | |
| GSE74703 | FOSB | 2354 | 3 | 7 | 26 | |
| GSE74704 | FOSB | 2354 | 4 | 2 | 14 | |
| TCGA | FOSB | 2354 | 15 | 16 | 65 |
Total number of gains: 118; Total number of losses: 68; Total Number of normals: 302.
Somatic mutations of FOSB:
Generating mutation plots.
Highly correlated genes for FOSB:
Showing top 20/250 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FOSB | FOS | 0.716082 | 13 | 0 | 13 |
| FOSB | ATF3 | 0.712848 | 13 | 0 | 12 |
| FOSB | NR4A2 | 0.68909 | 11 | 0 | 10 |
| FOSB | ANO5 | 0.685048 | 3 | 0 | 3 |
| FOSB | ZFP36 | 0.680343 | 10 | 0 | 8 |
| FOSB | EGR1 | 0.678116 | 13 | 0 | 11 |
| FOSB | CTNNA3 | 0.674116 | 4 | 0 | 4 |
| FOSB | DUSP2 | 0.671941 | 5 | 0 | 5 |
| FOSB | DUSP1 | 0.670796 | 13 | 0 | 12 |
| FOSB | NR4A1 | 0.66505 | 9 | 0 | 7 |
| FOSB | SLC35F1 | 0.660598 | 4 | 0 | 3 |
| FOSB | JUND | 0.659481 | 12 | 0 | 11 |
| FOSB | MRVI1 | 0.657733 | 4 | 0 | 4 |
| FOSB | SOX10 | 0.655495 | 4 | 0 | 3 |
| FOSB | JUN | 0.65156 | 13 | 0 | 12 |
| FOSB | PRSS37 | 0.647954 | 3 | 0 | 3 |
| FOSB | BTG2 | 0.646912 | 11 | 0 | 10 |
| FOSB | SLC25A25 | 0.644154 | 6 | 0 | 5 |
| FOSB | LRCH1 | 0.64367 | 4 | 0 | 3 |
| FOSB | UBXN10 | 0.638496 | 3 | 0 | 3 |
For details and further investigation, click here
