Full name: activating transcription factor 4	Alias Symbol: TAXREB67|CREB-2
Type: protein-coding gene	Cytoband: 22q13.1
Entrez ID: 468	HGNC ID: HGNC:786	Ensembl Gene: ENSG00000128272	OMIM ID: 604064
Drug and gene relationship at DGIdb
Screen Evidence: Knocking out of this gene by CRIPR/Cas9 screen found 51/325 cell lines had fitness change in Project Score. Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

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ATF4 involved pathways:

KEGG pathway	Description	View
hsa04010	MAPK signaling pathway	View
hsa04022	cGMP-PKG signaling pathway	View
hsa04151	PI3K-Akt signaling pathway	View
hsa04210	Apoptosis	View
hsa04261	Adrenergic signaling in cardiomyocytes	View
hsa04668	TNF signaling pathway	View
hsa04720	Long-term potentiation	View
hsa04722	Neurotrophin signaling pathway	View
hsa04725	Cholinergic synapse	View
hsa04728	Dopaminergic synapse	View
hsa04911	Insulin secretion	View
hsa04912	GnRH signaling pathway	View
hsa04915	Estrogen signaling pathway	View
hsa04918	Thyroid hormone synthesis	View
hsa04922	Glucagon signaling pathway	View
hsa04925	Aldosterone synthesis and secretion	View
hsa04932	Non-alcoholic fatty liver disease (NAFLD)	View
hsa05030	Cocaine addiction	View
hsa05031	Amphetamine addiction	View
hsa05034	Alcoholism	View
hsa05161	Hepatitis B	View
hsa05166	HTLV-I infection	View
hsa05215	Prostate cancer	View

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Expression of ATF4:

 

Dataset	Gene	EntrezID	Probe	Log2FC	Adj.pValue	Expression
GSE17351	ATF4	468	200779_at	-0.1700	0.7017	Show
GSE20347	ATF4	468	200779_at	0.0637	0.6495	Show
GSE23400	ATF4	468	200779_at	-0.0684	0.2924	Show
GSE26886	ATF4	468	200779_at	0.2435	0.0839	Show
GSE29001	ATF4	468	200779_at	-0.1277	0.7446	Show
GSE38129	ATF4	468	200779_at	-0.0305	0.8174	Show
GSE45670	ATF4	468	200779_at	-0.0792	0.6184	Show
GSE53622	ATF4	468	103105	-0.2733	0.0001	Show
GSE53624	ATF4	468	103105	-0.1109	0.0463	Show
GSE63941	ATF4	468	200779_at	0.4580	0.4097	Show
GSE77861	ATF4	468	200779_at	0.6100	0.0203	Show
GSE97050	ATF4	468	A_23_P120933	-0.6928	0.0867	Show
SRP007169	ATF4	468	RNAseq	-0.8767	0.0197	Show
SRP008496	ATF4	468	RNAseq	-0.6855	0.0027	Show
SRP064894	ATF4	468	RNAseq	0.0543	0.7637	Show
SRP133303	ATF4	468	RNAseq	0.0482	0.8122	Show
SRP159526	ATF4	468	RNAseq	-0.0475	0.8659	Show
SRP193095	ATF4	468	RNAseq	-0.0977	0.4447	Show
SRP219564	ATF4	468	RNAseq	-0.3053	0.4297	Show
TCGA	ATF4	468	RNAseq	-0.1516	0.0001	Show

Upregulated datasets: 0; Downregulated datasets: 0.  Download Data

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Survival by ATF4 expression:

 

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Copy number change of ATF4:

 

Dataset	Gene	EntrezID	Gain	Loss	Normal	Detail
GSE15526	ATF4	468	6	5	19	Show
GSE20123	ATF4	468	6	4	20	Show
GSE43470	ATF4	468	5	6	32	Show
GSE46452	ATF4	468	32	2	25	Show
GSE47630	ATF4	468	9	4	27	Show
GSE54993	ATF4	468	3	6	61	Show
GSE54994	ATF4	468	10	7	36	Show
GSE60625	ATF4	468	5	0	6	Show
GSE74703	ATF4	468	5	4	27	Show
GSE74704	ATF4	468	3	2	15	Show
TCGA	ATF4	468	27	15	54	Show

Total number of gains: 111; Total number of losses: 55; Total Number of normals: 322.  Download Data

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Somatic mutations of ATF4:

 

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Highly correlated genes for ATF4:

 

Showing top 20/176 corelated genes with mean PCC>0.5.

Gene1	Gene2	Mean PCC	Num. Datasets	Num. PCC<0	Num. PCC>0.5
ATF4	PSMB7	0.69267	3	0	3
ATF4	SPTSSA	0.682811	3	0	3
ATF4	FRMD3	0.666475	3	0	3
ATF4	TUBE1	0.656387	3	0	3
ATF4	ADNP2	0.656105	4	0	3
ATF4	GADD45A	0.653484	3	0	3
ATF4	DDIT3	0.651057	8	0	6
ATF4	EXTL3	0.650997	3	0	3
ATF4	MOB3C	0.643039	3	0	3
ATF4	COCH	0.642867	3	0	3
ATF4	RPS6KC1	0.641861	3	0	3
ATF4	QSOX2	0.640845	3	0	3
ATF4	KANSL2	0.635046	3	0	3
ATF4	COPS2	0.635011	3	0	3
ATF4	ZNF417	0.630676	3	0	3
ATF4	PKN1	0.628141	4	0	3
ATF4	RBM38	0.624876	4	0	3
ATF4	INO80	0.624754	3	0	3
ATF4	ABCG1	0.623289	4	0	3
ATF4	FAM168B	0.621805	6	0	5

For details and further investigation, click here