| Full name: ataxin 1 | Alias Symbol: D6S504E|ATX1 | ||
| Type: protein-coding gene | Cytoband: 6p22.3 | ||
| Entrez ID: 6310 | HGNC ID: HGNC:10548 | Ensembl Gene: ENSG00000124788 | OMIM ID: 601556 |
| Drug and gene relationship at DGIdb | |||
Expression of ATXN1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ATXN1 | 6310 | 203232_s_at | -0.0222 | 0.9776 | |
| GSE20347 | ATXN1 | 6310 | 203232_s_at | -0.3521 | 0.0916 | |
| GSE23400 | ATXN1 | 6310 | 203232_s_at | 0.1909 | 0.0683 | |
| GSE26886 | ATXN1 | 6310 | 203232_s_at | 0.1490 | 0.5239 | |
| GSE29001 | ATXN1 | 6310 | 203232_s_at | -0.1987 | 0.6067 | |
| GSE38129 | ATXN1 | 6310 | 203232_s_at | -0.3671 | 0.0229 | |
| GSE45670 | ATXN1 | 6310 | 203232_s_at | -0.3138 | 0.0770 | |
| GSE53622 | ATXN1 | 6310 | 60895 | -0.1070 | 0.2547 | |
| GSE53624 | ATXN1 | 6310 | 60895 | -0.0749 | 0.3098 | |
| GSE63941 | ATXN1 | 6310 | 203232_s_at | -0.4803 | 0.4182 | |
| GSE77861 | ATXN1 | 6310 | 203232_s_at | 0.0285 | 0.9568 | |
| GSE97050 | ATXN1 | 6310 | A_33_P3409099 | 0.0505 | 0.9025 | |
| SRP007169 | ATXN1 | 6310 | RNAseq | 0.6606 | 0.0276 | |
| SRP008496 | ATXN1 | 6310 | RNAseq | 0.8272 | 0.0004 | |
| SRP064894 | ATXN1 | 6310 | RNAseq | 0.3499 | 0.0728 | |
| SRP133303 | ATXN1 | 6310 | RNAseq | 0.2417 | 0.1757 | |
| SRP159526 | ATXN1 | 6310 | RNAseq | -0.0277 | 0.8698 | |
| SRP193095 | ATXN1 | 6310 | RNAseq | 0.0290 | 0.7915 | |
| SRP219564 | ATXN1 | 6310 | RNAseq | -0.3393 | 0.4301 | |
| TCGA | ATXN1 | 6310 | RNAseq | -0.0667 | 0.2447 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ATXN1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ATXN1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ATXN1 | 6310 | 3 | 5 | 22 | |
| GSE20123 | ATXN1 | 6310 | 3 | 5 | 22 | |
| GSE43470 | ATXN1 | 6310 | 9 | 0 | 34 | |
| GSE46452 | ATXN1 | 6310 | 1 | 10 | 48 | |
| GSE47630 | ATXN1 | 6310 | 7 | 7 | 26 | |
| GSE54993 | ATXN1 | 6310 | 1 | 1 | 68 | |
| GSE54994 | ATXN1 | 6310 | 10 | 3 | 40 | |
| GSE60625 | ATXN1 | 6310 | 0 | 1 | 10 | |
| GSE74703 | ATXN1 | 6310 | 8 | 0 | 28 | |
| GSE74704 | ATXN1 | 6310 | 2 | 2 | 16 | |
| TCGA | ATXN1 | 6310 | 16 | 26 | 54 |
Total number of gains: 60; Total number of losses: 60; Total Number of normals: 368.
Somatic mutations of ATXN1:
Generating mutation plots.
Highly correlated genes for ATXN1:
Showing top 20/215 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ATXN1 | KIAA0586 | 0.714193 | 3 | 0 | 3 |
| ATXN1 | PDE8A | 0.713953 | 3 | 0 | 3 |
| ATXN1 | PLIN2 | 0.710113 | 3 | 0 | 3 |
| ATXN1 | CUL1 | 0.672476 | 3 | 0 | 3 |
| ATXN1 | SAE1 | 0.662934 | 3 | 0 | 3 |
| ATXN1 | SENP6 | 0.659791 | 3 | 0 | 3 |
| ATXN1 | REEP5 | 0.654778 | 5 | 0 | 5 |
| ATXN1 | ALKBH1 | 0.653251 | 3 | 0 | 3 |
| ATXN1 | MAPK1IP1L | 0.644749 | 3 | 0 | 3 |
| ATXN1 | IRAK3 | 0.643208 | 4 | 0 | 3 |
| ATXN1 | BOD1 | 0.63084 | 4 | 0 | 3 |
| ATXN1 | SMAD2 | 0.625049 | 4 | 0 | 3 |
| ATXN1 | COQ9 | 0.624437 | 3 | 0 | 3 |
| ATXN1 | RCBTB1 | 0.622575 | 3 | 0 | 3 |
| ATXN1 | SCAMP1 | 0.621992 | 6 | 0 | 5 |
| ATXN1 | COPS4 | 0.616661 | 4 | 0 | 3 |
| ATXN1 | ISY1 | 0.616615 | 3 | 0 | 3 |
| ATXN1 | BRAP | 0.616131 | 3 | 0 | 3 |
| ATXN1 | NFKB1 | 0.610386 | 3 | 0 | 3 |
| ATXN1 | KCTD10 | 0.610278 | 4 | 0 | 3 |
For details and further investigation, click here
