| Full name: aurora kinase C | Alias Symbol: AurC|ARK3 | ||
| Type: protein-coding gene | Cytoband: 19q13.43 | ||
| Entrez ID: 6795 | HGNC ID: HGNC:11391 | Ensembl Gene: ENSG00000105146 | OMIM ID: 603495 |
| Drug and gene relationship at DGIdb | |||
Expression of AURKC:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AURKC | 6795 | 211107_s_at | -0.1902 | 0.6983 | |
| GSE20347 | AURKC | 6795 | 211107_s_at | -0.0713 | 0.5803 | |
| GSE23400 | AURKC | 6795 | 211107_s_at | -0.1255 | 0.0048 | |
| GSE26886 | AURKC | 6795 | 211107_s_at | -0.4401 | 0.0017 | |
| GSE29001 | AURKC | 6795 | 211107_s_at | -0.3626 | 0.0129 | |
| GSE38129 | AURKC | 6795 | 211107_s_at | -0.0837 | 0.4602 | |
| GSE45670 | AURKC | 6795 | 211107_s_at | -0.1994 | 0.1310 | |
| GSE53622 | AURKC | 6795 | 2586 | -0.2526 | 0.0009 | |
| GSE53624 | AURKC | 6795 | 2586 | -0.1884 | 0.0037 | |
| GSE63941 | AURKC | 6795 | 211107_s_at | 0.1730 | 0.4872 | |
| GSE77861 | AURKC | 6795 | 211107_s_at | -0.2375 | 0.0960 | |
| GSE97050 | AURKC | 6795 | A_23_P50232 | -0.0228 | 0.9294 | |
| SRP064894 | AURKC | 6795 | RNAseq | 0.1364 | 0.6387 | |
| SRP133303 | AURKC | 6795 | RNAseq | 0.1676 | 0.6357 | |
| SRP159526 | AURKC | 6795 | RNAseq | -0.8077 | 0.1951 | |
| SRP219564 | AURKC | 6795 | RNAseq | 0.1001 | 0.7825 | |
| TCGA | AURKC | 6795 | RNAseq | -0.1413 | 0.6369 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by AURKC expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AURKC:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AURKC | 6795 | 2 | 4 | 24 | |
| GSE20123 | AURKC | 6795 | 2 | 3 | 25 | |
| GSE43470 | AURKC | 6795 | 2 | 9 | 32 | |
| GSE46452 | AURKC | 6795 | 45 | 1 | 13 | |
| GSE47630 | AURKC | 6795 | 8 | 6 | 26 | |
| GSE54993 | AURKC | 6795 | 18 | 4 | 48 | |
| GSE54994 | AURKC | 6795 | 5 | 12 | 36 | |
| GSE60625 | AURKC | 6795 | 9 | 0 | 2 | |
| GSE74703 | AURKC | 6795 | 2 | 6 | 28 | |
| GSE74704 | AURKC | 6795 | 2 | 1 | 17 | |
| TCGA | AURKC | 6795 | 21 | 15 | 60 |
Total number of gains: 116; Total number of losses: 61; Total Number of normals: 311.
Somatic mutations of AURKC:
Generating mutation plots.
Highly correlated genes for AURKC:
Showing top 20/410 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AURKC | G6PC2 | 0.672085 | 4 | 0 | 4 |
| AURKC | HABP2 | 0.650476 | 3 | 0 | 3 |
| AURKC | GPR4 | 0.647003 | 4 | 0 | 4 |
| AURKC | SH3TC2 | 0.642791 | 4 | 0 | 3 |
| AURKC | BFSP2 | 0.640865 | 3 | 0 | 3 |
| AURKC | PIK3R5 | 0.635521 | 4 | 0 | 4 |
| AURKC | P2RX6 | 0.629752 | 5 | 0 | 4 |
| AURKC | DPEP1 | 0.625887 | 4 | 0 | 4 |
| AURKC | SLC8A2 | 0.625264 | 4 | 0 | 3 |
| AURKC | KIR2DS3 | 0.622303 | 4 | 0 | 4 |
| AURKC | MAPK13 | 0.620747 | 3 | 0 | 3 |
| AURKC | GDPD5 | 0.619362 | 4 | 0 | 4 |
| AURKC | ODF1 | 0.613682 | 4 | 0 | 4 |
| AURKC | A1CF | 0.613029 | 8 | 0 | 6 |
| AURKC | SMCP | 0.610978 | 6 | 0 | 5 |
| AURKC | THEG | 0.610385 | 6 | 0 | 5 |
| AURKC | CHAD | 0.60925 | 4 | 0 | 4 |
| AURKC | C11orf16 | 0.607226 | 4 | 0 | 4 |
| AURKC | XDH | 0.602834 | 4 | 0 | 3 |
| AURKC | SLC28A2 | 0.602411 | 6 | 0 | 4 |
For details and further investigation, click here
