| Full name: solute carrier family 8 member A2 | Alias Symbol: NCX2|KIAA1087 | ||
| Type: protein-coding gene | Cytoband: 19q13.32 | ||
| Entrez ID: 6543 | HGNC ID: HGNC:11069 | Ensembl Gene: ENSG00000118160 | OMIM ID: 601901 |
| Drug and gene relationship at DGIdb | |||
SLC8A2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04020 | Calcium signaling pathway | |
| hsa04022 | cGMP-PKG signaling pathway |
Expression of SLC8A2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SLC8A2 | 6543 | 215267_s_at | -0.2075 | 0.5975 | |
| GSE20347 | SLC8A2 | 6543 | 215267_s_at | -0.1385 | 0.1156 | |
| GSE23400 | SLC8A2 | 6543 | 215267_s_at | -0.1718 | 0.0000 | |
| GSE26886 | SLC8A2 | 6543 | 215267_s_at | 0.1076 | 0.5155 | |
| GSE29001 | SLC8A2 | 6543 | 215267_s_at | -0.2403 | 0.1386 | |
| GSE38129 | SLC8A2 | 6543 | 215267_s_at | -0.2912 | 0.0024 | |
| GSE45670 | SLC8A2 | 6543 | 215267_s_at | -0.1604 | 0.1910 | |
| GSE53622 | SLC8A2 | 6543 | 30202 | -1.3632 | 0.0000 | |
| GSE53624 | SLC8A2 | 6543 | 30202 | -1.1776 | 0.0000 | |
| GSE63941 | SLC8A2 | 6543 | 215267_s_at | 0.1143 | 0.5362 | |
| GSE77861 | SLC8A2 | 6543 | 215267_s_at | -0.0360 | 0.8888 | |
| SRP133303 | SLC8A2 | 6543 | RNAseq | -0.8266 | 0.1748 | |
| SRP159526 | SLC8A2 | 6543 | RNAseq | -0.5782 | 0.3128 | |
| SRP219564 | SLC8A2 | 6543 | RNAseq | -1.7656 | 0.0113 | |
| TCGA | SLC8A2 | 6543 | RNAseq | -1.0275 | 0.0116 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by SLC8A2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SLC8A2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SLC8A2 | 6543 | 4 | 4 | 22 | |
| GSE20123 | SLC8A2 | 6543 | 4 | 3 | 23 | |
| GSE43470 | SLC8A2 | 6543 | 3 | 10 | 30 | |
| GSE46452 | SLC8A2 | 6543 | 45 | 1 | 13 | |
| GSE47630 | SLC8A2 | 6543 | 8 | 7 | 25 | |
| GSE54993 | SLC8A2 | 6543 | 17 | 4 | 49 | |
| GSE54994 | SLC8A2 | 6543 | 4 | 14 | 35 | |
| GSE60625 | SLC8A2 | 6543 | 9 | 0 | 2 | |
| GSE74703 | SLC8A2 | 6543 | 3 | 7 | 26 | |
| GSE74704 | SLC8A2 | 6543 | 4 | 1 | 15 | |
| TCGA | SLC8A2 | 6543 | 14 | 18 | 64 |
Total number of gains: 115; Total number of losses: 69; Total Number of normals: 304.
Somatic mutations of SLC8A2:
Generating mutation plots.
Highly correlated genes for SLC8A2:
Showing top 20/694 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SLC8A2 | BRINP2 | 0.692968 | 4 | 0 | 4 |
| SLC8A2 | MTAP | 0.658656 | 4 | 0 | 4 |
| SLC8A2 | C3orf36 | 0.655036 | 4 | 0 | 4 |
| SLC8A2 | UPK2 | 0.65233 | 4 | 0 | 4 |
| SLC8A2 | PIK3R5 | 0.650908 | 3 | 0 | 3 |
| SLC8A2 | TERT | 0.64731 | 3 | 0 | 3 |
| SLC8A2 | FOLH1 | 0.643571 | 3 | 0 | 3 |
| SLC8A2 | HAL | 0.642049 | 3 | 0 | 3 |
| SLC8A2 | DTNA | 0.641952 | 6 | 0 | 6 |
| SLC8A2 | BMP15 | 0.639599 | 4 | 0 | 3 |
| SLC8A2 | CDC14A | 0.639095 | 3 | 0 | 3 |
| SLC8A2 | GYPB | 0.639041 | 3 | 0 | 3 |
| SLC8A2 | OR1G1 | 0.638934 | 4 | 0 | 3 |
| SLC8A2 | GABRR2 | 0.637244 | 4 | 0 | 4 |
| SLC8A2 | INPP5A | 0.63692 | 3 | 0 | 3 |
| SLC8A2 | ZNF460 | 0.63681 | 3 | 0 | 3 |
| SLC8A2 | PHLDB1 | 0.634051 | 4 | 0 | 3 |
| SLC8A2 | KRT2 | 0.632959 | 5 | 0 | 5 |
| SLC8A2 | TREML2 | 0.629399 | 5 | 0 | 4 |
| SLC8A2 | CACNA1H | 0.629388 | 6 | 0 | 4 |
For details and further investigation, click here
