| Full name: SH3 domain and tetratricopeptide repeats 2 | Alias Symbol: KIAA1985|CMT4C | ||
| Type: protein-coding gene | Cytoband: 5q32 | ||
| Entrez ID: 79628 | HGNC ID: HGNC:29427 | Ensembl Gene: ENSG00000169247 | OMIM ID: 608206 |
| Drug and gene relationship at DGIdb | |||
Expression of SH3TC2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SH3TC2 | 79628 | 219710_at | -0.9668 | 0.1854 | |
| GSE20347 | SH3TC2 | 79628 | 219710_at | -0.3575 | 0.0017 | |
| GSE23400 | SH3TC2 | 79628 | 219710_at | -0.3693 | 0.0000 | |
| GSE26886 | SH3TC2 | 79628 | 219710_at | -1.0407 | 0.0008 | |
| GSE29001 | SH3TC2 | 79628 | 219710_at | -0.7798 | 0.0032 | |
| GSE38129 | SH3TC2 | 79628 | 219710_at | -0.4698 | 0.0004 | |
| GSE45670 | SH3TC2 | 79628 | 219710_at | -0.0700 | 0.8154 | |
| GSE53622 | SH3TC2 | 79628 | 25436 | -1.4024 | 0.0000 | |
| GSE53624 | SH3TC2 | 79628 | 25436 | -1.5213 | 0.0000 | |
| GSE63941 | SH3TC2 | 79628 | 219710_at | 0.3891 | 0.5345 | |
| GSE77861 | SH3TC2 | 79628 | 219710_at | -0.2429 | 0.1500 | |
| SRP008496 | SH3TC2 | 79628 | RNAseq | -2.9464 | 0.0000 | |
| SRP064894 | SH3TC2 | 79628 | RNAseq | -1.9829 | 0.0000 | |
| SRP133303 | SH3TC2 | 79628 | RNAseq | -1.0612 | 0.0000 | |
| SRP159526 | SH3TC2 | 79628 | RNAseq | -1.2856 | 0.0035 | |
| SRP193095 | SH3TC2 | 79628 | RNAseq | -1.1136 | 0.0000 | |
| SRP219564 | SH3TC2 | 79628 | RNAseq | -0.7810 | 0.1848 | |
| TCGA | SH3TC2 | 79628 | RNAseq | 0.3654 | 0.1687 |
Upregulated datasets: 0; Downregulated datasets: 8.
Survival by SH3TC2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SH3TC2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SH3TC2 | 79628 | 1 | 12 | 17 | |
| GSE20123 | SH3TC2 | 79628 | 1 | 12 | 17 | |
| GSE43470 | SH3TC2 | 79628 | 2 | 9 | 32 | |
| GSE46452 | SH3TC2 | 79628 | 0 | 27 | 32 | |
| GSE47630 | SH3TC2 | 79628 | 0 | 20 | 20 | |
| GSE54993 | SH3TC2 | 79628 | 9 | 1 | 60 | |
| GSE54994 | SH3TC2 | 79628 | 2 | 15 | 36 | |
| GSE60625 | SH3TC2 | 79628 | 0 | 0 | 11 | |
| GSE74703 | SH3TC2 | 79628 | 2 | 7 | 27 | |
| GSE74704 | SH3TC2 | 79628 | 1 | 7 | 12 | |
| TCGA | SH3TC2 | 79628 | 5 | 38 | 53 |
Total number of gains: 23; Total number of losses: 148; Total Number of normals: 317.
Somatic mutations of SH3TC2:
Generating mutation plots.
Highly correlated genes for SH3TC2:
Showing top 20/857 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SH3TC2 | TMEM184A | 0.694903 | 3 | 0 | 3 |
| SH3TC2 | GYS2 | 0.684494 | 10 | 0 | 10 |
| SH3TC2 | ECM1 | 0.677539 | 9 | 0 | 9 |
| SH3TC2 | WNK4 | 0.676172 | 4 | 0 | 3 |
| SH3TC2 | KRT78 | 0.67616 | 5 | 0 | 5 |
| SH3TC2 | FNDC4 | 0.673214 | 10 | 0 | 9 |
| SH3TC2 | RBPMS-AS1 | 0.67197 | 3 | 0 | 3 |
| SH3TC2 | ZNF365 | 0.670783 | 10 | 0 | 10 |
| SH3TC2 | PRSS27 | 0.667464 | 6 | 0 | 6 |
| SH3TC2 | MXD1 | 0.666175 | 10 | 0 | 10 |
| SH3TC2 | PADI1 | 0.663284 | 9 | 0 | 8 |
| SH3TC2 | SPINK7 | 0.662266 | 5 | 0 | 5 |
| SH3TC2 | A2ML1 | 0.662186 | 5 | 0 | 5 |
| SH3TC2 | LINC00551 | 0.659823 | 5 | 0 | 4 |
| SH3TC2 | ALS2CL | 0.659724 | 10 | 0 | 9 |
| SH3TC2 | SULT2B1 | 0.659261 | 7 | 0 | 7 |
| SH3TC2 | ESPL1 | 0.658955 | 10 | 0 | 10 |
| SH3TC2 | TMPRSS11B | 0.65693 | 5 | 0 | 5 |
| SH3TC2 | CRISP3 | 0.655362 | 9 | 0 | 9 |
| SH3TC2 | ATP6V1C2 | 0.655295 | 4 | 0 | 3 |
For details and further investigation, click here
