| Full name: protein phosphatase 1 regulatory inhibitor subunit 2 | Alias Symbol: IPP2|PPP1R2A | ||
| Type: protein-coding gene | Cytoband: 3q29 | ||
| Entrez ID: 5504 | HGNC ID: HGNC:9288 | Ensembl Gene: ENSG00000184203 | OMIM ID: 601792 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of PPP1R2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PPP1R2 | 5504 | 202166_s_at | -0.1334 | 0.7296 | |
| GSE20347 | PPP1R2 | 5504 | 202166_s_at | -0.5483 | 0.0446 | |
| GSE23400 | PPP1R2 | 5504 | 202166_s_at | -0.3593 | 0.0011 | |
| GSE26886 | PPP1R2 | 5504 | 202165_at | -0.9245 | 0.0085 | |
| GSE29001 | PPP1R2 | 5504 | 202166_s_at | -0.4356 | 0.4474 | |
| GSE38129 | PPP1R2 | 5504 | 202166_s_at | -0.1501 | 0.5565 | |
| GSE45670 | PPP1R2 | 5504 | 202166_s_at | -0.0878 | 0.7461 | |
| GSE53622 | PPP1R2 | 5504 | 97941 | -0.1653 | 0.0938 | |
| GSE53624 | PPP1R2 | 5504 | 97941 | -0.2227 | 0.0386 | |
| GSE63941 | PPP1R2 | 5504 | 202166_s_at | 0.9664 | 0.0197 | |
| GSE77861 | PPP1R2 | 5504 | 202166_s_at | -0.3439 | 0.3698 | |
| GSE97050 | PPP1R2 | 5504 | A_33_P3306964 | 0.0964 | 0.7580 | |
| SRP007169 | PPP1R2 | 5504 | RNAseq | -1.1562 | 0.0001 | |
| SRP008496 | PPP1R2 | 5504 | RNAseq | -0.6537 | 0.0063 | |
| SRP064894 | PPP1R2 | 5504 | RNAseq | -0.2338 | 0.1725 | |
| SRP133303 | PPP1R2 | 5504 | RNAseq | 0.3591 | 0.0241 | |
| SRP159526 | PPP1R2 | 5504 | RNAseq | 0.1639 | 0.6413 | |
| SRP193095 | PPP1R2 | 5504 | RNAseq | -0.2486 | 0.0678 | |
| SRP219564 | PPP1R2 | 5504 | RNAseq | -0.3160 | 0.3670 | |
| TCGA | PPP1R2 | 5504 | RNAseq | 0.0940 | 0.0454 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by PPP1R2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PPP1R2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PPP1R2 | 5504 | 22 | 0 | 8 | |
| GSE20123 | PPP1R2 | 5504 | 22 | 0 | 8 | |
| GSE43470 | PPP1R2 | 5504 | 22 | 0 | 21 | |
| GSE46452 | PPP1R2 | 5504 | 19 | 1 | 39 | |
| GSE47630 | PPP1R2 | 5504 | 27 | 2 | 11 | |
| GSE54993 | PPP1R2 | 5504 | 1 | 22 | 47 | |
| GSE54994 | PPP1R2 | 5504 | 41 | 0 | 12 | |
| GSE60625 | PPP1R2 | 5504 | 0 | 6 | 5 | |
| GSE74703 | PPP1R2 | 5504 | 19 | 0 | 17 | |
| GSE74704 | PPP1R2 | 5504 | 14 | 0 | 6 | |
| TCGA | PPP1R2 | 5504 | 77 | 0 | 19 |
Total number of gains: 264; Total number of losses: 31; Total Number of normals: 193.
Somatic mutations of PPP1R2:
Generating mutation plots.
Highly correlated genes for PPP1R2:
Showing top 20/617 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PPP1R2 | USP38 | 0.792668 | 3 | 0 | 3 |
| PPP1R2 | STK38 | 0.775955 | 3 | 0 | 3 |
| PPP1R2 | IDI1 | 0.771663 | 3 | 0 | 3 |
| PPP1R2 | RAP2C | 0.762301 | 3 | 0 | 3 |
| PPP1R2 | FBXO8 | 0.756581 | 3 | 0 | 3 |
| PPP1R2 | SNX14 | 0.743872 | 3 | 0 | 3 |
| PPP1R2 | DPH3 | 0.734774 | 4 | 0 | 4 |
| PPP1R2 | ZNF878 | 0.731867 | 3 | 0 | 3 |
| PPP1R2 | ABLIM2 | 0.730238 | 3 | 0 | 3 |
| PPP1R2 | AZI2 | 0.73006 | 4 | 0 | 3 |
| PPP1R2 | MLLT10 | 0.727547 | 3 | 0 | 3 |
| PPP1R2 | EXOC6B | 0.72 | 3 | 0 | 3 |
| PPP1R2 | RNASEL | 0.71021 | 4 | 0 | 4 |
| PPP1R2 | SNX4 | 0.707212 | 4 | 0 | 3 |
| PPP1R2 | CRBN | 0.705715 | 4 | 0 | 4 |
| PPP1R2 | ARFGEF2 | 0.704655 | 5 | 0 | 4 |
| PPP1R2 | RAB18 | 0.7037 | 4 | 0 | 4 |
| PPP1R2 | ATG3 | 0.700825 | 4 | 0 | 3 |
| PPP1R2 | DNAJC15 | 0.697202 | 3 | 0 | 3 |
| PPP1R2 | NAA15 | 0.69466 | 3 | 0 | 3 |
For details and further investigation, click here
