| Full name: beta-secretase 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 11q23.3 | ||
| Entrez ID: 23621 | HGNC ID: HGNC:933 | Ensembl Gene: ENSG00000186318 | OMIM ID: 604252 |
| Drug and gene relationship at DGIdb | |||
Expression of BACE1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BACE1 | 23621 | 222462_s_at | -0.2999 | 0.6954 | |
| GSE20347 | BACE1 | 23621 | 217904_s_at | -0.1757 | 0.3597 | |
| GSE23400 | BACE1 | 23621 | 217904_s_at | 0.0425 | 0.4909 | |
| GSE26886 | BACE1 | 23621 | 222462_s_at | -0.1358 | 0.4934 | |
| GSE29001 | BACE1 | 23621 | 217904_s_at | -0.4423 | 0.0472 | |
| GSE38129 | BACE1 | 23621 | 217904_s_at | -0.2006 | 0.1879 | |
| GSE45670 | BACE1 | 23621 | 222462_s_at | 0.0645 | 0.7744 | |
| GSE53622 | BACE1 | 23621 | 34768 | 0.0947 | 0.3256 | |
| GSE53624 | BACE1 | 23621 | 72896 | 0.1956 | 0.0067 | |
| GSE63941 | BACE1 | 23621 | 222462_s_at | -1.8411 | 0.0063 | |
| GSE77861 | BACE1 | 23621 | 222462_s_at | -0.0735 | 0.6405 | |
| GSE97050 | BACE1 | 23621 | A_23_P52806 | -0.3179 | 0.3165 | |
| SRP007169 | BACE1 | 23621 | RNAseq | 0.0492 | 0.8979 | |
| SRP008496 | BACE1 | 23621 | RNAseq | 0.4762 | 0.0883 | |
| SRP064894 | BACE1 | 23621 | RNAseq | 0.3688 | 0.0725 | |
| SRP133303 | BACE1 | 23621 | RNAseq | 0.0517 | 0.7290 | |
| SRP159526 | BACE1 | 23621 | RNAseq | -0.0774 | 0.7792 | |
| SRP193095 | BACE1 | 23621 | RNAseq | -0.0291 | 0.8405 | |
| SRP219564 | BACE1 | 23621 | RNAseq | -0.0154 | 0.9548 | |
| TCGA | BACE1 | 23621 | RNAseq | -0.0769 | 0.1605 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by BACE1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of BACE1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BACE1 | 23621 | 1 | 13 | 16 | |
| GSE20123 | BACE1 | 23621 | 1 | 13 | 16 | |
| GSE43470 | BACE1 | 23621 | 2 | 8 | 33 | |
| GSE46452 | BACE1 | 23621 | 3 | 26 | 30 | |
| GSE47630 | BACE1 | 23621 | 2 | 19 | 19 | |
| GSE54993 | BACE1 | 23621 | 10 | 0 | 60 | |
| GSE54994 | BACE1 | 23621 | 5 | 19 | 29 | |
| GSE60625 | BACE1 | 23621 | 0 | 3 | 8 | |
| GSE74703 | BACE1 | 23621 | 1 | 5 | 30 | |
| GSE74704 | BACE1 | 23621 | 0 | 9 | 11 | |
| TCGA | BACE1 | 23621 | 5 | 50 | 41 |
Total number of gains: 30; Total number of losses: 165; Total Number of normals: 293.
Somatic mutations of BACE1:
Generating mutation plots.
Highly correlated genes for BACE1:
Showing top 20/35 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BACE1 | TCTA | 0.640416 | 4 | 0 | 3 |
| BACE1 | ZNF415 | 0.612425 | 4 | 0 | 3 |
| BACE1 | MAPKBP1 | 0.608576 | 3 | 0 | 3 |
| BACE1 | CYP27A1 | 0.582038 | 3 | 0 | 3 |
| BACE1 | MOCS1 | 0.573646 | 5 | 0 | 3 |
| BACE1 | ZNF781 | 0.565419 | 3 | 0 | 3 |
| BACE1 | CYTL1 | 0.561734 | 4 | 0 | 3 |
| BACE1 | RUNDC3B | 0.552838 | 3 | 0 | 3 |
| BACE1 | NOL3 | 0.549233 | 5 | 0 | 3 |
| BACE1 | HSPB2 | 0.548593 | 7 | 0 | 4 |
| BACE1 | AK5 | 0.539961 | 6 | 0 | 4 |
| BACE1 | PTGER3 | 0.534604 | 4 | 0 | 3 |
| BACE1 | FAT4 | 0.534441 | 5 | 0 | 3 |
| BACE1 | NPDC1 | 0.532317 | 4 | 0 | 3 |
| BACE1 | ZC4H2 | 0.530323 | 6 | 0 | 3 |
| BACE1 | PLEKHA4 | 0.529492 | 4 | 0 | 3 |
| BACE1 | NRXN3 | 0.527592 | 4 | 0 | 3 |
| BACE1 | VGLL3 | 0.526053 | 4 | 0 | 4 |
| BACE1 | ACAT1 | 0.524246 | 4 | 0 | 3 |
| BACE1 | ZSCAN18 | 0.521331 | 5 | 0 | 3 |
For details and further investigation, click here
