| Full name: adenylate kinase 5 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1p31.1 | ||
| Entrez ID: 26289 | HGNC ID: HGNC:365 | Ensembl Gene: ENSG00000154027 | OMIM ID: 608009 |
| Drug and gene relationship at DGIdb | |||
Expression of AK5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AK5 | 26289 | 222862_s_at | 0.0359 | 0.9655 | |
| GSE20347 | AK5 | 26289 | 219308_s_at | 0.0196 | 0.7748 | |
| GSE23400 | AK5 | 26289 | 219308_s_at | -0.1053 | 0.0038 | |
| GSE26886 | AK5 | 26289 | 222862_s_at | 0.2353 | 0.0518 | |
| GSE29001 | AK5 | 26289 | 219308_s_at | -0.0612 | 0.7253 | |
| GSE38129 | AK5 | 26289 | 219308_s_at | -0.3205 | 0.0117 | |
| GSE45670 | AK5 | 26289 | 222862_s_at | -0.2634 | 0.0169 | |
| GSE53622 | AK5 | 26289 | 40763 | 0.1334 | 0.4529 | |
| GSE53624 | AK5 | 26289 | 40763 | 0.4909 | 0.0000 | |
| GSE63941 | AK5 | 26289 | 222862_s_at | -3.7125 | 0.0010 | |
| GSE77861 | AK5 | 26289 | 222862_s_at | -0.0827 | 0.4074 | |
| GSE97050 | AK5 | 26289 | A_33_P3307253 | -0.1326 | 0.6676 | |
| SRP133303 | AK5 | 26289 | RNAseq | 0.7082 | 0.0621 | |
| SRP159526 | AK5 | 26289 | RNAseq | -0.5925 | 0.2325 | |
| SRP219564 | AK5 | 26289 | RNAseq | 0.9092 | 0.2680 | |
| TCGA | AK5 | 26289 | RNAseq | -0.1704 | 0.6390 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by AK5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AK5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AK5 | 26289 | 0 | 7 | 23 | |
| GSE20123 | AK5 | 26289 | 0 | 7 | 23 | |
| GSE43470 | AK5 | 26289 | 3 | 3 | 37 | |
| GSE46452 | AK5 | 26289 | 0 | 1 | 58 | |
| GSE47630 | AK5 | 26289 | 8 | 6 | 26 | |
| GSE54993 | AK5 | 26289 | 0 | 0 | 70 | |
| GSE54994 | AK5 | 26289 | 6 | 3 | 44 | |
| GSE60625 | AK5 | 26289 | 0 | 0 | 11 | |
| GSE74703 | AK5 | 26289 | 2 | 3 | 31 | |
| GSE74704 | AK5 | 26289 | 0 | 4 | 16 | |
| TCGA | AK5 | 26289 | 8 | 24 | 64 |
Total number of gains: 27; Total number of losses: 58; Total Number of normals: 403.
Somatic mutations of AK5:
Generating mutation plots.
Highly correlated genes for AK5:
Showing top 20/409 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AK5 | FAP | 0.754703 | 3 | 0 | 3 |
| AK5 | PCDH9 | 0.734345 | 5 | 0 | 5 |
| AK5 | SRPK3 | 0.732847 | 3 | 0 | 3 |
| AK5 | TBX2 | 0.692201 | 4 | 0 | 3 |
| AK5 | TBX4 | 0.691457 | 3 | 0 | 3 |
| AK5 | SHC3 | 0.684972 | 4 | 0 | 4 |
| AK5 | ZMAT4 | 0.674901 | 3 | 0 | 3 |
| AK5 | CNTN3 | 0.674318 | 4 | 0 | 3 |
| AK5 | ZNF221 | 0.666015 | 4 | 0 | 4 |
| AK5 | SPTA1 | 0.664538 | 4 | 0 | 4 |
| AK5 | LRRC2 | 0.662491 | 5 | 0 | 5 |
| AK5 | SHISA3 | 0.661027 | 4 | 0 | 3 |
| AK5 | LAMA4 | 0.660466 | 8 | 0 | 8 |
| AK5 | LMAN1L | 0.6588 | 4 | 0 | 4 |
| AK5 | MT1G | 0.657465 | 4 | 0 | 3 |
| AK5 | LALBA | 0.655565 | 3 | 0 | 3 |
| AK5 | DNM3OS | 0.654117 | 4 | 0 | 4 |
| AK5 | TSHB | 0.653984 | 5 | 0 | 5 |
| AK5 | MRGPRF | 0.653626 | 5 | 0 | 5 |
| AK5 | DMC1 | 0.652887 | 3 | 0 | 3 |
For details and further investigation, click here
