BCAR1

 

Full name: BCAR1 scaffold protein, Cas family member Alias Symbol: P130Cas|Crkas|CAS|CASS1
Type: protein-coding gene Cytoband: 16q23.1
Entrez ID: 9564 HGNC ID: HGNC:971 Ensembl Gene: ENSG00000050820 OMIM ID: 602941
Drug and gene relationship at DGIdb
Screen Evidence:

 

BCAR1 involved pathways:

KEGG pathway Description View
hsa04015Rap1 signaling pathway
hsa04062Chemokine signaling pathway
hsa04510Focal adhesion
hsa04670Leukocyte transendothelial migration
hsa04810Regulation of actin cytoskeleton
hsa05100Bacterial invasion of epithelial cells

 

Expression of BCAR1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 BCAR1 9564 223116_at 0.5837 0.0535
GSE26886 BCAR1 9564 223116_at 0.9686 0.0000
GSE45670 BCAR1 9564 223116_at 0.3919 0.0006
GSE53622 BCAR1 9564 9565 0.5276 0.0000
GSE53624 BCAR1 9564 9565 0.6754 0.0000
GSE63941 BCAR1 9564 223116_at -0.2318 0.5679
GSE77861 BCAR1 9564 223116_at 0.3093 0.0313
GSE97050 BCAR1 9564 A_33_P3229272 0.7506 0.1278
SRP007169 BCAR1 9564 RNAseq 0.7844 0.0732
SRP008496 BCAR1 9564 RNAseq -0.0408 0.8968
SRP064894 BCAR1 9564 RNAseq 0.6889 0.0024
SRP133303 BCAR1 9564 RNAseq 1.0164 0.0000
SRP159526 BCAR1 9564 RNAseq 0.7164 0.0037
SRP193095 BCAR1 9564 RNAseq 0.5466 0.0285
SRP219564 BCAR1 9564 RNAseq 0.4399 0.1067
TCGA BCAR1 9564 RNAseq -0.1090 0.0327

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by BCAR1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of BCAR1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 BCAR1 9564 6 1 23
GSE20123 BCAR1 9564 6 1 23
GSE43470 BCAR1 9564 2 8 33
GSE46452 BCAR1 9564 37 2 20
GSE47630 BCAR1 9564 11 8 21
GSE54993 BCAR1 9564 2 4 64
GSE54994 BCAR1 9564 8 10 35
GSE60625 BCAR1 9564 4 0 7
GSE74703 BCAR1 9564 2 5 29
GSE74704 BCAR1 9564 3 0 17
TCGA BCAR1 9564 25 15 56

Total number of gains: 106; Total number of losses: 54; Total Number of normals: 328.  

 

Somatic mutations of BCAR1:

 

Generating mutation plots.

 

Highly correlated genes for BCAR1:

 

Showing top 20/1402 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
BCAR1USB10.763067706
BCAR1CCDC860.751395505
BCAR1CHTF180.748878505
BCAR1ADCY30.743638404
BCAR1SKP20.743374303
BCAR1MYBL20.731466706
BCAR1KIF150.730447303
BCAR1NEBL-AS10.723361303
BCAR1TUBA1B0.718319404
BCAR1DNAJC90.714932303
BCAR1PHLDA20.713259404
BCAR1ZNF5930.711402404
BCAR1TRAF70.711299505
BCAR1TMEM184B0.708152808
BCAR1TBX10.706575505
BCAR1TUBA1C0.705404403
BCAR1FANCD20.704766303
BCAR1TMEM132A0.703952605
BCAR1MMP10.702471706
BCAR1NCAPH0.698444404

For details and further investigation, click here