| Full name: U6 snRNA biogenesis phosphodiesterase 1 | Alias Symbol: FLJ13154|HVSL1|Mpn1 | ||
| Type: protein-coding gene | Cytoband: 16q21 | ||
| Entrez ID: 79650 | HGNC ID: HGNC:25792 | Ensembl Gene: ENSG00000103005 | OMIM ID: 613276 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of USB1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | USB1 | 79650 | 218060_s_at | 0.7820 | 0.0262 | |
| GSE20347 | USB1 | 79650 | 218060_s_at | 0.8346 | 0.0000 | |
| GSE23400 | USB1 | 79650 | 218060_s_at | 0.3852 | 0.0000 | |
| GSE26886 | USB1 | 79650 | 218060_s_at | 0.8417 | 0.0000 | |
| GSE29001 | USB1 | 79650 | 218060_s_at | 0.5496 | 0.0053 | |
| GSE38129 | USB1 | 79650 | 218060_s_at | 0.7429 | 0.0000 | |
| GSE45670 | USB1 | 79650 | 218060_s_at | 0.7885 | 0.0000 | |
| GSE53622 | USB1 | 79650 | 2845 | 0.9789 | 0.0000 | |
| GSE53624 | USB1 | 79650 | 2845 | 1.2320 | 0.0000 | |
| GSE63941 | USB1 | 79650 | 218060_s_at | -0.5400 | 0.0648 | |
| GSE77861 | USB1 | 79650 | 218060_s_at | 0.4244 | 0.0036 | |
| SRP007169 | USB1 | 79650 | RNAseq | 1.4705 | 0.0003 | |
| SRP008496 | USB1 | 79650 | RNAseq | 1.6609 | 0.0000 | |
| SRP064894 | USB1 | 79650 | RNAseq | 1.3434 | 0.0000 | |
| SRP133303 | USB1 | 79650 | RNAseq | 1.4607 | 0.0000 | |
| SRP159526 | USB1 | 79650 | RNAseq | 1.0349 | 0.0000 | |
| SRP193095 | USB1 | 79650 | RNAseq | 1.2527 | 0.0000 | |
| SRP219564 | USB1 | 79650 | RNAseq | 0.5213 | 0.2692 |
Upregulated datasets: 7; Downregulated datasets: 0.
Survival by USB1 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of USB1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | USB1 | 79650 | 6 | 0 | 24 | |
| GSE20123 | USB1 | 79650 | 6 | 1 | 23 | |
| GSE43470 | USB1 | 79650 | 2 | 7 | 34 | |
| GSE46452 | USB1 | 79650 | 38 | 1 | 20 | |
| GSE47630 | USB1 | 79650 | 10 | 8 | 22 | |
| GSE54993 | USB1 | 79650 | 2 | 4 | 64 | |
| GSE54994 | USB1 | 79650 | 6 | 10 | 37 | |
| GSE60625 | USB1 | 79650 | 4 | 0 | 7 | |
| GSE74703 | USB1 | 79650 | 2 | 5 | 29 | |
| GSE74704 | USB1 | 79650 | 5 | 0 | 15 | |
| TCGA | USB1 | 79650 | 26 | 11 | 59 |
Total number of gains: 107; Total number of losses: 47; Total Number of normals: 334.
Somatic mutations of USB1:
Generating mutation plots.
Highly correlated genes for USB1:
Showing top 20/1613 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| USB1 | HOMER3 | 0.796054 | 11 | 0 | 11 |
| USB1 | TMEM184B | 0.782914 | 10 | 0 | 10 |
| USB1 | LAMC2 | 0.780531 | 10 | 0 | 10 |
| USB1 | TTYH3 | 0.780458 | 6 | 0 | 6 |
| USB1 | FHOD1 | 0.77658 | 11 | 0 | 11 |
| USB1 | FSCN1 | 0.769091 | 10 | 0 | 10 |
| USB1 | EME1 | 0.766666 | 4 | 0 | 4 |
| USB1 | BCAR1 | 0.763067 | 7 | 0 | 6 |
| USB1 | TMEM132A | 0.760658 | 8 | 0 | 8 |
| USB1 | C16orf74 | 0.757888 | 6 | 0 | 6 |
| USB1 | XPR1 | 0.754358 | 6 | 0 | 6 |
| USB1 | WDR54 | 0.752288 | 6 | 0 | 6 |
| USB1 | MMP1 | 0.75137 | 11 | 0 | 11 |
| USB1 | STC2 | 0.749861 | 9 | 0 | 8 |
| USB1 | COLGALT1 | 0.747146 | 11 | 0 | 11 |
| USB1 | TGFBI | 0.746041 | 11 | 0 | 11 |
| USB1 | GPRIN1 | 0.743939 | 5 | 0 | 5 |
| USB1 | MYBL2 | 0.7439 | 10 | 0 | 10 |
| USB1 | FBLIM1 | 0.741561 | 6 | 0 | 6 |
| USB1 | PLAU | 0.741528 | 11 | 0 | 10 |
For details and further investigation, click here
