| Full name: pleckstrin homology like domain family A member 2 | Alias Symbol: IPL|BWR1C|HLDA2 | ||
| Type: protein-coding gene | Cytoband: 11p15.4 | ||
| Entrez ID: 7262 | HGNC ID: HGNC:12385 | Ensembl Gene: ENSG00000181649 | OMIM ID: 602131 |
| Drug and gene relationship at DGIdb | |||
Expression of PHLDA2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PHLDA2 | 7262 | 209803_s_at | -0.3894 | 0.7908 | |
| GSE20347 | PHLDA2 | 7262 | 209803_s_at | -0.4047 | 0.2499 | |
| GSE23400 | PHLDA2 | 7262 | 209803_s_at | 0.0492 | 0.8017 | |
| GSE26886 | PHLDA2 | 7262 | 209803_s_at | 0.4015 | 0.3718 | |
| GSE29001 | PHLDA2 | 7262 | 209803_s_at | -0.1161 | 0.7142 | |
| GSE38129 | PHLDA2 | 7262 | 209803_s_at | 0.4697 | 0.2197 | |
| GSE45670 | PHLDA2 | 7262 | 209803_s_at | 0.5410 | 0.0472 | |
| GSE53622 | PHLDA2 | 7262 | 30392 | 0.1152 | 0.6303 | |
| GSE53624 | PHLDA2 | 7262 | 30392 | 0.0641 | 0.6217 | |
| GSE63941 | PHLDA2 | 7262 | 209803_s_at | -0.1430 | 0.9154 | |
| GSE77861 | PHLDA2 | 7262 | 209803_s_at | 0.3083 | 0.3191 | |
| GSE97050 | PHLDA2 | 7262 | A_23_P47614 | 1.2382 | 0.1218 | |
| SRP007169 | PHLDA2 | 7262 | RNAseq | -0.4314 | 0.3741 | |
| SRP008496 | PHLDA2 | 7262 | RNAseq | -0.1845 | 0.6338 | |
| SRP064894 | PHLDA2 | 7262 | RNAseq | 0.2916 | 0.4459 | |
| SRP133303 | PHLDA2 | 7262 | RNAseq | 0.6199 | 0.0999 | |
| SRP159526 | PHLDA2 | 7262 | RNAseq | -0.6372 | 0.3178 | |
| SRP193095 | PHLDA2 | 7262 | RNAseq | -0.0477 | 0.8586 | |
| SRP219564 | PHLDA2 | 7262 | RNAseq | 0.0445 | 0.9460 | |
| TCGA | PHLDA2 | 7262 | RNAseq | 0.3234 | 0.0170 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PHLDA2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PHLDA2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PHLDA2 | 7262 | 1 | 11 | 18 | |
| GSE20123 | PHLDA2 | 7262 | 1 | 12 | 17 | |
| GSE43470 | PHLDA2 | 7262 | 1 | 10 | 32 | |
| GSE46452 | PHLDA2 | 7262 | 7 | 8 | 44 | |
| GSE47630 | PHLDA2 | 7262 | 4 | 12 | 24 | |
| GSE54993 | PHLDA2 | 7262 | 3 | 1 | 66 | |
| GSE54994 | PHLDA2 | 7262 | 1 | 12 | 40 | |
| GSE60625 | PHLDA2 | 7262 | 0 | 0 | 11 | |
| GSE74703 | PHLDA2 | 7262 | 1 | 8 | 27 | |
| GSE74704 | PHLDA2 | 7262 | 0 | 8 | 12 | |
| TCGA | PHLDA2 | 7262 | 8 | 39 | 49 |
Total number of gains: 27; Total number of losses: 121; Total Number of normals: 340.
Somatic mutations of PHLDA2:
Generating mutation plots.
Highly correlated genes for PHLDA2:
Showing top 20/328 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PHLDA2 | BCAR1 | 0.713259 | 4 | 0 | 4 |
| PHLDA2 | GJA1 | 0.712281 | 3 | 0 | 3 |
| PHLDA2 | AURKA | 0.702975 | 3 | 0 | 3 |
| PHLDA2 | STIP1 | 0.701503 | 3 | 0 | 3 |
| PHLDA2 | FAM111B | 0.696768 | 3 | 0 | 3 |
| PHLDA2 | CDSN | 0.684852 | 3 | 0 | 3 |
| PHLDA2 | MET | 0.684677 | 3 | 0 | 3 |
| PHLDA2 | TRAF7 | 0.673504 | 3 | 0 | 3 |
| PHLDA2 | DUSP7 | 0.672093 | 11 | 0 | 11 |
| PHLDA2 | AFAP1L2 | 0.671324 | 4 | 0 | 3 |
| PHLDA2 | RPF2 | 0.66997 | 3 | 0 | 3 |
| PHLDA2 | SP140L | 0.669044 | 3 | 0 | 3 |
| PHLDA2 | STAMBP | 0.664814 | 4 | 0 | 3 |
| PHLDA2 | SLC25A22 | 0.663881 | 4 | 0 | 4 |
| PHLDA2 | F2RL1 | 0.663637 | 8 | 0 | 7 |
| PHLDA2 | NOS1AP | 0.662583 | 3 | 0 | 3 |
| PHLDA2 | TNFRSF4 | 0.657848 | 3 | 0 | 3 |
| PHLDA2 | GJB3 | 0.650725 | 9 | 0 | 7 |
| PHLDA2 | TNFAIP3 | 0.648987 | 4 | 0 | 3 |
| PHLDA2 | CRX | 0.648674 | 3 | 0 | 3 |
For details and further investigation, click here
