| Full name: BCAR3 adaptor protein, NSP family member | Alias Symbol: NSP2|SH2D3B|AND-34 | ||
| Type: protein-coding gene | Cytoband: 1p22.1 | ||
| Entrez ID: 8412 | HGNC ID: HGNC:973 | Ensembl Gene: ENSG00000137936 | OMIM ID: 604704 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of BCAR3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BCAR3 | 8412 | 204032_at | 0.4815 | 0.4888 | |
| GSE20347 | BCAR3 | 8412 | 204032_at | -0.1363 | 0.5497 | |
| GSE23400 | BCAR3 | 8412 | 204032_at | -0.0406 | 0.4159 | |
| GSE26886 | BCAR3 | 8412 | 204032_at | 0.1802 | 0.7126 | |
| GSE29001 | BCAR3 | 8412 | 204032_at | -0.3240 | 0.4820 | |
| GSE38129 | BCAR3 | 8412 | 204032_at | -0.2010 | 0.2965 | |
| GSE45670 | BCAR3 | 8412 | 204032_at | -0.2231 | 0.5047 | |
| GSE53622 | BCAR3 | 8412 | 50692 | -0.4060 | 0.0085 | |
| GSE53624 | BCAR3 | 8412 | 50692 | -0.4715 | 0.0001 | |
| GSE63941 | BCAR3 | 8412 | 204032_at | -0.1829 | 0.8792 | |
| GSE77861 | BCAR3 | 8412 | 204032_at | -0.2992 | 0.2027 | |
| GSE97050 | BCAR3 | 8412 | A_23_P97394 | 0.0623 | 0.8725 | |
| SRP007169 | BCAR3 | 8412 | RNAseq | -1.8851 | 0.0001 | |
| SRP008496 | BCAR3 | 8412 | RNAseq | -1.7044 | 0.0000 | |
| SRP064894 | BCAR3 | 8412 | RNAseq | -0.4763 | 0.0332 | |
| SRP133303 | BCAR3 | 8412 | RNAseq | -0.1667 | 0.5261 | |
| SRP159526 | BCAR3 | 8412 | RNAseq | -0.7456 | 0.0551 | |
| SRP193095 | BCAR3 | 8412 | RNAseq | -0.1201 | 0.6972 | |
| SRP219564 | BCAR3 | 8412 | RNAseq | 0.7576 | 0.2686 | |
| TCGA | BCAR3 | 8412 | RNAseq | -0.0388 | 0.7267 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by BCAR3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of BCAR3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BCAR3 | 8412 | 0 | 8 | 22 | |
| GSE20123 | BCAR3 | 8412 | 0 | 8 | 22 | |
| GSE43470 | BCAR3 | 8412 | 2 | 6 | 35 | |
| GSE46452 | BCAR3 | 8412 | 1 | 1 | 57 | |
| GSE47630 | BCAR3 | 8412 | 8 | 5 | 27 | |
| GSE54993 | BCAR3 | 8412 | 0 | 1 | 69 | |
| GSE54994 | BCAR3 | 8412 | 6 | 3 | 44 | |
| GSE60625 | BCAR3 | 8412 | 0 | 0 | 11 | |
| GSE74703 | BCAR3 | 8412 | 1 | 5 | 30 | |
| GSE74704 | BCAR3 | 8412 | 0 | 5 | 15 | |
| TCGA | BCAR3 | 8412 | 6 | 24 | 66 |
Total number of gains: 24; Total number of losses: 66; Total Number of normals: 398.
Somatic mutations of BCAR3:
Generating mutation plots.
Highly correlated genes for BCAR3:
Showing top 20/151 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BCAR3 | PLEKHM2 | 0.808372 | 3 | 0 | 3 |
| BCAR3 | ZNF436 | 0.754482 | 3 | 0 | 3 |
| BCAR3 | B3GALNT1 | 0.726195 | 3 | 0 | 3 |
| BCAR3 | ATG4C | 0.718822 | 3 | 0 | 3 |
| BCAR3 | MCMBP | 0.711491 | 3 | 0 | 3 |
| BCAR3 | NUP188 | 0.709318 | 3 | 0 | 3 |
| BCAR3 | PHTF2 | 0.707104 | 3 | 0 | 3 |
| BCAR3 | PDIK1L | 0.698225 | 3 | 0 | 3 |
| BCAR3 | WSB2 | 0.692543 | 3 | 0 | 3 |
| BCAR3 | MRPS18B | 0.674285 | 3 | 0 | 3 |
| BCAR3 | ITPRIPL2 | 0.671968 | 3 | 0 | 3 |
| BCAR3 | RFNG | 0.664039 | 4 | 0 | 3 |
| BCAR3 | NEMF | 0.661618 | 3 | 0 | 3 |
| BCAR3 | MYSM1 | 0.659163 | 4 | 0 | 3 |
| BCAR3 | PPP2R1B | 0.658766 | 3 | 0 | 3 |
| BCAR3 | SH2D4A | 0.654006 | 3 | 0 | 3 |
| BCAR3 | CDC73 | 0.653112 | 3 | 0 | 3 |
| BCAR3 | STAM2 | 0.652048 | 3 | 0 | 3 |
| BCAR3 | ZNF212 | 0.647392 | 3 | 0 | 3 |
| BCAR3 | VPS4A | 0.642984 | 4 | 0 | 3 |
For details and further investigation, click here
