BCL11B

 

Full name: BAF chromatin remodeling complex subunit BCL11B Alias Symbol: CTIP-2|CTIP2|hRIT1-alpha
Type: protein-coding gene Cytoband: 14q32.2
Entrez ID: 64919 HGNC ID: HGNC:13222 Ensembl Gene: ENSG00000127152 OMIM ID: 606558
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of BCL11B:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 BCL11B 64919 222895_s_at 0.4783 0.7654
GSE20347 BCL11B 64919 219528_s_at 0.4266 0.1310
GSE23400 BCL11B 64919 219528_s_at 0.5285 0.0000
GSE26886 BCL11B 64919 222895_s_at -0.3707 0.3921
GSE29001 BCL11B 64919 219528_s_at 0.8356 0.0108
GSE38129 BCL11B 64919 219528_s_at 0.8208 0.0080
GSE45670 BCL11B 64919 222895_s_at 1.2165 0.0000
GSE53622 BCL11B 64919 89786 0.5462 0.0009
GSE53624 BCL11B 64919 89786 0.5981 0.0000
GSE63941 BCL11B 64919 222895_s_at 2.6816 0.0799
GSE77861 BCL11B 64919 219528_s_at 0.7678 0.0421
GSE97050 BCL11B 64919 A_23_P205738 0.4169 0.3103
SRP007169 BCL11B 64919 RNAseq 1.0781 0.0117
SRP008496 BCL11B 64919 RNAseq 0.8144 0.0017
SRP064894 BCL11B 64919 RNAseq 0.5144 0.1215
SRP133303 BCL11B 64919 RNAseq 0.6963 0.0025
SRP159526 BCL11B 64919 RNAseq 0.4122 0.4740
SRP193095 BCL11B 64919 RNAseq 0.3728 0.0407
SRP219564 BCL11B 64919 RNAseq 0.1147 0.8832
TCGA BCL11B 64919 RNAseq 1.1822 0.0000

Upregulated datasets: 3; Downregulated datasets: 0.  

 

Survival by BCL11B expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of BCL11B:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 BCL11B 64919 10 5 15
GSE20123 BCL11B 64919 10 4 16
GSE43470 BCL11B 64919 7 4 32
GSE46452 BCL11B 64919 17 3 39
GSE47630 BCL11B 64919 11 8 21
GSE54993 BCL11B 64919 3 8 59
GSE54994 BCL11B 64919 21 4 28
GSE60625 BCL11B 64919 0 2 9
GSE74703 BCL11B 64919 6 3 27
GSE74704 BCL11B 64919 6 3 11
TCGA BCL11B 64919 31 18 47

Total number of gains: 122; Total number of losses: 62; Total Number of normals: 304.  

 

Somatic mutations of BCL11B:

 

Generating mutation plots.

 

Highly correlated genes for BCL11B:

 

Showing top 20/377 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
BCL11BMYO1G0.690373303
BCL11BRNF1280.678093404
BCL11BC14orf1190.674272303
BCL11BRASEF0.666274403
BCL11BS100A70.640419605
BCL11BTP630.6391008
BCL11BLTB4R0.636082807
BCL11BCAPG0.633751604
BCL11BLAD10.62941403
BCL11BCECR20.628682403
BCL11BCLCA20.62665604
BCL11BDMKN0.626046404
BCL11BS100A80.622561303
BCL11BPERP0.622503
BCL11BKRT6B0.619427605
BCL11BDSP0.619194504
BCL11BMYO190.617389706
BCL11BCORO2A0.615007403
BCL11BFEN10.614449604
BCL11BF11R0.612883706

For details and further investigation, click here