| Full name: S100 calcium binding protein A8 | Alias Symbol: P8|MRP8|60B8AG|CGLA | ||
| Type: protein-coding gene | Cytoband: 1q21.3 | ||
| Entrez ID: 6279 | HGNC ID: HGNC:10498 | Ensembl Gene: ENSG00000143546 | OMIM ID: 123885 |
| Drug and gene relationship at DGIdb | |||
Expression of S100A8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | S100A8 | 6279 | 202917_s_at | -0.1058 | 0.7841 | |
| GSE20347 | S100A8 | 6279 | 202917_s_at | -1.0594 | 0.0609 | |
| GSE23400 | S100A8 | 6279 | 202917_s_at | -0.7817 | 0.0000 | |
| GSE26886 | S100A8 | 6279 | 202917_s_at | -3.8450 | 0.0002 | |
| GSE29001 | S100A8 | 6279 | 202917_s_at | -1.4707 | 0.1617 | |
| GSE38129 | S100A8 | 6279 | 202917_s_at | -0.4704 | 0.4842 | |
| GSE45670 | S100A8 | 6279 | 202917_s_at | -0.0108 | 0.9081 | |
| GSE53622 | S100A8 | 6279 | 12232 | -1.8793 | 0.0000 | |
| GSE53624 | S100A8 | 6279 | 12232 | -2.1085 | 0.0000 | |
| GSE63941 | S100A8 | 6279 | 202917_s_at | 3.0082 | 0.2685 | |
| GSE77861 | S100A8 | 6279 | 202917_s_at | -0.3247 | 0.0592 | |
| GSE97050 | S100A8 | 6279 | A_23_P434809 | -0.4720 | 0.5665 | |
| SRP007169 | S100A8 | 6279 | RNAseq | -7.7586 | 0.0000 | |
| SRP008496 | S100A8 | 6279 | RNAseq | -5.1062 | 0.0000 | |
| SRP064894 | S100A8 | 6279 | RNAseq | -2.8627 | 0.0000 | |
| SRP133303 | S100A8 | 6279 | RNAseq | -3.0238 | 0.0000 | |
| SRP159526 | S100A8 | 6279 | RNAseq | -3.9540 | 0.0000 | |
| SRP193095 | S100A8 | 6279 | RNAseq | -2.6087 | 0.0000 | |
| SRP219564 | S100A8 | 6279 | RNAseq | -3.6221 | 0.0078 | |
| TCGA | S100A8 | 6279 | RNAseq | 0.8471 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 10.
Survival by S100A8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of S100A8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | S100A8 | 6279 | 14 | 0 | 16 | |
| GSE20123 | S100A8 | 6279 | 14 | 0 | 16 | |
| GSE43470 | S100A8 | 6279 | 6 | 2 | 35 | |
| GSE46452 | S100A8 | 6279 | 2 | 1 | 56 | |
| GSE47630 | S100A8 | 6279 | 15 | 0 | 25 | |
| GSE54993 | S100A8 | 6279 | 0 | 4 | 66 | |
| GSE54994 | S100A8 | 6279 | 16 | 0 | 37 | |
| GSE60625 | S100A8 | 6279 | 0 | 0 | 11 | |
| GSE74703 | S100A8 | 6279 | 6 | 1 | 29 | |
| GSE74704 | S100A8 | 6279 | 7 | 0 | 13 | |
| TCGA | S100A8 | 6279 | 40 | 2 | 54 |
Total number of gains: 120; Total number of losses: 10; Total Number of normals: 358.
Somatic mutations of S100A8:
Generating mutation plots.
Highly correlated genes for S100A8:
Showing top 20/849 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| S100A8 | S100A9 | 0.931334 | 13 | 0 | 13 |
| S100A8 | TMPRSS11A | 0.82275 | 3 | 0 | 3 |
| S100A8 | SPRR2F | 0.809302 | 4 | 0 | 4 |
| S100A8 | SPRR2A | 0.804722 | 4 | 0 | 4 |
| S100A8 | CNFN | 0.789089 | 8 | 0 | 8 |
| S100A8 | SPRR2E | 0.787382 | 4 | 0 | 4 |
| S100A8 | KCNA7 | 0.779416 | 3 | 0 | 3 |
| S100A8 | SBSN | 0.775875 | 8 | 0 | 7 |
| S100A8 | SPRR2D | 0.771364 | 4 | 0 | 4 |
| S100A8 | OTOP3 | 0.764378 | 3 | 0 | 3 |
| S100A8 | NCCRP1 | 0.763703 | 4 | 0 | 4 |
| S100A8 | AQP3 | 0.761005 | 11 | 0 | 10 |
| S100A8 | SERPINB13 | 0.757186 | 10 | 0 | 10 |
| S100A8 | CD24 | 0.755891 | 10 | 0 | 10 |
| S100A8 | ANXA1 | 0.754116 | 11 | 0 | 10 |
| S100A8 | C5orf66-AS1 | 0.742953 | 5 | 0 | 5 |
| S100A8 | IL1RN | 0.742184 | 12 | 0 | 12 |
| S100A8 | FAM163B | 0.734763 | 3 | 0 | 3 |
| S100A8 | CSTB | 0.732206 | 12 | 0 | 12 |
| S100A8 | KPRP | 0.731105 | 3 | 0 | 3 |
For details and further investigation, click here
