| Full name: desmoplakin | Alias Symbol: KPPS2|PPKS2|DPI|DPII | ||
| Type: protein-coding gene | Cytoband: 6p24.3 | ||
| Entrez ID: 1832 | HGNC ID: HGNC:3052 | Ensembl Gene: ENSG00000096696 | OMIM ID: 125647 |
| Drug and gene relationship at DGIdb | |||
Expression of DSP:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DSP | 1832 | 200606_at | 0.0218 | 0.9801 | |
| GSE20347 | DSP | 1832 | 200606_at | -0.6638 | 0.0001 | |
| GSE23400 | DSP | 1832 | 200606_at | -0.1719 | 0.0936 | |
| GSE26886 | DSP | 1832 | 200606_at | -0.6509 | 0.0003 | |
| GSE29001 | DSP | 1832 | 200606_at | -0.2464 | 0.1062 | |
| GSE38129 | DSP | 1832 | 200606_at | 0.2619 | 0.5855 | |
| GSE45670 | DSP | 1832 | 200606_at | -0.0081 | 0.9440 | |
| GSE53622 | DSP | 1832 | 55912 | -0.3841 | 0.1980 | |
| GSE53624 | DSP | 1832 | 55912 | -1.0869 | 0.0000 | |
| GSE63941 | DSP | 1832 | 200606_at | 3.3455 | 0.0000 | |
| GSE77861 | DSP | 1832 | 200606_at | -0.3098 | 0.3112 | |
| GSE97050 | DSP | 1832 | A_33_P3402565 | 1.0275 | 0.4685 | |
| SRP007169 | DSP | 1832 | RNAseq | -0.8555 | 0.0140 | |
| SRP008496 | DSP | 1832 | RNAseq | -0.9488 | 0.0008 | |
| SRP064894 | DSP | 1832 | RNAseq | -1.3970 | 0.0019 | |
| SRP133303 | DSP | 1832 | RNAseq | -1.3723 | 0.0000 | |
| SRP159526 | DSP | 1832 | RNAseq | -1.5809 | 0.0000 | |
| SRP193095 | DSP | 1832 | RNAseq | -1.3543 | 0.0000 | |
| SRP219564 | DSP | 1832 | RNAseq | -1.4667 | 0.1921 | |
| TCGA | DSP | 1832 | RNAseq | 0.3696 | 0.0001 |
Upregulated datasets: 1; Downregulated datasets: 5.
Survival by DSP expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DSP:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DSP | 1832 | 4 | 5 | 21 | |
| GSE20123 | DSP | 1832 | 4 | 5 | 21 | |
| GSE43470 | DSP | 1832 | 8 | 2 | 33 | |
| GSE46452 | DSP | 1832 | 1 | 10 | 48 | |
| GSE47630 | DSP | 1832 | 7 | 8 | 25 | |
| GSE54993 | DSP | 1832 | 1 | 1 | 68 | |
| GSE54994 | DSP | 1832 | 10 | 3 | 40 | |
| GSE60625 | DSP | 1832 | 0 | 1 | 10 | |
| GSE74703 | DSP | 1832 | 7 | 2 | 27 | |
| GSE74704 | DSP | 1832 | 2 | 2 | 16 | |
| TCGA | DSP | 1832 | 15 | 28 | 53 |
Total number of gains: 59; Total number of losses: 67; Total Number of normals: 362.
Somatic mutations of DSP:
Generating mutation plots.
Highly correlated genes for DSP:
Showing top 20/786 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DSP | DSG3 | 0.787145 | 13 | 0 | 13 |
| DSP | PERP | 0.772785 | 12 | 0 | 12 |
| DSP | KRT6C | 0.761705 | 4 | 0 | 4 |
| DSP | MAL2 | 0.743848 | 9 | 0 | 8 |
| DSP | PKP1 | 0.739599 | 11 | 0 | 11 |
| DSP | DSC2 | 0.736042 | 13 | 0 | 11 |
| DSP | SPRYD4 | 0.734018 | 4 | 0 | 4 |
| DSP | S100A16 | 0.726656 | 8 | 0 | 7 |
| DSP | JUP | 0.719373 | 13 | 0 | 12 |
| DSP | SERPINB5 | 0.710532 | 12 | 0 | 11 |
| DSP | BTBD11 | 0.707781 | 7 | 0 | 7 |
| DSP | LAD1 | 0.706533 | 13 | 0 | 10 |
| DSP | DMKN | 0.704772 | 8 | 0 | 7 |
| DSP | COQ2 | 0.704748 | 4 | 0 | 4 |
| DSP | C3orf20 | 0.704051 | 4 | 0 | 4 |
| DSP | ARAP2 | 0.70362 | 4 | 0 | 4 |
| DSP | PKP3 | 0.70163 | 13 | 0 | 12 |
| DSP | SDC1 | 0.699048 | 11 | 0 | 10 |
| DSP | VAMP8 | 0.697957 | 11 | 0 | 11 |
| DSP | IL20RB | 0.697626 | 6 | 0 | 5 |
For details and further investigation, click here
