| Full name: beta-carotene oxygenase 2 | Alias Symbol: FLJ34464|B-DIOX-II | ||
| Type: protein-coding gene | Cytoband: 11q23.1 | ||
| Entrez ID: 83875 | HGNC ID: HGNC:18503 | Ensembl Gene: ENSG00000197580 | OMIM ID: 611740 |
| Drug and gene relationship at DGIdb | |||
Expression of BCO2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BCO2 | 83875 | 232449_at | -0.7114 | 0.2229 | |
| GSE26886 | BCO2 | 83875 | 232449_at | -2.7165 | 0.0000 | |
| GSE45670 | BCO2 | 83875 | 232449_at | -0.0486 | 0.9327 | |
| GSE53622 | BCO2 | 83875 | 58954 | -1.2755 | 0.0000 | |
| GSE53624 | BCO2 | 83875 | 58954 | -1.5405 | 0.0000 | |
| GSE63941 | BCO2 | 83875 | 232449_at | -0.4329 | 0.4463 | |
| GSE77861 | BCO2 | 83875 | 232449_at | -0.6785 | 0.0358 | |
| GSE97050 | BCO2 | 83875 | A_33_P3888485 | -0.3464 | 0.2151 | |
| SRP007169 | BCO2 | 83875 | RNAseq | -3.1798 | 0.0004 | |
| SRP064894 | BCO2 | 83875 | RNAseq | -1.9672 | 0.0000 | |
| SRP133303 | BCO2 | 83875 | RNAseq | -1.4584 | 0.0000 | |
| SRP159526 | BCO2 | 83875 | RNAseq | -1.7949 | 0.0011 | |
| SRP193095 | BCO2 | 83875 | RNAseq | -2.0896 | 0.0000 | |
| SRP219564 | BCO2 | 83875 | RNAseq | -1.8574 | 0.0012 | |
| TCGA | BCO2 | 83875 | RNAseq | -0.2409 | 0.3570 |
Upregulated datasets: 0; Downregulated datasets: 9.
Survival by BCO2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of BCO2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BCO2 | 83875 | 0 | 12 | 18 | |
| GSE20123 | BCO2 | 83875 | 0 | 12 | 18 | |
| GSE43470 | BCO2 | 83875 | 2 | 6 | 35 | |
| GSE46452 | BCO2 | 83875 | 3 | 26 | 30 | |
| GSE47630 | BCO2 | 83875 | 2 | 19 | 19 | |
| GSE54993 | BCO2 | 83875 | 10 | 0 | 60 | |
| GSE54994 | BCO2 | 83875 | 5 | 19 | 29 | |
| GSE60625 | BCO2 | 83875 | 0 | 3 | 8 | |
| GSE74703 | BCO2 | 83875 | 1 | 4 | 31 | |
| GSE74704 | BCO2 | 83875 | 0 | 8 | 12 | |
| TCGA | BCO2 | 83875 | 7 | 48 | 41 |
Total number of gains: 30; Total number of losses: 157; Total Number of normals: 301.
Somatic mutations of BCO2:
Generating mutation plots.
Highly correlated genes for BCO2:
Showing top 20/854 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BCO2 | IL18 | 0.740609 | 6 | 0 | 5 |
| BCO2 | RETSAT | 0.737084 | 3 | 0 | 3 |
| BCO2 | SPAG17 | 0.718193 | 5 | 0 | 5 |
| BCO2 | NDUFV2-AS1 | 0.707169 | 3 | 0 | 3 |
| BCO2 | VSIG10L | 0.702781 | 7 | 0 | 7 |
| BCO2 | GPX6 | 0.700403 | 3 | 0 | 3 |
| BCO2 | CWH43 | 0.700011 | 5 | 0 | 5 |
| BCO2 | RAET1E | 0.699928 | 7 | 0 | 7 |
| BCO2 | SLC7A4 | 0.695259 | 4 | 0 | 4 |
| BCO2 | EPS8L2 | 0.694414 | 7 | 0 | 7 |
| BCO2 | AIF1L | 0.694103 | 7 | 0 | 7 |
| BCO2 | PLD1 | 0.693408 | 6 | 0 | 6 |
| BCO2 | SLURP1 | 0.693043 | 7 | 0 | 7 |
| BCO2 | CRNN | 0.691461 | 7 | 0 | 7 |
| BCO2 | ANXA9 | 0.689397 | 6 | 0 | 6 |
| BCO2 | ACPP | 0.689106 | 7 | 0 | 7 |
| BCO2 | NCCRP1 | 0.687694 | 3 | 0 | 3 |
| BCO2 | MAL | 0.686981 | 7 | 0 | 7 |
| BCO2 | SCNN1B | 0.685551 | 7 | 0 | 7 |
| BCO2 | SCEL | 0.685069 | 7 | 0 | 7 |
For details and further investigation, click here
