| Full name: brain derived neurotrophic factor | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 11p14.1 | ||
| Entrez ID: 627 | HGNC ID: HGNC:1033 | Ensembl Gene: ENSG00000176697 | OMIM ID: 113505 |
| Drug and gene relationship at DGIdb | |||
BDNF involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04010 | MAPK signaling pathway | |
| hsa04024 | cAMP signaling pathway | |
| hsa04722 | Neurotrophin signaling pathway | |
| hsa05030 | Cocaine addiction | |
| hsa05034 | Alcoholism |
Expression of BDNF:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BDNF | 627 | 206382_s_at | -0.1164 | 0.8501 | |
| GSE20347 | BDNF | 627 | 206382_s_at | 0.1650 | 0.5015 | |
| GSE23400 | BDNF | 627 | 206382_s_at | 0.0730 | 0.0642 | |
| GSE26886 | BDNF | 627 | 239367_at | 0.5933 | 0.0490 | |
| GSE29001 | BDNF | 627 | 206382_s_at | 0.0653 | 0.9023 | |
| GSE38129 | BDNF | 627 | 206382_s_at | 0.4249 | 0.0617 | |
| GSE45670 | BDNF | 627 | 206382_s_at | 0.7526 | 0.1719 | |
| GSE53622 | BDNF | 627 | 71586 | 0.8870 | 0.0000 | |
| GSE53624 | BDNF | 627 | 33274 | 0.8266 | 0.0000 | |
| GSE63941 | BDNF | 627 | 239367_at | -4.2367 | 0.0000 | |
| GSE77861 | BDNF | 627 | 239367_at | 0.2172 | 0.2684 | |
| GSE97050 | BDNF | 627 | A_23_P127891 | -0.1834 | 0.3719 | |
| SRP007169 | BDNF | 627 | RNAseq | 1.3280 | 0.0815 | |
| SRP064894 | BDNF | 627 | RNAseq | 0.4557 | 0.3302 | |
| SRP133303 | BDNF | 627 | RNAseq | 0.2528 | 0.5936 | |
| SRP159526 | BDNF | 627 | RNAseq | 1.3675 | 0.0042 | |
| SRP193095 | BDNF | 627 | RNAseq | 0.5513 | 0.0251 | |
| SRP219564 | BDNF | 627 | RNAseq | 1.3502 | 0.1726 | |
| TCGA | BDNF | 627 | RNAseq | 0.6267 | 0.0502 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by BDNF expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of BDNF:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BDNF | 627 | 1 | 9 | 20 | |
| GSE20123 | BDNF | 627 | 1 | 8 | 21 | |
| GSE43470 | BDNF | 627 | 1 | 5 | 37 | |
| GSE46452 | BDNF | 627 | 6 | 6 | 47 | |
| GSE47630 | BDNF | 627 | 3 | 10 | 27 | |
| GSE54993 | BDNF | 627 | 3 | 0 | 67 | |
| GSE54994 | BDNF | 627 | 4 | 11 | 38 | |
| GSE60625 | BDNF | 627 | 0 | 0 | 11 | |
| GSE74703 | BDNF | 627 | 1 | 3 | 32 | |
| GSE74704 | BDNF | 627 | 0 | 8 | 12 | |
| TCGA | BDNF | 627 | 12 | 24 | 60 |
Total number of gains: 32; Total number of losses: 84; Total Number of normals: 372.
Somatic mutations of BDNF:
Generating mutation plots.
Highly correlated genes for BDNF:
Showing top 20/174 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BDNF | ZNF407 | 0.760833 | 3 | 0 | 3 |
| BDNF | SGCD | 0.758453 | 3 | 0 | 3 |
| BDNF | SCUBE3 | 0.73493 | 5 | 0 | 5 |
| BDNF | TRAPPC12 | 0.727017 | 3 | 0 | 3 |
| BDNF | HSF2 | 0.726055 | 3 | 0 | 3 |
| BDNF | EML1 | 0.722015 | 3 | 0 | 3 |
| BDNF | SPATA9 | 0.716941 | 3 | 0 | 3 |
| BDNF | MAP9 | 0.715536 | 3 | 0 | 3 |
| BDNF | MRAP2 | 0.715362 | 4 | 0 | 4 |
| BDNF | ADAM32 | 0.714207 | 3 | 0 | 3 |
| BDNF | ZNF516 | 0.713743 | 3 | 0 | 3 |
| BDNF | C6orf120 | 0.709068 | 3 | 0 | 3 |
| BDNF | DPY19L2 | 0.707253 | 4 | 0 | 3 |
| BDNF | SRSF12 | 0.701696 | 3 | 0 | 3 |
| BDNF | EEPD1 | 0.699083 | 4 | 0 | 4 |
| BDNF | SOX2-OT | 0.697843 | 4 | 0 | 3 |
| BDNF | ADAMTS12 | 0.69779 | 3 | 0 | 3 |
| BDNF | STK32B | 0.692913 | 4 | 0 | 3 |
| BDNF | AGPAT4 | 0.692557 | 3 | 0 | 3 |
| BDNF | MTRF1L | 0.689328 | 3 | 0 | 3 |
For details and further investigation, click here
