| Full name: serine and arginine rich splicing factor 12 | Alias Symbol: SRrp35|SFRS19 | ||
| Type: protein-coding gene | Cytoband: 6q15 | ||
| Entrez ID: 135295 | HGNC ID: HGNC:21220 | Ensembl Gene: ENSG00000154548 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of SRSF12:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SRSF12 | 135295 | 239295_at | 0.0416 | 0.8880 | |
| GSE26886 | SRSF12 | 135295 | 239295_at | 0.0877 | 0.5080 | |
| GSE45670 | SRSF12 | 135295 | 239295_at | 0.1048 | 0.7004 | |
| GSE53622 | SRSF12 | 135295 | 104029 | 0.4455 | 0.0104 | |
| GSE53624 | SRSF12 | 135295 | 104029 | 0.6651 | 0.0003 | |
| GSE63941 | SRSF12 | 135295 | 239295_at | -0.0455 | 0.9378 | |
| GSE77861 | SRSF12 | 135295 | 239295_at | 0.0406 | 0.7821 | |
| GSE97050 | SRSF12 | 135295 | A_32_P456318 | -0.4222 | 0.2452 | |
| SRP064894 | SRSF12 | 135295 | RNAseq | 0.7512 | 0.0083 | |
| SRP133303 | SRSF12 | 135295 | RNAseq | 0.1905 | 0.4409 | |
| SRP159526 | SRSF12 | 135295 | RNAseq | 2.0127 | 0.0000 | |
| SRP193095 | SRSF12 | 135295 | RNAseq | 0.2509 | 0.1039 | |
| SRP219564 | SRSF12 | 135295 | RNAseq | 1.0781 | 0.0340 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by SRSF12 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of SRSF12:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SRSF12 | 135295 | 1 | 4 | 25 | |
| GSE20123 | SRSF12 | 135295 | 1 | 3 | 26 | |
| GSE43470 | SRSF12 | 135295 | 3 | 1 | 39 | |
| GSE46452 | SRSF12 | 135295 | 2 | 11 | 46 | |
| GSE47630 | SRSF12 | 135295 | 8 | 6 | 26 | |
| GSE54993 | SRSF12 | 135295 | 3 | 2 | 65 | |
| GSE54994 | SRSF12 | 135295 | 8 | 8 | 37 | |
| GSE60625 | SRSF12 | 135295 | 0 | 1 | 10 | |
| GSE74703 | SRSF12 | 135295 | 3 | 1 | 32 | |
| GSE74704 | SRSF12 | 135295 | 0 | 2 | 18 | |
| TCGA | SRSF12 | 135295 | 8 | 21 | 67 |
Total number of gains: 37; Total number of losses: 60; Total Number of normals: 391.
Somatic mutations of SRSF12:
Generating mutation plots.
Highly correlated genes for SRSF12:
Showing top 20/72 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SRSF12 | RBM12 | 0.706347 | 3 | 0 | 3 |
| SRSF12 | BDNF | 0.701696 | 3 | 0 | 3 |
| SRSF12 | SPATA9 | 0.699621 | 4 | 0 | 4 |
| SRSF12 | C11orf71 | 0.697183 | 3 | 0 | 3 |
| SRSF12 | BIN2 | 0.69418 | 3 | 0 | 3 |
| SRSF12 | ZNF510 | 0.690726 | 3 | 0 | 3 |
| SRSF12 | FAM167B | 0.664666 | 3 | 0 | 3 |
| SRSF12 | C12orf73 | 0.663046 | 3 | 0 | 3 |
| SRSF12 | TCTN1 | 0.659697 | 3 | 0 | 3 |
| SRSF12 | FBXO21 | 0.646147 | 3 | 0 | 3 |
| SRSF12 | SERPINA12 | 0.63956 | 3 | 0 | 3 |
| SRSF12 | HLA-DMB | 0.637759 | 3 | 0 | 3 |
| SRSF12 | IRF8 | 0.635482 | 3 | 0 | 3 |
| SRSF12 | BCAS4 | 0.634945 | 3 | 0 | 3 |
| SRSF12 | RNF7 | 0.633311 | 3 | 0 | 3 |
| SRSF12 | ITGAE | 0.629844 | 4 | 0 | 3 |
| SRSF12 | CEP70 | 0.629452 | 4 | 0 | 3 |
| SRSF12 | RAB39B | 0.627827 | 5 | 0 | 4 |
| SRSF12 | ALDH1A1 | 0.619713 | 3 | 0 | 3 |
| SRSF12 | ALDH18A1 | 0.610422 | 3 | 0 | 3 |
For details and further investigation, click here
