| Full name: dynein cytoplasmic 2 heavy chain 1 | Alias Symbol: hdhc11|DHC2|DHC1b|DYH1B | ||
| Type: protein-coding gene | Cytoband: 11q22.3 | ||
| Entrez ID: 79659 | HGNC ID: HGNC:2962 | Ensembl Gene: ENSG00000187240 | OMIM ID: 603297 |
| Drug and gene relationship at DGIdb | |||
Expression of DYNC2H1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DYNC2H1 | 79659 | 219469_at | -0.0960 | 0.8685 | |
| GSE20347 | DYNC2H1 | 79659 | 219469_at | 0.6396 | 0.0744 | |
| GSE23400 | DYNC2H1 | 79659 | 219469_at | 0.2664 | 0.0310 | |
| GSE26886 | DYNC2H1 | 79659 | 219469_at | 1.0129 | 0.0012 | |
| GSE29001 | DYNC2H1 | 79659 | 219469_at | 0.0082 | 0.9770 | |
| GSE38129 | DYNC2H1 | 79659 | 219469_at | 0.3165 | 0.1953 | |
| GSE45670 | DYNC2H1 | 79659 | 219469_at | -0.1541 | 0.6794 | |
| GSE53622 | DYNC2H1 | 79659 | 44366 | 0.0643 | 0.6608 | |
| GSE53624 | DYNC2H1 | 79659 | 44366 | 0.1385 | 0.3694 | |
| GSE63941 | DYNC2H1 | 79659 | 219469_at | -1.7142 | 0.1733 | |
| GSE77861 | DYNC2H1 | 79659 | 219469_at | 0.2112 | 0.2886 | |
| GSE97050 | DYNC2H1 | 79659 | A_23_P147397 | 0.0905 | 0.8470 | |
| SRP008496 | DYNC2H1 | 79659 | RNAseq | 2.4200 | 0.0013 | |
| SRP064894 | DYNC2H1 | 79659 | RNAseq | 1.1966 | 0.0040 | |
| SRP133303 | DYNC2H1 | 79659 | RNAseq | -0.0355 | 0.8751 | |
| SRP159526 | DYNC2H1 | 79659 | RNAseq | -0.0021 | 0.9921 | |
| SRP193095 | DYNC2H1 | 79659 | RNAseq | 0.0952 | 0.5463 | |
| SRP219564 | DYNC2H1 | 79659 | RNAseq | -0.1006 | 0.8951 | |
| TCGA | DYNC2H1 | 79659 | RNAseq | -0.0377 | 0.7665 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by DYNC2H1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DYNC2H1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DYNC2H1 | 79659 | 4 | 8 | 18 | |
| GSE20123 | DYNC2H1 | 79659 | 5 | 8 | 17 | |
| GSE43470 | DYNC2H1 | 79659 | 5 | 5 | 33 | |
| GSE46452 | DYNC2H1 | 79659 | 5 | 24 | 30 | |
| GSE47630 | DYNC2H1 | 79659 | 2 | 19 | 19 | |
| GSE54993 | DYNC2H1 | 79659 | 9 | 1 | 60 | |
| GSE54994 | DYNC2H1 | 79659 | 6 | 18 | 29 | |
| GSE60625 | DYNC2H1 | 79659 | 0 | 3 | 8 | |
| GSE74703 | DYNC2H1 | 79659 | 3 | 4 | 29 | |
| GSE74704 | DYNC2H1 | 79659 | 5 | 4 | 11 | |
| TCGA | DYNC2H1 | 79659 | 10 | 44 | 42 |
Total number of gains: 54; Total number of losses: 138; Total Number of normals: 296.
Somatic mutations of DYNC2H1:
Generating mutation plots.
Highly correlated genes for DYNC2H1:
Showing top 20/435 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DYNC2H1 | SMARCAL1 | 0.802392 | 3 | 0 | 3 |
| DYNC2H1 | TOP1MT | 0.791731 | 3 | 0 | 3 |
| DYNC2H1 | PLOD3 | 0.779489 | 3 | 0 | 3 |
| DYNC2H1 | DNAJC11 | 0.769354 | 3 | 0 | 3 |
| DYNC2H1 | DNMBP | 0.766088 | 3 | 0 | 3 |
| DYNC2H1 | UTP23 | 0.758875 | 3 | 0 | 3 |
| DYNC2H1 | ZNF496 | 0.754836 | 3 | 0 | 3 |
| DYNC2H1 | BRI3 | 0.752035 | 3 | 0 | 3 |
| DYNC2H1 | SMYD2 | 0.737509 | 4 | 0 | 4 |
| DYNC2H1 | SLC39A1 | 0.725914 | 3 | 0 | 3 |
| DYNC2H1 | SETD2 | 0.725637 | 3 | 0 | 3 |
| DYNC2H1 | SORBS3 | 0.720952 | 3 | 0 | 3 |
| DYNC2H1 | SCCPDH | 0.718072 | 3 | 0 | 3 |
| DYNC2H1 | DDX55 | 0.714172 | 3 | 0 | 3 |
| DYNC2H1 | LIN52 | 0.711833 | 4 | 0 | 4 |
| DYNC2H1 | USP42 | 0.711748 | 3 | 0 | 3 |
| DYNC2H1 | EIF2D | 0.711341 | 4 | 0 | 3 |
| DYNC2H1 | PPTC7 | 0.706225 | 3 | 0 | 3 |
| DYNC2H1 | KDM4A | 0.70472 | 3 | 0 | 3 |
| DYNC2H1 | PARVB | 0.70315 | 3 | 0 | 3 |
For details and further investigation, click here
