EIF4EBP1

 

Full name: eukaryotic translation initiation factor 4E binding protein 1 Alias Symbol: PHAS-I|4E-BP1
Type: protein-coding gene Cytoband: 8p11.23
Entrez ID: 1978 HGNC ID: HGNC:3288 Ensembl Gene: ENSG00000187840 OMIM ID: 602223
Drug and gene relationship at DGIdb

 

EIF4EBP1 involved pathways:

KEGG pathway Description View
hsa04012ErbB signaling pathway
hsa04066HIF-1 signaling pathway
hsa04150mTOR signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04152AMPK signaling pathway
hsa04211Longevity regulating pathway - mammal
hsa04910Insulin signaling pathway
hsa05221Acute myeloid leukemia
hsa05231Choline metabolism in cancer

 

Expression of EIF4EBP1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 EIF4EBP1 1978 221539_at 0.4070 0.3825
GSE20347 EIF4EBP1 1978 221539_at 0.4105 0.0856
GSE23400 EIF4EBP1 1978 221539_at 0.7243 0.0000
GSE26886 EIF4EBP1 1978 221539_at 1.1550 0.0000
GSE29001 EIF4EBP1 1978 221539_at 0.1815 0.6126
GSE38129 EIF4EBP1 1978 221539_at 0.7258 0.0014
GSE45670 EIF4EBP1 1978 221539_at 0.1373 0.6265
GSE53622 EIF4EBP1 1978 72032 0.7125 0.0000
GSE53624 EIF4EBP1 1978 72032 0.6957 0.0000
GSE63941 EIF4EBP1 1978 221539_at 2.0575 0.0169
GSE77861 EIF4EBP1 1978 221539_at 0.1977 0.6311
GSE97050 EIF4EBP1 1978 A_23_P22224 0.7695 0.2727
SRP007169 EIF4EBP1 1978 RNAseq -0.2994 0.5452
SRP008496 EIF4EBP1 1978 RNAseq -0.7738 0.0207
SRP064894 EIF4EBP1 1978 RNAseq 0.6128 0.0650
SRP133303 EIF4EBP1 1978 RNAseq 0.6231 0.0022
SRP159526 EIF4EBP1 1978 RNAseq 0.4379 0.3771
SRP193095 EIF4EBP1 1978 RNAseq 0.5185 0.0291
SRP219564 EIF4EBP1 1978 RNAseq 0.4180 0.3011
TCGA EIF4EBP1 1978 RNAseq 0.4102 0.0000

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by EIF4EBP1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of EIF4EBP1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 EIF4EBP1 1978 9 4 17
GSE20123 EIF4EBP1 1978 10 4 16
GSE43470 EIF4EBP1 1978 8 7 28
GSE46452 EIF4EBP1 1978 23 4 32
GSE47630 EIF4EBP1 1978 12 7 21
GSE54993 EIF4EBP1 1978 2 16 52
GSE54994 EIF4EBP1 1978 16 8 29
GSE60625 EIF4EBP1 1978 3 0 8
GSE74703 EIF4EBP1 1978 8 5 23
GSE74704 EIF4EBP1 1978 8 1 11
TCGA EIF4EBP1 1978 35 25 36

Total number of gains: 134; Total number of losses: 81; Total Number of normals: 273.  

 

Somatic mutations of EIF4EBP1:

 

Generating mutation plots.

 

Highly correlated genes for EIF4EBP1:

 

Showing top 20/568 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
EIF4EBP1RCC20.686961504
EIF4EBP1FPGS0.666655303
EIF4EBP1EME10.651919505
EIF4EBP1CENPW0.650305504
EIF4EBP1BIN30.649709604
EIF4EBP1BMP10.646868504
EIF4EBP1CHTF180.645717303
EIF4EBP1XPO50.644841606
EIF4EBP1GTSE10.644752404
EIF4EBP1REEP40.644167705
EIF4EBP1TPM30.643106404
EIF4EBP1STRA60.642144303
EIF4EBP1SYT70.639311403
EIF4EBP1PTPRH0.63162303
EIF4EBP1SHMT20.6279661009
EIF4EBP1FANCI0.623538806
EIF4EBP1FKBP90.621103303
EIF4EBP1SLCO1B30.61914504
EIF4EBP1DUS1L0.61868907
EIF4EBP1BOP10.616644303

For details and further investigation, click here