DSG2

 

Full name: desmoglein 2 Alias Symbol: CDHF5
Type: protein-coding gene Cytoband: 18q12.1
Entrez ID: 1829 HGNC ID: HGNC:3049 Ensembl Gene: ENSG00000046604 OMIM ID: 125671
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of DSG2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 DSG2 1829 217901_at 1.4284 0.0639
GSE20347 DSG2 1829 217901_at 1.4622 0.0000
GSE23400 DSG2 1829 217901_at 1.3692 0.0000
GSE26886 DSG2 1829 217901_at 0.8945 0.0035
GSE29001 DSG2 1829 217901_at 0.9860 0.0079
GSE38129 DSG2 1829 217901_at 1.8978 0.0000
GSE45670 DSG2 1829 217901_at 1.1579 0.0005
GSE53622 DSG2 1829 3711 1.8328 0.0000
GSE53624 DSG2 1829 3711 1.3879 0.0000
GSE63941 DSG2 1829 217901_at 3.4941 0.0015
GSE77861 DSG2 1829 217901_at 1.6170 0.0006
GSE97050 DSG2 1829 A_23_P141730 1.8756 0.1849
SRP007169 DSG2 1829 RNAseq 2.4004 0.0003
SRP008496 DSG2 1829 RNAseq 2.1279 0.0000
SRP064894 DSG2 1829 RNAseq 0.7763 0.0265
SRP133303 DSG2 1829 RNAseq 1.8364 0.0000
SRP159526 DSG2 1829 RNAseq 1.9162 0.0010
SRP193095 DSG2 1829 RNAseq 0.3533 0.2889
SRP219564 DSG2 1829 RNAseq 1.4378 0.1017
TCGA DSG2 1829 RNAseq 0.1456 0.1012

Upregulated datasets: 12; Downregulated datasets: 0.  

 

Survival by DSG2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of DSG2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 DSG2 1829 2 6 22
GSE20123 DSG2 1829 2 6 22
GSE43470 DSG2 1829 0 2 41
GSE46452 DSG2 1829 1 25 33
GSE47630 DSG2 1829 5 20 15
GSE54993 DSG2 1829 7 1 62
GSE54994 DSG2 1829 2 16 35
GSE60625 DSG2 1829 0 4 7
GSE74703 DSG2 1829 0 2 34
GSE74704 DSG2 1829 0 5 15
TCGA DSG2 1829 14 36 46

Total number of gains: 33; Total number of losses: 123; Total Number of normals: 332.  

 

Somatic mutations of DSG2:

 

Generating mutation plots.

 

Highly correlated genes for DSG2:

 

Showing top 20/1393 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
DSG2AP1S30.782679303
DSG2TPX20.75508712012
DSG2KIF140.74400112011
DSG2FOXO10.735003303
DSG2UHRF10.734958707
DSG2LAMB30.72917812012
DSG2CKS1B0.72022412011
DSG2ZNRD10.715575303
DSG2KPNA20.711576908
DSG2ILF20.71152111010
DSG2PLK10.71134311011
DSG2AURKB0.70867612012
DSG2CENPF0.7075313011
DSG2UBE2T0.705981808
DSG2KIF18B0.70451810010
DSG2RAD51AP10.70383312011
DSG2KIF20A0.70332912011
DSG2EPCAM0.7025513011
DSG2NEK20.70250113012
DSG2TSEN540.702264403

For details and further investigation, click here