| Full name: ceramide synthase 4 | Alias Symbol: FLJ12089|Trh1 | ||
| Type: protein-coding gene | Cytoband: 19p13.2 | ||
| Entrez ID: 79603 | HGNC ID: HGNC:23747 | Ensembl Gene: ENSG00000090661 | OMIM ID: 615334 |
| Drug and gene relationship at DGIdb | |||
Expression of CERS4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CERS4 | 79603 | 218922_s_at | -0.5801 | 0.5751 | |
| GSE20347 | CERS4 | 79603 | 218922_s_at | -0.9633 | 0.0001 | |
| GSE23400 | CERS4 | 79603 | 218922_s_at | -0.4037 | 0.0000 | |
| GSE26886 | CERS4 | 79603 | 218922_s_at | -0.2274 | 0.2145 | |
| GSE29001 | CERS4 | 79603 | 218922_s_at | -0.8734 | 0.0079 | |
| GSE38129 | CERS4 | 79603 | 218922_s_at | -0.5671 | 0.0079 | |
| GSE45670 | CERS4 | 79603 | 218922_s_at | 0.1925 | 0.2329 | |
| GSE53622 | CERS4 | 79603 | 28441 | -1.0200 | 0.0000 | |
| GSE53624 | CERS4 | 79603 | 28441 | -1.0606 | 0.0000 | |
| GSE63941 | CERS4 | 79603 | 218922_s_at | 1.0396 | 0.1767 | |
| GSE77861 | CERS4 | 79603 | 218922_s_at | -0.2801 | 0.2623 | |
| GSE97050 | CERS4 | 79603 | A_23_P153867 | -0.2030 | 0.3981 | |
| SRP007169 | CERS4 | 79603 | RNAseq | -2.1255 | 0.0000 | |
| SRP008496 | CERS4 | 79603 | RNAseq | -2.4294 | 0.0000 | |
| SRP064894 | CERS4 | 79603 | RNAseq | -1.2650 | 0.0002 | |
| SRP133303 | CERS4 | 79603 | RNAseq | -1.3367 | 0.0000 | |
| SRP159526 | CERS4 | 79603 | RNAseq | -0.7576 | 0.0819 | |
| SRP193095 | CERS4 | 79603 | RNAseq | -0.5865 | 0.0346 | |
| SRP219564 | CERS4 | 79603 | RNAseq | -0.7408 | 0.1483 |
Upregulated datasets: 0; Downregulated datasets: 6.
Survival by CERS4 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of CERS4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CERS4 | 79603 | 4 | 3 | 23 | |
| GSE20123 | CERS4 | 79603 | 3 | 2 | 25 | |
| GSE43470 | CERS4 | 79603 | 2 | 6 | 35 | |
| GSE46452 | CERS4 | 79603 | 47 | 1 | 11 | |
| GSE47630 | CERS4 | 79603 | 5 | 7 | 28 | |
| GSE54993 | CERS4 | 79603 | 16 | 3 | 51 | |
| GSE54994 | CERS4 | 79603 | 6 | 14 | 33 | |
| GSE60625 | CERS4 | 79603 | 9 | 0 | 2 | |
| GSE74703 | CERS4 | 79603 | 2 | 4 | 30 | |
| GSE74704 | CERS4 | 79603 | 0 | 2 | 18 | |
| TCGA | CERS4 | 79603 | 10 | 19 | 67 |
Total number of gains: 104; Total number of losses: 61; Total Number of normals: 323.
Somatic mutations of CERS4:
Generating mutation plots.
Highly correlated genes for CERS4:
Showing top 20/953 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CERS4 | WDR47 | 0.78285 | 3 | 0 | 3 |
| CERS4 | DDI2 | 0.782546 | 3 | 0 | 3 |
| CERS4 | BLOC1S2 | 0.753756 | 3 | 0 | 3 |
| CERS4 | HSBP1L1 | 0.717108 | 5 | 0 | 4 |
| CERS4 | ASPG | 0.714891 | 4 | 0 | 4 |
| CERS4 | NIPAL1 | 0.71438 | 3 | 0 | 3 |
| CERS4 | EPGN | 0.710509 | 3 | 0 | 3 |
| CERS4 | REEP5 | 0.70908 | 3 | 0 | 3 |
| CERS4 | COMMD9 | 0.705558 | 3 | 0 | 3 |
| CERS4 | DNAJB7 | 0.705251 | 3 | 0 | 3 |
| CERS4 | ARHGAP27 | 0.70499 | 6 | 0 | 6 |
| CERS4 | NUAK2 | 0.700318 | 3 | 0 | 3 |
| CERS4 | NCK1 | 0.699434 | 3 | 0 | 3 |
| CERS4 | C5orf66-AS1 | 0.696772 | 3 | 0 | 3 |
| CERS4 | FAHD1 | 0.695197 | 3 | 0 | 3 |
| CERS4 | MRPL30 | 0.69461 | 3 | 0 | 3 |
| CERS4 | SLC16A6 | 0.694076 | 9 | 0 | 9 |
| CERS4 | GTF3C1 | 0.69297 | 9 | 0 | 8 |
| CERS4 | ELOVL1 | 0.691121 | 3 | 0 | 3 |
| CERS4 | MUC15 | 0.689163 | 4 | 0 | 4 |
For details and further investigation, click here
