PDGFRB

 

Full name: platelet derived growth factor receptor beta Alias Symbol: JTK12|CD140b|PDGFR1
Type: protein-coding gene Cytoband: 5q32
Entrez ID: 5159 HGNC ID: HGNC:8804 Ensembl Gene: ENSG00000113721 OMIM ID: 173410
Drug and gene relationship at DGIdb

 

PDGFRB involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
hsa04020Calcium signaling pathway
hsa04072Phospholipase D signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04510Focal adhesion
hsa04540Gap junction
hsa04810Regulation of actin cytoskeleton
hsa05166HTLV-I infection
hsa05200Pathways in cancer
hsa05214Glioma
hsa05215Prostate cancer
hsa05218Melanoma
hsa05231Choline metabolism in cancer

 

Expression of PDGFRB:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PDGFRB 5159 202273_at 0.6175 0.3774
GSE20347 PDGFRB 5159 202273_at 0.6873 0.0002
GSE23400 PDGFRB 5159 202273_at 0.4127 0.0000
GSE26886 PDGFRB 5159 202273_at 1.1381 0.0000
GSE29001 PDGFRB 5159 202273_at 0.2584 0.1396
GSE38129 PDGFRB 5159 202273_at 0.5346 0.0128
GSE45670 PDGFRB 5159 202273_at -0.3355 0.3483
GSE53622 PDGFRB 5159 5512 0.6292 0.0000
GSE53624 PDGFRB 5159 5512 0.3079 0.0000
GSE63941 PDGFRB 5159 202273_at -4.2324 0.0000
GSE77861 PDGFRB 5159 202273_at 0.3158 0.1222
GSE97050 PDGFRB 5159 A_23_P421401 0.8981 0.0620
SRP007169 PDGFRB 5159 RNAseq 3.2138 0.0000
SRP008496 PDGFRB 5159 RNAseq 3.6964 0.0000
SRP064894 PDGFRB 5159 RNAseq 1.3269 0.0000
SRP133303 PDGFRB 5159 RNAseq 1.0753 0.0004
SRP159526 PDGFRB 5159 RNAseq 0.4143 0.2068
SRP193095 PDGFRB 5159 RNAseq 2.8471 0.0000
SRP219564 PDGFRB 5159 RNAseq 1.1741 0.0139
TCGA PDGFRB 5159 RNAseq 0.1873 0.0581

Upregulated datasets: 7; Downregulated datasets: 1.  

 

Survival by PDGFRB expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PDGFRB:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PDGFRB 5159 1 12 17
GSE20123 PDGFRB 5159 1 12 17
GSE43470 PDGFRB 5159 1 10 32
GSE46452 PDGFRB 5159 0 27 32
GSE47630 PDGFRB 5159 0 20 20
GSE54993 PDGFRB 5159 9 1 60
GSE54994 PDGFRB 5159 2 15 36
GSE60625 PDGFRB 5159 0 0 11
GSE74703 PDGFRB 5159 1 7 28
GSE74704 PDGFRB 5159 1 7 12
TCGA PDGFRB 5159 5 38 53

Total number of gains: 21; Total number of losses: 149; Total Number of normals: 318.  

 

Somatic mutations of PDGFRB:

 

Generating mutation plots.

 

Highly correlated genes for PDGFRB:

 

Showing top 20/1181 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PDGFRBPCOLCE0.82561813012
PDGFRBCTSK0.82487212012
PDGFRBC11orf960.810488404
PDGFRBVCAN0.80326612012
PDGFRBCOL6A30.79797113012
PDGFRBANGPTL20.79787313013
PDGFRBCOL6A20.79697512012
PDGFRBMMP20.79088112012
PDGFRBSPARC0.7907313012
PDGFRBRFTN20.788442303
PDGFRBFAP0.78699511011
PDGFRBCHN10.78251912012
PDGFRBCOL1A20.78075912012
PDGFRBCOL6A10.78028913012
PDGFRBTHY10.77789513012
PDGFRBHGF0.776837303
PDGFRBKDSR0.776653303
PDGFRBTNFAIP60.77481412012
PDGFRBALKBH60.768968303
PDGFRBCOL5A10.7645213012

For details and further investigation, click here