MGA

 

Full name: MAX dimerization protein MGA Alias Symbol: KIAA0518|MAD5|MXD5|FLJ12634
Type: protein-coding gene Cytoband: 15q15
Entrez ID: 23269 HGNC ID: HGNC:14010 Ensembl Gene: ENSG00000174197 OMIM ID: 616061
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of MGA:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE20347 MGA 23269 212945_s_at 0.1091 0.4063
GSE23400 MGA 23269 212945_s_at 0.0795 0.1864
GSE29001 MGA 23269 212945_s_at -0.0271 0.9566
GSE38129 MGA 23269 212945_s_at 0.1708 0.0706
GSE45670 MGA 23269 212945_s_at 0.1636 0.2460
GSE53622 MGA 23269 22318 0.3580 0.0000
GSE53624 MGA 23269 104205 0.1619 0.0041
GSE97050 MGA 23269 A_33_P3330323 0.0261 0.9111
SRP007169 MGA 23269 RNAseq 0.3593 0.2375
SRP008496 MGA 23269 RNAseq 0.4050 0.0249
SRP064894 MGA 23269 RNAseq -0.0723 0.7003
SRP133303 MGA 23269 RNAseq 0.1070 0.4050
SRP159526 MGA 23269 RNAseq 0.0025 0.9914
SRP193095 MGA 23269 RNAseq 0.1927 0.0039
SRP219564 MGA 23269 RNAseq -0.0982 0.7132
TCGA MGA 23269 RNAseq -0.0337 0.4690

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by MGA expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of MGA:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 MGA 23269 4 5 21
GSE20123 MGA 23269 4 5 21
GSE43470 MGA 23269 4 5 34
GSE46452 MGA 23269 3 7 49
GSE47630 MGA 23269 8 11 21
GSE54993 MGA 23269 4 6 60
GSE54994 MGA 23269 5 7 41
GSE60625 MGA 23269 4 0 7
GSE74703 MGA 23269 4 4 28
GSE74704 MGA 23269 3 3 14
TCGA MGA 23269 11 19 66

Total number of gains: 54; Total number of losses: 72; Total Number of normals: 362.  

 

Somatic mutations of MGA:

 

Generating mutation plots.

 

Highly correlated genes for MGA:

 

Showing top 20/94 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
MGALIPT10.754757303
MGABMPR20.73168303
MGASRPK10.702576403
MGAPOU2F10.681271303
MGAATF20.681194403
MGARBM230.673909303
MGADVL30.671708303
MGAPDE6D0.671024303
MGAMRPS220.665459403
MGAMRPL90.663442404
MGAKIN0.66156403
MGAERGIC20.658826403
MGAC1orf500.657105303
MGAMDN10.656005403
MGACNOT60.655205303
MGACDC1230.654859403
MGAGTF3C30.645589504
MGACELF10.645294504
MGAKDM1A0.634779403
MGAATG30.633842403

For details and further investigation, click here