| Full name: bromodomain PHD finger transcription factor | Alias Symbol: FAC1|NURF301 | ||
| Type: protein-coding gene | Cytoband: 17q24.2 | ||
| Entrez ID: 2186 | HGNC ID: HGNC:3581 | Ensembl Gene: ENSG00000171634 | OMIM ID: 601819 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of BPTF:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BPTF | 2186 | 207186_s_at | -0.1572 | 0.8005 | |
| GSE20347 | BPTF | 2186 | 207186_s_at | -0.2681 | 0.0491 | |
| GSE23400 | BPTF | 2186 | 207186_s_at | -0.3777 | 0.0039 | |
| GSE26886 | BPTF | 2186 | 207186_s_at | 0.5725 | 0.0149 | |
| GSE29001 | BPTF | 2186 | 207186_s_at | 0.1609 | 0.6337 | |
| GSE38129 | BPTF | 2186 | 207186_s_at | -0.1927 | 0.1132 | |
| GSE45670 | BPTF | 2186 | 207186_s_at | -0.0362 | 0.8677 | |
| GSE53622 | BPTF | 2186 | 124635 | -0.4644 | 0.0000 | |
| GSE53624 | BPTF | 2186 | 124635 | -0.5862 | 0.0000 | |
| GSE63941 | BPTF | 2186 | 232909_s_at | -0.1652 | 0.6399 | |
| GSE77861 | BPTF | 2186 | 232909_s_at | 0.3373 | 0.1094 | |
| GSE97050 | BPTF | 2186 | A_24_P104538 | -0.5027 | 0.1726 | |
| SRP007169 | BPTF | 2186 | RNAseq | 0.9202 | 0.0135 | |
| SRP008496 | BPTF | 2186 | RNAseq | 0.9680 | 0.0001 | |
| SRP064894 | BPTF | 2186 | RNAseq | -0.0783 | 0.6776 | |
| SRP133303 | BPTF | 2186 | RNAseq | 0.1686 | 0.3810 | |
| SRP159526 | BPTF | 2186 | RNAseq | 0.0089 | 0.9637 | |
| SRP193095 | BPTF | 2186 | RNAseq | -0.0195 | 0.8196 | |
| SRP219564 | BPTF | 2186 | RNAseq | -0.2574 | 0.2459 | |
| TCGA | BPTF | 2186 | RNAseq | -0.0394 | 0.3518 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by BPTF expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of BPTF:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BPTF | 2186 | 3 | 2 | 25 | |
| GSE20123 | BPTF | 2186 | 3 | 2 | 25 | |
| GSE43470 | BPTF | 2186 | 4 | 0 | 39 | |
| GSE46452 | BPTF | 2186 | 31 | 1 | 27 | |
| GSE47630 | BPTF | 2186 | 7 | 1 | 32 | |
| GSE54993 | BPTF | 2186 | 2 | 5 | 63 | |
| GSE54994 | BPTF | 2186 | 9 | 4 | 40 | |
| GSE60625 | BPTF | 2186 | 4 | 2 | 5 | |
| GSE74703 | BPTF | 2186 | 4 | 0 | 32 | |
| GSE74704 | BPTF | 2186 | 3 | 1 | 16 | |
| TCGA | BPTF | 2186 | 28 | 8 | 60 |
Total number of gains: 98; Total number of losses: 26; Total Number of normals: 364.
Somatic mutations of BPTF:
Generating mutation plots.
Highly correlated genes for BPTF:
Showing top 20/94 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BPTF | GOSR1 | 0.770661 | 3 | 0 | 3 |
| BPTF | SUPT20H | 0.724315 | 3 | 0 | 3 |
| BPTF | CEP95 | 0.696861 | 4 | 0 | 4 |
| BPTF | C8orf58 | 0.696357 | 3 | 0 | 3 |
| BPTF | MYZAP | 0.678336 | 3 | 0 | 3 |
| BPTF | RBBP6 | 0.673087 | 4 | 0 | 4 |
| BPTF | RAI2 | 0.658964 | 3 | 0 | 3 |
| BPTF | ZBTB4 | 0.657785 | 5 | 0 | 4 |
| BPTF | CEP63 | 0.653181 | 3 | 0 | 3 |
| BPTF | RBFOX3 | 0.647955 | 3 | 0 | 3 |
| BPTF | VMAC | 0.647743 | 3 | 0 | 3 |
| BPTF | CIR1 | 0.645616 | 3 | 0 | 3 |
| BPTF | FOXO1 | 0.643537 | 3 | 0 | 3 |
| BPTF | EBLN2 | 0.640285 | 3 | 0 | 3 |
| BPTF | ZNF133 | 0.640215 | 3 | 0 | 3 |
| BPTF | TACC1 | 0.631748 | 4 | 0 | 3 |
| BPTF | ITGB1BP2 | 0.621038 | 4 | 0 | 3 |
| BPTF | APOLD1 | 0.6197 | 4 | 0 | 3 |
| BPTF | RASSF3 | 0.612348 | 4 | 0 | 4 |
| BPTF | ZNF84 | 0.607125 | 4 | 0 | 3 |
For details and further investigation, click here
