ZNF133

 

Full name: zinc finger protein 133 Alias Symbol: pHZ-13|pHZ-66
Type: protein-coding gene Cytoband: 20p11.23
Entrez ID: 7692 HGNC ID: HGNC:12917 Ensembl Gene: ENSG00000125846 OMIM ID: 604075
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of ZNF133:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ZNF133 7692 37254_at 0.4128 0.3586
GSE20347 ZNF133 7692 37254_at 0.1755 0.2565
GSE23400 ZNF133 7692 37254_at 0.0990 0.0456
GSE26886 ZNF133 7692 37254_at 0.7903 0.0001
GSE29001 ZNF133 7692 37254_at 0.2716 0.1896
GSE38129 ZNF133 7692 37254_at 0.1798 0.0948
GSE45670 ZNF133 7692 37254_at 0.2361 0.1009
GSE53622 ZNF133 7692 51830 0.3741 0.0000
GSE53624 ZNF133 7692 51830 0.2954 0.0000
GSE63941 ZNF133 7692 37254_at 0.1026 0.8286
GSE77861 ZNF133 7692 216960_s_at 0.1305 0.3749
GSE97050 ZNF133 7692 A_33_P3394234 -0.1037 0.7791
SRP007169 ZNF133 7692 RNAseq 0.3030 0.5611
SRP008496 ZNF133 7692 RNAseq 1.0794 0.0147
SRP064894 ZNF133 7692 RNAseq 0.6119 0.0005
SRP133303 ZNF133 7692 RNAseq 0.2369 0.2687
SRP159526 ZNF133 7692 RNAseq 0.7182 0.0801
SRP193095 ZNF133 7692 RNAseq 0.2369 0.0646
SRP219564 ZNF133 7692 RNAseq 0.2536 0.4757
TCGA ZNF133 7692 RNAseq 0.0369 0.5622

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by ZNF133 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ZNF133:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ZNF133 7692 12 2 16
GSE20123 ZNF133 7692 12 2 16
GSE43470 ZNF133 7692 11 1 31
GSE46452 ZNF133 7692 27 1 31
GSE47630 ZNF133 7692 17 4 19
GSE54993 ZNF133 7692 0 15 55
GSE54994 ZNF133 7692 26 2 25
GSE60625 ZNF133 7692 0 0 11
GSE74703 ZNF133 7692 8 1 27
GSE74704 ZNF133 7692 7 2 11
TCGA ZNF133 7692 44 10 42

Total number of gains: 164; Total number of losses: 40; Total Number of normals: 284.  

 

Somatic mutations of ZNF133:

 

Generating mutation plots.

 

Highly correlated genes for ZNF133:

 

Showing top 20/223 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ZNF133IER5L0.779418303
ZNF133EFR3A0.77214303
ZNF133PNPLA70.753563303
ZNF133RAB440.751033303
ZNF133KRTAP10-120.707781303
ZNF133LRRC690.703194303
ZNF133RUVBL20.698882303
ZNF133RASL11B0.689027303
ZNF133MUCL10.683765303
ZNF133ZBTB460.682759303
ZNF133RANBP30.68033303
ZNF133SORCS30.679357303
ZNF133ZNF7630.676163303
ZNF133GTF2IRD20.669423403
ZNF133PLA2G150.665319504
ZNF133IFT430.663281403
ZNF133KCNQ1OT10.66246303
ZNF133SPATA170.659395303
ZNF133BAX0.657575303
ZNF133DPM30.656607303

For details and further investigation, click here