| Full name: corepressor interacting with RBPJ, 1 | Alias Symbol: CIR | ||
| Type: protein-coding gene | Cytoband: 2q31.1 | ||
| Entrez ID: 9541 | HGNC ID: HGNC:24217 | Ensembl Gene: ENSG00000138433 | OMIM ID: 605228 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
CIR1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04330 | Notch signaling pathway |
Expression of CIR1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CIR1 | 9541 | 209571_at | -0.1414 | 0.7213 | |
| GSE20347 | CIR1 | 9541 | 209571_at | 0.0006 | 0.9977 | |
| GSE23400 | CIR1 | 9541 | 209571_at | 0.0533 | 0.3403 | |
| GSE26886 | CIR1 | 9541 | 209571_at | 0.4118 | 0.1322 | |
| GSE29001 | CIR1 | 9541 | 209571_at | 0.1710 | 0.5711 | |
| GSE38129 | CIR1 | 9541 | 209571_at | 0.1770 | 0.1938 | |
| GSE45670 | CIR1 | 9541 | 209571_at | -0.0962 | 0.4245 | |
| GSE53622 | CIR1 | 9541 | 60598 | 0.0793 | 0.1421 | |
| GSE53624 | CIR1 | 9541 | 60598 | 0.1860 | 0.0000 | |
| GSE63941 | CIR1 | 9541 | 209571_at | -1.0093 | 0.0086 | |
| GSE77861 | CIR1 | 9541 | 209571_at | -0.0210 | 0.9223 | |
| GSE97050 | CIR1 | 9541 | A_23_P39814 | -0.2173 | 0.3051 | |
| SRP007169 | CIR1 | 9541 | RNAseq | -0.3038 | 0.3550 | |
| SRP008496 | CIR1 | 9541 | RNAseq | -0.2813 | 0.2320 | |
| SRP064894 | CIR1 | 9541 | RNAseq | 0.1810 | 0.3734 | |
| SRP133303 | CIR1 | 9541 | RNAseq | 0.0062 | 0.9586 | |
| SRP159526 | CIR1 | 9541 | RNAseq | -0.2124 | 0.4491 | |
| SRP193095 | CIR1 | 9541 | RNAseq | -0.3270 | 0.0266 | |
| SRP219564 | CIR1 | 9541 | RNAseq | -0.3569 | 0.1439 | |
| TCGA | CIR1 | 9541 | RNAseq | 0.0322 | 0.5637 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by CIR1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CIR1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CIR1 | 9541 | 10 | 0 | 20 | |
| GSE20123 | CIR1 | 9541 | 10 | 0 | 20 | |
| GSE43470 | CIR1 | 9541 | 6 | 1 | 36 | |
| GSE46452 | CIR1 | 9541 | 1 | 4 | 54 | |
| GSE47630 | CIR1 | 9541 | 5 | 3 | 32 | |
| GSE54993 | CIR1 | 9541 | 0 | 5 | 65 | |
| GSE54994 | CIR1 | 9541 | 11 | 4 | 38 | |
| GSE60625 | CIR1 | 9541 | 0 | 3 | 8 | |
| GSE74703 | CIR1 | 9541 | 5 | 1 | 30 | |
| GSE74704 | CIR1 | 9541 | 6 | 0 | 14 | |
| TCGA | CIR1 | 9541 | 29 | 5 | 62 |
Total number of gains: 83; Total number of losses: 26; Total Number of normals: 379.
Somatic mutations of CIR1:
Generating mutation plots.
Highly correlated genes for CIR1:
Showing top 20/203 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CIR1 | LYPLAL1 | 0.802216 | 3 | 0 | 3 |
| CIR1 | ANAPC4 | 0.769367 | 3 | 0 | 3 |
| CIR1 | ING2 | 0.759147 | 3 | 0 | 3 |
| CIR1 | PIN4 | 0.749242 | 3 | 0 | 3 |
| CIR1 | GOLGA3 | 0.736223 | 3 | 0 | 3 |
| CIR1 | RIMKLB | 0.736217 | 3 | 0 | 3 |
| CIR1 | PRPF4B | 0.735931 | 3 | 0 | 3 |
| CIR1 | EP300 | 0.735276 | 3 | 0 | 3 |
| CIR1 | MTX3 | 0.720774 | 3 | 0 | 3 |
| CIR1 | GGNBP2 | 0.713007 | 3 | 0 | 3 |
| CIR1 | METTL14 | 0.710453 | 3 | 0 | 3 |
| CIR1 | CHMP5 | 0.704418 | 3 | 0 | 3 |
| CIR1 | MBD5 | 0.703688 | 3 | 0 | 3 |
| CIR1 | TATDN1 | 0.701855 | 3 | 0 | 3 |
| CIR1 | C11orf58 | 0.691137 | 3 | 0 | 3 |
| CIR1 | SESTD1 | 0.689461 | 3 | 0 | 3 |
| CIR1 | MTRF1 | 0.685434 | 3 | 0 | 3 |
| CIR1 | AHCTF1 | 0.685001 | 3 | 0 | 3 |
| CIR1 | ARL8B | 0.680943 | 3 | 0 | 3 |
| CIR1 | ATG3 | 0.68039 | 3 | 0 | 3 |
For details and further investigation, click here
