| Full name: uncoupling protein 2 | Alias Symbol: SLC25A8 | ||
| Type: protein-coding gene | Cytoband: 11q13 | ||
| Entrez ID: 7351 | HGNC ID: HGNC:12518 | Ensembl Gene: ENSG00000175567 | OMIM ID: 601693 |
| Drug and gene relationship at DGIdb | |||
Expression of UCP2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | UCP2 | 7351 | 208998_at | 0.5749 | 0.5517 | |
| GSE20347 | UCP2 | 7351 | 208998_at | 0.8180 | 0.0029 | |
| GSE23400 | UCP2 | 7351 | 208998_at | 0.6490 | 0.0001 | |
| GSE26886 | UCP2 | 7351 | 208998_at | 1.3895 | 0.0081 | |
| GSE29001 | UCP2 | 7351 | 208998_at | 1.3788 | 0.0006 | |
| GSE38129 | UCP2 | 7351 | 208998_at | 0.6931 | 0.0846 | |
| GSE45670 | UCP2 | 7351 | 208998_at | 0.1230 | 0.7852 | |
| GSE53622 | UCP2 | 7351 | 60850 | 0.4699 | 0.0073 | |
| GSE53624 | UCP2 | 7351 | 60850 | 0.6060 | 0.0000 | |
| GSE63941 | UCP2 | 7351 | 208998_at | -0.6349 | 0.7211 | |
| GSE77861 | UCP2 | 7351 | 208998_at | 0.8084 | 0.0011 | |
| GSE97050 | UCP2 | 7351 | A_23_P47704 | 1.1282 | 0.0899 | |
| SRP007169 | UCP2 | 7351 | RNAseq | 2.8187 | 0.0000 | |
| SRP008496 | UCP2 | 7351 | RNAseq | 2.7611 | 0.0000 | |
| SRP064894 | UCP2 | 7351 | RNAseq | 1.0762 | 0.0007 | |
| SRP133303 | UCP2 | 7351 | RNAseq | -0.0102 | 0.9644 | |
| SRP159526 | UCP2 | 7351 | RNAseq | -0.1766 | 0.7726 | |
| SRP193095 | UCP2 | 7351 | RNAseq | 0.4447 | 0.1516 | |
| SRP219564 | UCP2 | 7351 | RNAseq | 1.0214 | 0.0066 | |
| TCGA | UCP2 | 7351 | RNAseq | 0.0024 | 0.9823 |
Upregulated datasets: 6; Downregulated datasets: 0.
Survival by UCP2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of UCP2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | UCP2 | 7351 | 5 | 9 | 16 | |
| GSE20123 | UCP2 | 7351 | 5 | 8 | 17 | |
| GSE43470 | UCP2 | 7351 | 6 | 4 | 33 | |
| GSE46452 | UCP2 | 7351 | 9 | 20 | 30 | |
| GSE47630 | UCP2 | 7351 | 6 | 14 | 20 | |
| GSE54993 | UCP2 | 7351 | 8 | 3 | 59 | |
| GSE54994 | UCP2 | 7351 | 8 | 15 | 30 | |
| GSE60625 | UCP2 | 7351 | 0 | 7 | 4 | |
| GSE74703 | UCP2 | 7351 | 5 | 3 | 28 | |
| GSE74704 | UCP2 | 7351 | 3 | 4 | 13 | |
| TCGA | UCP2 | 7351 | 26 | 28 | 42 |
Total number of gains: 81; Total number of losses: 115; Total Number of normals: 292.
Somatic mutations of UCP2:
Generating mutation plots.
Highly correlated genes for UCP2:
Showing top 20/1077 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| UCP2 | VMA21 | 0.808461 | 3 | 0 | 3 |
| UCP2 | LRRK1 | 0.807782 | 3 | 0 | 3 |
| UCP2 | ALKBH6 | 0.804213 | 3 | 0 | 3 |
| UCP2 | RNF217 | 0.792235 | 3 | 0 | 3 |
| UCP2 | RNMT | 0.781706 | 3 | 0 | 3 |
| UCP2 | QSOX2 | 0.780633 | 3 | 0 | 3 |
| UCP2 | BRAT1 | 0.770107 | 3 | 0 | 3 |
| UCP2 | WIZ | 0.761602 | 4 | 0 | 4 |
| UCP2 | PREX1 | 0.760573 | 4 | 0 | 3 |
| UCP2 | DGUOK | 0.754963 | 3 | 0 | 3 |
| UCP2 | WDR81 | 0.751042 | 4 | 0 | 4 |
| UCP2 | CHST3 | 0.743954 | 3 | 0 | 3 |
| UCP2 | GNA13 | 0.739549 | 3 | 0 | 3 |
| UCP2 | PLEKHA3 | 0.731502 | 3 | 0 | 3 |
| UCP2 | MCOLN3 | 0.727496 | 3 | 0 | 3 |
| UCP2 | DVL3 | 0.718931 | 4 | 0 | 3 |
| UCP2 | XXYLT1 | 0.715295 | 3 | 0 | 3 |
| UCP2 | PRDM15 | 0.708228 | 3 | 0 | 3 |
| UCP2 | TBL1XR1 | 0.707907 | 4 | 0 | 4 |
| UCP2 | KIAA0100 | 0.705148 | 3 | 0 | 3 |
For details and further investigation, click here
