BRCA2

 

Full name: BRCA2 DNA repair associated Alias Symbol: FAD|FAD1|BRCC2|XRCC11
Type: protein-coding gene Cytoband: 13q13.1
Entrez ID: 675 HGNC ID: HGNC:1101 Ensembl Gene: ENSG00000139618 OMIM ID: 600185
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 23/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

BRCA2 involved pathways:

KEGG pathway Description View
hsa03460Fanconi anemia pathway

 

Expression of BRCA2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 BRCA2 675 208368_s_at 0.9520 0.0655
GSE20347 BRCA2 675 208368_s_at 0.6843 0.0003
GSE23400 BRCA2 675 214727_at 0.2743 0.0000
GSE26886 BRCA2 675 208368_s_at 0.6878 0.0025
GSE29001 BRCA2 675 214727_at 0.2007 0.2079
GSE38129 BRCA2 675 208368_s_at 0.7225 0.0007
GSE45670 BRCA2 675 214727_at 1.0062 0.0004
GSE53622 BRCA2 675 68449 0.8487 0.0000
GSE53624 BRCA2 675 68449 1.1888 0.0000
GSE63941 BRCA2 675 208368_s_at 1.9517 0.0109
GSE77861 BRCA2 675 208368_s_at 0.6728 0.1001
GSE97050 BRCA2 675 A_23_P99452 0.2369 0.2763
SRP007169 BRCA2 675 RNAseq 1.5372 0.0013
SRP008496 BRCA2 675 RNAseq 1.6916 0.0000
SRP064894 BRCA2 675 RNAseq 1.0232 0.0051
SRP133303 BRCA2 675 RNAseq 1.1740 0.0001
SRP159526 BRCA2 675 RNAseq 0.8123 0.0115
SRP193095 BRCA2 675 RNAseq 0.6955 0.0000
SRP219564 BRCA2 675 RNAseq 0.6570 0.3433
TCGA BRCA2 675 RNAseq 0.8553 0.0000

Upregulated datasets: 7; Downregulated datasets: 0.  

 

Survival by BRCA2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of BRCA2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 BRCA2 675 1 15 14
GSE20123 BRCA2 675 1 14 15
GSE43470 BRCA2 675 2 13 28
GSE46452 BRCA2 675 0 33 26
GSE47630 BRCA2 675 2 27 11
GSE54993 BRCA2 675 12 2 56
GSE54994 BRCA2 675 2 15 36
GSE60625 BRCA2 675 0 3 8
GSE74703 BRCA2 675 2 10 24
GSE74704 BRCA2 675 0 12 8
TCGA BRCA2 675 8 37 51

Total number of gains: 30; Total number of losses: 181; Total Number of normals: 277.  

 

Somatic mutations of BRCA2:

 

Generating mutation plots.

 

Highly correlated genes for BRCA2:

 

Showing top 20/1457 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
BRCA2SLC36A40.762035404
BRCA2PHF60.741418303
BRCA2NAA250.735729303
BRCA2UCK20.735022303
BRCA2TTK0.73307312010
BRCA2KCNE30.724723303
BRCA2LRRC580.723115403
BRCA2LOXL40.721786303
BRCA2MTFR20.716447706
BRCA2KIF140.71614612010
BRCA2CENPL0.715236808
BRCA2DDIAS0.71387706
BRCA2BORA0.7120651009
BRCA2TYW50.709281303
BRCA2CCDC930.709199403
BRCA2PIGM0.70911303
BRCA2NUF20.708713908
BRCA2GEN10.701477707
BRCA2DNA20.70053311010
BRCA2KNTC10.6994711009

For details and further investigation, click here