| Full name: DNA replication helicase/nuclease 2 | Alias Symbol: KIAA0083 | ||
| Type: protein-coding gene | Cytoband: 10q21.3 | ||
| Entrez ID: 1763 | HGNC ID: HGNC:2939 | Ensembl Gene: ENSG00000138346 | OMIM ID: 601810 |
| Drug and gene relationship at DGIdb | |||
Expression of DNA2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DNA2 | 1763 | 213647_at | 1.2749 | 0.0384 | |
| GSE20347 | DNA2 | 1763 | 213647_at | 1.1167 | 0.0000 | |
| GSE23400 | DNA2 | 1763 | 213647_at | 0.5764 | 0.0000 | |
| GSE26886 | DNA2 | 1763 | 213647_at | 0.5399 | 0.0076 | |
| GSE29001 | DNA2 | 1763 | 213647_at | 1.2316 | 0.0001 | |
| GSE38129 | DNA2 | 1763 | 213647_at | 1.3435 | 0.0000 | |
| GSE45670 | DNA2 | 1763 | 213647_at | 0.8605 | 0.0000 | |
| GSE53622 | DNA2 | 1763 | 59109 | 1.3611 | 0.0000 | |
| GSE53624 | DNA2 | 1763 | 59109 | 1.7098 | 0.0000 | |
| GSE63941 | DNA2 | 1763 | 213647_at | 1.5579 | 0.0060 | |
| GSE77861 | DNA2 | 1763 | 213647_at | 0.5974 | 0.0274 | |
| GSE97050 | DNA2 | 1763 | A_33_P3833211 | 0.5681 | 0.1726 | |
| SRP007169 | DNA2 | 1763 | RNAseq | 1.0723 | 0.0360 | |
| SRP008496 | DNA2 | 1763 | RNAseq | 0.9695 | 0.0063 | |
| SRP064894 | DNA2 | 1763 | RNAseq | 0.9381 | 0.0008 | |
| SRP133303 | DNA2 | 1763 | RNAseq | 1.6180 | 0.0000 | |
| SRP159526 | DNA2 | 1763 | RNAseq | 1.3453 | 0.0000 | |
| SRP193095 | DNA2 | 1763 | RNAseq | 0.9292 | 0.0000 | |
| SRP219564 | DNA2 | 1763 | RNAseq | 1.0270 | 0.0313 | |
| TCGA | DNA2 | 1763 | RNAseq | 0.7736 | 0.0000 |
Upregulated datasets: 11; Downregulated datasets: 0.
Survival by DNA2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DNA2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DNA2 | 1763 | 3 | 5 | 22 | |
| GSE20123 | DNA2 | 1763 | 3 | 4 | 23 | |
| GSE43470 | DNA2 | 1763 | 1 | 8 | 34 | |
| GSE46452 | DNA2 | 1763 | 0 | 11 | 48 | |
| GSE47630 | DNA2 | 1763 | 2 | 14 | 24 | |
| GSE54993 | DNA2 | 1763 | 8 | 0 | 62 | |
| GSE54994 | DNA2 | 1763 | 2 | 12 | 39 | |
| GSE60625 | DNA2 | 1763 | 0 | 0 | 11 | |
| GSE74703 | DNA2 | 1763 | 1 | 5 | 30 | |
| GSE74704 | DNA2 | 1763 | 1 | 2 | 17 | |
| TCGA | DNA2 | 1763 | 10 | 22 | 64 |
Total number of gains: 31; Total number of losses: 83; Total Number of normals: 374.
Somatic mutations of DNA2:
Generating mutation plots.
Highly correlated genes for DNA2:
Showing top 20/1979 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DNA2 | MMS22L | 0.799487 | 3 | 0 | 3 |
| DNA2 | NEK2 | 0.786739 | 12 | 0 | 11 |
| DNA2 | DTL | 0.78107 | 13 | 0 | 12 |
| DNA2 | LRRC58 | 0.780914 | 4 | 0 | 4 |
| DNA2 | KIF14 | 0.779965 | 12 | 0 | 11 |
| DNA2 | CENPF | 0.773602 | 13 | 0 | 12 |
| DNA2 | NCAPG2 | 0.770042 | 11 | 0 | 11 |
| DNA2 | CDK1 | 0.768093 | 12 | 0 | 11 |
| DNA2 | TTK | 0.767745 | 12 | 0 | 11 |
| DNA2 | BLM | 0.764436 | 13 | 0 | 12 |
| DNA2 | SPAG5 | 0.763062 | 12 | 0 | 12 |
| DNA2 | DNAJC9 | 0.7626 | 10 | 0 | 9 |
| DNA2 | KIF18B | 0.761716 | 10 | 0 | 9 |
| DNA2 | CCNB2 | 0.761401 | 11 | 0 | 11 |
| DNA2 | FBXO5 | 0.75647 | 11 | 0 | 11 |
| DNA2 | NDC80 | 0.755654 | 12 | 0 | 11 |
| DNA2 | MCM10 | 0.755294 | 12 | 0 | 11 |
| DNA2 | FANCI | 0.754372 | 12 | 0 | 12 |
| DNA2 | NCAPH | 0.753809 | 9 | 0 | 9 |
| DNA2 | TOP2A | 0.752054 | 12 | 0 | 11 |
For details and further investigation, click here
