| Full name: SPC25 component of NDC80 kinetochore complex | Alias Symbol: MGC22228|AD024 | ||
| Type: protein-coding gene | Cytoband: 2q31.1 | ||
| Entrez ID: 57405 | HGNC ID: HGNC:24031 | Ensembl Gene: ENSG00000152253 | OMIM ID: 609395 |
| Drug and gene relationship at DGIdb | |||
Expression of SPC25:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPC25 | 57405 | 209891_at | 1.8284 | 0.0137 | |
| GSE20347 | SPC25 | 57405 | 209891_at | 1.3698 | 0.0000 | |
| GSE23400 | SPC25 | 57405 | 209891_at | 0.3602 | 0.0000 | |
| GSE26886 | SPC25 | 57405 | 209891_at | 1.4533 | 0.0006 | |
| GSE29001 | SPC25 | 57405 | 209891_at | 1.0533 | 0.0617 | |
| GSE38129 | SPC25 | 57405 | 209891_at | 1.9929 | 0.0000 | |
| GSE45670 | SPC25 | 57405 | 209891_at | 1.3924 | 0.0000 | |
| GSE53622 | SPC25 | 57405 | 16989 | 1.3112 | 0.0000 | |
| GSE53624 | SPC25 | 57405 | 16989 | 1.7874 | 0.0000 | |
| GSE63941 | SPC25 | 57405 | 209891_at | 3.5330 | 0.0000 | |
| GSE77861 | SPC25 | 57405 | 209891_at | 0.4828 | 0.1259 | |
| GSE97050 | SPC25 | 57405 | A_23_P51085 | 0.9319 | 0.1939 | |
| SRP007169 | SPC25 | 57405 | RNAseq | 1.6591 | 0.0020 | |
| SRP008496 | SPC25 | 57405 | RNAseq | 1.2545 | 0.0002 | |
| SRP064894 | SPC25 | 57405 | RNAseq | 1.4018 | 0.0000 | |
| SRP133303 | SPC25 | 57405 | RNAseq | 0.8590 | 0.0000 | |
| SRP159526 | SPC25 | 57405 | RNAseq | 1.2548 | 0.0002 | |
| SRP193095 | SPC25 | 57405 | RNAseq | 0.4871 | 0.0000 | |
| SRP219564 | SPC25 | 57405 | RNAseq | 1.0702 | 0.0837 | |
| TCGA | SPC25 | 57405 | RNAseq | 1.2728 | 0.0000 |
Upregulated datasets: 13; Downregulated datasets: 0.
Survival by SPC25 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPC25:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPC25 | 57405 | 6 | 0 | 24 | |
| GSE20123 | SPC25 | 57405 | 6 | 0 | 24 | |
| GSE43470 | SPC25 | 57405 | 5 | 1 | 37 | |
| GSE46452 | SPC25 | 57405 | 1 | 4 | 54 | |
| GSE47630 | SPC25 | 57405 | 5 | 3 | 32 | |
| GSE54993 | SPC25 | 57405 | 0 | 5 | 65 | |
| GSE54994 | SPC25 | 57405 | 11 | 2 | 40 | |
| GSE60625 | SPC25 | 57405 | 0 | 3 | 8 | |
| GSE74703 | SPC25 | 57405 | 4 | 1 | 31 | |
| GSE74704 | SPC25 | 57405 | 3 | 0 | 17 | |
| TCGA | SPC25 | 57405 | 24 | 10 | 62 |
Total number of gains: 65; Total number of losses: 29; Total Number of normals: 394.
Somatic mutations of SPC25:
Generating mutation plots.
Highly correlated genes for SPC25:
Showing top 20/1613 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPC25 | NUF2 | 0.847386 | 7 | 0 | 7 |
| SPC25 | CDK1 | 0.820628 | 11 | 0 | 11 |
| SPC25 | CCNB2 | 0.814857 | 10 | 0 | 9 |
| SPC25 | AURKB | 0.813228 | 12 | 0 | 12 |
| SPC25 | TTK | 0.811797 | 10 | 0 | 10 |
| SPC25 | TRIP13 | 0.808184 | 11 | 0 | 11 |
| SPC25 | DLGAP5 | 0.802318 | 13 | 0 | 13 |
| SPC25 | BUB1 | 0.793352 | 10 | 0 | 10 |
| SPC25 | KNSTRN | 0.791885 | 6 | 0 | 6 |
| SPC25 | MAD2L1 | 0.791003 | 12 | 0 | 11 |
| SPC25 | TPX2 | 0.786998 | 13 | 0 | 12 |
| SPC25 | KIF4A | 0.786591 | 13 | 0 | 12 |
| SPC25 | MCM10 | 0.781604 | 10 | 0 | 10 |
| SPC25 | DEPDC1B | 0.780967 | 8 | 0 | 8 |
| SPC25 | CENPF | 0.780327 | 12 | 0 | 12 |
| SPC25 | ECT2 | 0.778894 | 13 | 0 | 11 |
| SPC25 | HJURP | 0.7727 | 11 | 0 | 10 |
| SPC25 | CENPI | 0.768355 | 12 | 0 | 11 |
| SPC25 | GMNN | 0.767129 | 12 | 0 | 11 |
| SPC25 | MTERF3 | 0.766354 | 7 | 0 | 7 |
For details and further investigation, click here
