ECT2

 

Full name: epithelial cell transforming 2 Alias Symbol: ARHGEF31
Type: protein-coding gene Cytoband: 3q26.31
Entrez ID: 1894 HGNC ID: HGNC:3155 Ensembl Gene: ENSG00000114346 OMIM ID: 600586
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of ECT2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ECT2 1894 219787_s_at 1.9498 0.0132
GSE20347 ECT2 1894 219787_s_at 2.5337 0.0000
GSE23400 ECT2 1894 219787_s_at 2.3146 0.0000
GSE26886 ECT2 1894 219787_s_at 1.1950 0.0024
GSE29001 ECT2 1894 219787_s_at 2.3546 0.0001
GSE38129 ECT2 1894 219787_s_at 2.6888 0.0000
GSE45670 ECT2 1894 219787_s_at 1.8485 0.0000
GSE53622 ECT2 1894 57984 1.8340 0.0000
GSE53624 ECT2 1894 57984 2.1332 0.0000
GSE63941 ECT2 1894 219787_s_at 1.5904 0.0057
GSE77861 ECT2 1894 219787_s_at 1.7290 0.0042
GSE97050 ECT2 1894 A_23_P44684 0.7755 0.1235
SRP007169 ECT2 1894 RNAseq 2.9767 0.0000
SRP008496 ECT2 1894 RNAseq 2.9551 0.0000
SRP064894 ECT2 1894 RNAseq 1.9029 0.0000
SRP133303 ECT2 1894 RNAseq 2.2374 0.0000
SRP159526 ECT2 1894 RNAseq 1.9618 0.0000
SRP193095 ECT2 1894 RNAseq 1.6423 0.0000
SRP219564 ECT2 1894 RNAseq 1.5602 0.0166
TCGA ECT2 1894 RNAseq 0.7454 0.0000

Upregulated datasets: 18; Downregulated datasets: 0.  

 

Survival by ECT2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ECT2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ECT2 1894 24 0 6
GSE20123 ECT2 1894 24 0 6
GSE43470 ECT2 1894 23 0 20
GSE46452 ECT2 1894 19 1 39
GSE47630 ECT2 1894 27 2 11
GSE54993 ECT2 1894 1 15 54
GSE54994 ECT2 1894 41 0 12
GSE60625 ECT2 1894 0 6 5
GSE74703 ECT2 1894 19 0 17
GSE74704 ECT2 1894 16 0 4
TCGA ECT2 1894 79 0 17

Total number of gains: 273; Total number of losses: 24; Total Number of normals: 191.  

 

Somatic mutations of ECT2:

 

Generating mutation plots.

 

Highly correlated genes for ECT2:

 

Showing top 20/2005 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ECT2CDK10.86963312012
ECT2RAD51AP10.85884613013
ECT2ACTL6A0.84707612012
ECT2CKS1B0.84694112012
ECT2RFC40.84673913013
ECT2TRIP130.83428712012
ECT2CBX30.83369711011
ECT2TPX20.83208612012
ECT2KIF4A0.82778412011
ECT2AURKB0.82670612012
ECT2NEK20.82166213012
ECT2KIF140.82148513012
ECT2FOXM10.81770113012
ECT2MCM60.81719812012
ECT2GMPS0.8154711011
ECT2CEP550.81479213012
ECT2TIMELESS0.81453312012
ECT2CENPF0.81382113013
ECT2TOP2A0.81316113013
ECT2ATAD20.81251112011

For details and further investigation, click here