MAP2K2

 

Full name: mitogen-activated protein kinase kinase 2 Alias Symbol: MEK2
Type: protein-coding gene Cytoband: 19p13.3
Entrez ID: 5605 HGNC ID: HGNC:6842 Ensembl Gene: ENSG00000126934 OMIM ID: 601263
Drug and gene relationship at DGIdb

 

MAP2K2 involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04012ErbB signaling pathway
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
hsa04022cGMP-PKG signaling pathway
hsa04024cAMP signaling pathway
hsa04066HIF-1 signaling pathway
hsa04068FoxO signaling pathway
hsa04071Sphingolipid signaling pathway
hsa04072Phospholipase D signaling pathway
hsa04150mTOR signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04210Apoptosis
hsa04270Vascular smooth muscle contraction
hsa04370VEGF signaling pathway
hsa04540Gap junction
hsa04550Signaling pathways regulating pluripotency of stem cells
hsa04620Toll-like receptor signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa04660T cell receptor signaling pathway
hsa04662B cell receptor signaling pathway
hsa04664Fc epsilon RI signaling pathway
hsa04720Long-term potentiation
hsa04722Neurotrophin signaling pathway
hsa04730Long-term depression
hsa04810Regulation of actin cytoskeleton
hsa04910Insulin signaling pathway
hsa04912GnRH signaling pathway
hsa04915Estrogen signaling pathway
hsa04916Melanogenesis
hsa04917Prolactin signaling pathway
hsa04919Thyroid hormone signaling pathway
hsa04921Oxytocin signaling pathway
hsa05020Prion diseases
hsa05161Hepatitis B
hsa05164Influenza A
hsa05200Pathways in cancer
hsa05205Proteoglycans in cancer
hsa05211Renal cell carcinoma
hsa05213Endometrial cancer
hsa05214Glioma
hsa05215Prostate cancer
hsa05216Thyroid cancer
hsa05218Melanoma
hsa05219Bladder cancer
hsa05220Chronic myeloid leukemia
hsa05221Acute myeloid leukemia
hsa05223Non-small cell lung cancer
hsa05231Choline metabolism in cancer

 

Expression of MAP2K2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 MAP2K2 5605 202424_at 0.1397 0.7728
GSE20347 MAP2K2 5605 202424_at -0.2304 0.1434
GSE23400 MAP2K2 5605 202424_at -0.0618 0.3292
GSE26886 MAP2K2 5605 202424_at 0.4021 0.0943
GSE29001 MAP2K2 5605 202424_at -0.7149 0.0014
GSE38129 MAP2K2 5605 202424_at -0.1476 0.2952
GSE45670 MAP2K2 5605 202424_at 0.2897 0.0311
GSE53622 MAP2K2 5605 19620 -0.0939 0.1897
GSE53624 MAP2K2 5605 19620 0.0243 0.7294
GSE63941 MAP2K2 5605 202424_at 0.2212 0.5125
GSE77861 MAP2K2 5605 202424_at 0.0633 0.7589
GSE97050 MAP2K2 5605 A_23_P208835 0.3584 0.2665
SRP007169 MAP2K2 5605 RNAseq -1.3572 0.0000
SRP008496 MAP2K2 5605 RNAseq -1.5444 0.0000
SRP064894 MAP2K2 5605 RNAseq 0.1019 0.7298
SRP133303 MAP2K2 5605 RNAseq -0.3417 0.0266
SRP159526 MAP2K2 5605 RNAseq -0.2353 0.3286
SRP193095 MAP2K2 5605 RNAseq -0.4532 0.0001
SRP219564 MAP2K2 5605 RNAseq 0.0713 0.7821
TCGA MAP2K2 5605 RNAseq 0.0203 0.6599

Upregulated datasets: 0; Downregulated datasets: 2.  

 

Survival by MAP2K2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of MAP2K2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 MAP2K2 5605 5 3 22
GSE20123 MAP2K2 5605 4 2 24
GSE43470 MAP2K2 5605 1 9 33
GSE46452 MAP2K2 5605 47 1 11
GSE47630 MAP2K2 5605 5 7 28
GSE54993 MAP2K2 5605 16 3 51
GSE54994 MAP2K2 5605 6 16 31
GSE60625 MAP2K2 5605 9 0 2
GSE74703 MAP2K2 5605 1 6 29
GSE74704 MAP2K2 5605 1 2 17
TCGA MAP2K2 5605 11 18 67

Total number of gains: 106; Total number of losses: 67; Total Number of normals: 315.  

 

Somatic mutations of MAP2K2:

 

Generating mutation plots.

 

Highly correlated genes for MAP2K2:

 

Showing top 20/380 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
MAP2K2TRAPPC10.750243403
MAP2K2C21orf580.691352303
MAP2K2DERL10.687899303
MAP2K2PTPN230.686756404
MAP2K2EEFSEC0.685162404
MAP2K2OGFOD10.683585504
MAP2K2GTPBP100.677644303
MAP2K2GPR1080.673362403
MAP2K2OTUB10.667413303
MAP2K2RASAL30.664682303
MAP2K2NDUFAF30.663491403
MAP2K2PAK1IP10.659067303
MAP2K2COPE0.655702706
MAP2K2BANF10.653639403
MAP2K2PTOV10.653634707
MAP2K2PSMC40.646079604
MAP2K2KDM5A0.645302403
MAP2K2POU2F20.643442404
MAP2K2AKT1S10.642659706
MAP2K2SLIRP0.638032404

For details and further investigation, click here