| Full name: signal peptide peptidase like 2B | Alias Symbol: IMP4|PSL1|KIAA1532 | ||
| Type: protein-coding gene | Cytoband: 19p13.3 | ||
| Entrez ID: 56928 | HGNC ID: HGNC:30627 | Ensembl Gene: ENSG00000005206 | OMIM ID: 608239 |
| Drug and gene relationship at DGIdb | |||
Expression of SPPL2B:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPPL2B | 56928 | 225248_at | 0.3933 | 0.3817 | |
| GSE20347 | SPPL2B | 56928 | 210693_at | -0.0170 | 0.8279 | |
| GSE23400 | SPPL2B | 56928 | 215833_s_at | 0.0035 | 0.9496 | |
| GSE26886 | SPPL2B | 56928 | 225248_at | 0.1862 | 0.0685 | |
| GSE29001 | SPPL2B | 56928 | 215833_s_at | -0.0860 | 0.5748 | |
| GSE38129 | SPPL2B | 56928 | 210693_at | -0.0375 | 0.5563 | |
| GSE45670 | SPPL2B | 56928 | 225248_at | 0.1595 | 0.1130 | |
| GSE63941 | SPPL2B | 56928 | 225248_at | 0.1364 | 0.4171 | |
| GSE77861 | SPPL2B | 56928 | 225248_at | 0.0377 | 0.8259 | |
| GSE97050 | SPPL2B | 56928 | A_33_P3266520 | 0.3008 | 0.2206 | |
| SRP007169 | SPPL2B | 56928 | RNAseq | -0.2068 | 0.6791 | |
| SRP008496 | SPPL2B | 56928 | RNAseq | -0.1926 | 0.5056 | |
| SRP064894 | SPPL2B | 56928 | RNAseq | 0.5772 | 0.0086 | |
| SRP133303 | SPPL2B | 56928 | RNAseq | 0.1786 | 0.4027 | |
| SRP159526 | SPPL2B | 56928 | RNAseq | 0.4570 | 0.2272 | |
| SRP193095 | SPPL2B | 56928 | RNAseq | 0.1344 | 0.5766 | |
| SRP219564 | SPPL2B | 56928 | RNAseq | 0.3506 | 0.2992 | |
| TCGA | SPPL2B | 56928 | RNAseq | -0.1203 | 0.0146 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SPPL2B expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of SPPL2B:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPPL2B | 56928 | 4 | 4 | 22 | |
| GSE20123 | SPPL2B | 56928 | 4 | 4 | 22 | |
| GSE43470 | SPPL2B | 56928 | 1 | 10 | 32 | |
| GSE46452 | SPPL2B | 56928 | 47 | 1 | 11 | |
| GSE47630 | SPPL2B | 56928 | 5 | 7 | 28 | |
| GSE54993 | SPPL2B | 56928 | 16 | 3 | 51 | |
| GSE54994 | SPPL2B | 56928 | 8 | 15 | 30 | |
| GSE60625 | SPPL2B | 56928 | 9 | 0 | 2 | |
| GSE74703 | SPPL2B | 56928 | 1 | 7 | 28 | |
| GSE74704 | SPPL2B | 56928 | 2 | 3 | 15 | |
| TCGA | SPPL2B | 56928 | 6 | 25 | 65 |
Total number of gains: 103; Total number of losses: 79; Total Number of normals: 306.
Somatic mutations of SPPL2B:
Generating mutation plots.
Highly correlated genes for SPPL2B:
Showing top 20/224 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPPL2B | AAK1 | 0.692297 | 3 | 0 | 3 |
| SPPL2B | HOXD8 | 0.687538 | 3 | 0 | 3 |
| SPPL2B | DNAJC4 | 0.676677 | 4 | 0 | 3 |
| SPPL2B | C21orf58 | 0.675979 | 4 | 0 | 4 |
| SPPL2B | ABO | 0.648318 | 3 | 0 | 3 |
| SPPL2B | ARFGAP1 | 0.64387 | 4 | 0 | 3 |
| SPPL2B | HID1 | 0.637886 | 3 | 0 | 3 |
| SPPL2B | SIRPG | 0.636507 | 3 | 0 | 3 |
| SPPL2B | RHPN1 | 0.635032 | 4 | 0 | 3 |
| SPPL2B | LIN37 | 0.631564 | 4 | 0 | 3 |
| SPPL2B | ZP2 | 0.629279 | 3 | 0 | 3 |
| SPPL2B | ORAI2 | 0.628199 | 5 | 0 | 3 |
| SPPL2B | ATAD3B | 0.628125 | 4 | 0 | 3 |
| SPPL2B | GNL1 | 0.627312 | 4 | 0 | 4 |
| SPPL2B | CALR | 0.625275 | 4 | 0 | 3 |
| SPPL2B | TMEM86B | 0.624489 | 3 | 0 | 3 |
| SPPL2B | CCDC150 | 0.618822 | 4 | 0 | 4 |
| SPPL2B | CD3E | 0.618797 | 3 | 0 | 3 |
| SPPL2B | TAF6L | 0.618688 | 4 | 0 | 3 |
| SPPL2B | TCL1A | 0.61588 | 4 | 0 | 3 |
For details and further investigation, click here
