| Full name: glycoprotein Ib platelet subunit alpha | Alias Symbol: CD42b|GPIbalpha | ||
| Type: protein-coding gene | Cytoband: 17p13.2 | ||
| Entrez ID: 2811 | HGNC ID: HGNC:4439 | Ensembl Gene: ENSG00000185245 | OMIM ID: 606672 |
| Drug and gene relationship at DGIdb | |||
GP1BA involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04611 | Platelet activation |
Expression of GP1BA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GP1BA | 2811 | 207389_at | 0.1038 | 0.6368 | |
| GSE20347 | GP1BA | 2811 | 207389_at | 0.0934 | 0.3214 | |
| GSE23400 | GP1BA | 2811 | 207389_at | -0.1088 | 0.0018 | |
| GSE26886 | GP1BA | 2811 | 207389_at | 0.0702 | 0.5358 | |
| GSE29001 | GP1BA | 2811 | 207389_at | -0.0606 | 0.6255 | |
| GSE38129 | GP1BA | 2811 | 207389_at | -0.1000 | 0.4800 | |
| GSE45670 | GP1BA | 2811 | 207389_at | 0.1501 | 0.1459 | |
| GSE53622 | GP1BA | 2811 | 18306 | -0.0735 | 0.6360 | |
| GSE53624 | GP1BA | 2811 | 18306 | 0.2255 | 0.0118 | |
| GSE63941 | GP1BA | 2811 | 207389_at | -0.0231 | 0.8992 | |
| GSE77861 | GP1BA | 2811 | 207389_at | 0.0142 | 0.9327 | |
| GSE97050 | GP1BA | 2811 | A_24_P270829 | 0.2083 | 0.3382 | |
| SRP133303 | GP1BA | 2811 | RNAseq | -0.4991 | 0.0790 | |
| SRP159526 | GP1BA | 2811 | RNAseq | -0.5019 | 0.2425 | |
| SRP219564 | GP1BA | 2811 | RNAseq | 0.5308 | 0.4726 | |
| TCGA | GP1BA | 2811 | RNAseq | -0.1081 | 0.6738 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by GP1BA expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GP1BA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GP1BA | 2811 | 5 | 2 | 23 | |
| GSE20123 | GP1BA | 2811 | 5 | 3 | 22 | |
| GSE43470 | GP1BA | 2811 | 1 | 6 | 36 | |
| GSE46452 | GP1BA | 2811 | 34 | 1 | 24 | |
| GSE47630 | GP1BA | 2811 | 7 | 1 | 32 | |
| GSE54993 | GP1BA | 2811 | 4 | 3 | 63 | |
| GSE54994 | GP1BA | 2811 | 5 | 9 | 39 | |
| GSE60625 | GP1BA | 2811 | 4 | 0 | 7 | |
| GSE74703 | GP1BA | 2811 | 1 | 3 | 32 | |
| GSE74704 | GP1BA | 2811 | 3 | 1 | 16 | |
| TCGA | GP1BA | 2811 | 18 | 21 | 57 |
Total number of gains: 87; Total number of losses: 50; Total Number of normals: 351.
Somatic mutations of GP1BA:
Generating mutation plots.
Highly correlated genes for GP1BA:
Showing top 20/662 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GP1BA | OR10H3 | 0.747663 | 4 | 0 | 4 |
| GP1BA | IFNA17 | 0.729181 | 4 | 0 | 4 |
| GP1BA | UBE2D4 | 0.719242 | 3 | 0 | 3 |
| GP1BA | CYSLTR2 | 0.714427 | 4 | 0 | 4 |
| GP1BA | C8A | 0.713798 | 4 | 0 | 4 |
| GP1BA | FAM3A | 0.710979 | 3 | 0 | 3 |
| GP1BA | PTPRJ | 0.707199 | 4 | 0 | 4 |
| GP1BA | ZMAT4 | 0.706783 | 3 | 0 | 3 |
| GP1BA | CRISP1 | 0.706776 | 4 | 0 | 4 |
| GP1BA | DAB1 | 0.703148 | 5 | 0 | 5 |
| GP1BA | GRINA | 0.699367 | 3 | 0 | 3 |
| GP1BA | TNKS1BP1 | 0.696798 | 3 | 0 | 3 |
| GP1BA | NEUROD2 | 0.695963 | 4 | 0 | 4 |
| GP1BA | MAN1B1 | 0.695227 | 3 | 0 | 3 |
| GP1BA | ODF1 | 0.695019 | 5 | 0 | 4 |
| GP1BA | KIF17 | 0.694253 | 4 | 0 | 4 |
| GP1BA | TACR3 | 0.68816 | 4 | 0 | 4 |
| GP1BA | GPA33 | 0.678372 | 6 | 0 | 5 |
| GP1BA | PRLR | 0.677108 | 4 | 0 | 4 |
| GP1BA | KCNA1 | 0.676449 | 5 | 0 | 5 |
For details and further investigation, click here
