| Full name: cholecystokinin A receptor | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 4p15.2 | ||
| Entrez ID: 886 | HGNC ID: HGNC:1570 | Ensembl Gene: ENSG00000163394 | OMIM ID: 118444 |
| Drug and gene relationship at DGIdb | |||
CCKAR involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04020 | Calcium signaling pathway | |
| hsa04911 | Insulin secretion | |
| hsa04972 | Pancreatic secretion |
Expression of CCKAR:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CCKAR | 886 | 211173_at | -0.0998 | 0.7584 | |
| GSE20347 | CCKAR | 886 | 211173_at | -0.0458 | 0.6125 | |
| GSE23400 | CCKAR | 886 | 211173_at | -0.0417 | 0.3252 | |
| GSE26886 | CCKAR | 886 | 211173_at | -0.2832 | 0.0087 | |
| GSE29001 | CCKAR | 886 | 211173_at | -0.2608 | 0.2094 | |
| GSE38129 | CCKAR | 886 | 211173_at | -0.2471 | 0.0743 | |
| GSE45670 | CCKAR | 886 | 211173_at | 0.1167 | 0.2328 | |
| GSE63941 | CCKAR | 886 | 211173_at | 0.2720 | 0.0696 | |
| GSE77861 | CCKAR | 886 | 211174_s_at | -0.0157 | 0.9164 | |
| TCGA | CCKAR | 886 | RNAseq | -5.1696 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by CCKAR expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of CCKAR:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CCKAR | 886 | 0 | 18 | 12 | |
| GSE20123 | CCKAR | 886 | 0 | 16 | 14 | |
| GSE43470 | CCKAR | 886 | 0 | 14 | 29 | |
| GSE46452 | CCKAR | 886 | 1 | 36 | 22 | |
| GSE47630 | CCKAR | 886 | 1 | 19 | 20 | |
| GSE54993 | CCKAR | 886 | 9 | 0 | 61 | |
| GSE54994 | CCKAR | 886 | 5 | 11 | 37 | |
| GSE60625 | CCKAR | 886 | 0 | 0 | 11 | |
| GSE74703 | CCKAR | 886 | 0 | 12 | 24 | |
| GSE74704 | CCKAR | 886 | 0 | 10 | 10 | |
| TCGA | CCKAR | 886 | 11 | 47 | 38 |
Total number of gains: 27; Total number of losses: 183; Total Number of normals: 278.
Somatic mutations of CCKAR:
Generating mutation plots.
Highly correlated genes for CCKAR:
Showing top 20/435 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CCKAR | KCNMB2 | 0.716287 | 4 | 0 | 4 |
| CCKAR | CA8 | 0.693061 | 4 | 0 | 4 |
| CCKAR | PSG5 | 0.670532 | 3 | 0 | 3 |
| CCKAR | PLA2G12B | 0.665147 | 3 | 0 | 3 |
| CCKAR | PTCRA | 0.664794 | 5 | 0 | 5 |
| CCKAR | EPS8L3 | 0.662975 | 5 | 0 | 5 |
| CCKAR | FBP2 | 0.662562 | 5 | 0 | 4 |
| CCKAR | C11orf16 | 0.66235 | 6 | 0 | 6 |
| CCKAR | PNLIPRP1 | 0.662168 | 6 | 0 | 6 |
| CCKAR | SIK1 | 0.654405 | 3 | 0 | 3 |
| CCKAR | NOS1 | 0.649837 | 5 | 0 | 4 |
| CCKAR | KCNE2 | 0.648953 | 4 | 0 | 4 |
| CCKAR | NEUROD1 | 0.646096 | 4 | 0 | 4 |
| CCKAR | ALPL | 0.643933 | 3 | 0 | 3 |
| CCKAR | NNAT | 0.642146 | 5 | 0 | 4 |
| CCKAR | MAML3 | 0.638204 | 4 | 0 | 3 |
| CCKAR | ADAMTS7 | 0.634889 | 4 | 0 | 4 |
| CCKAR | USHBP1 | 0.631917 | 3 | 0 | 3 |
| CCKAR | SLC2A5 | 0.62876 | 3 | 0 | 3 |
| CCKAR | ORM1 | 0.628422 | 3 | 0 | 3 |
For details and further investigation, click here
