| Full name: calcium voltage-gated channel subunit alpha1 E | Alias Symbol: Cav2.3|BII|CACH6 | ||
| Type: protein-coding gene | Cytoband: 1q25.3 | ||
| Entrez ID: 777 | HGNC ID: HGNC:1392 | Ensembl Gene: ENSG00000198216 | OMIM ID: 601013 |
| Drug and gene relationship at DGIdb | |||
CACNA1E involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04010 | MAPK signaling pathway | |
| hsa04020 | Calcium signaling pathway | |
| hsa04930 | Type II diabetes mellitus |
Expression of CACNA1E:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CACNA1E | 777 | 236013_at | 0.1193 | 0.5831 | |
| GSE20347 | CACNA1E | 777 | 208432_s_at | -0.0090 | 0.8911 | |
| GSE23400 | CACNA1E | 777 | 208432_s_at | -0.1138 | 0.0000 | |
| GSE26886 | CACNA1E | 777 | 208432_s_at | 0.2174 | 0.0780 | |
| GSE29001 | CACNA1E | 777 | 208432_s_at | -0.1306 | 0.2597 | |
| GSE38129 | CACNA1E | 777 | 208432_s_at | -0.0710 | 0.3555 | |
| GSE45670 | CACNA1E | 777 | 208432_s_at | -0.2041 | 0.0249 | |
| GSE53622 | CACNA1E | 777 | 96219 | -0.0844 | 0.5243 | |
| GSE53624 | CACNA1E | 777 | 96219 | 0.3449 | 0.0097 | |
| GSE63941 | CACNA1E | 777 | 240650_at | -0.0161 | 0.9342 | |
| GSE77861 | CACNA1E | 777 | 236013_at | -0.0949 | 0.4498 | |
| SRP133303 | CACNA1E | 777 | RNAseq | -0.1003 | 0.8236 | |
| TCGA | CACNA1E | 777 | RNAseq | -0.4511 | 0.3752 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CACNA1E expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CACNA1E:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CACNA1E | 777 | 12 | 0 | 18 | |
| GSE20123 | CACNA1E | 777 | 12 | 0 | 18 | |
| GSE43470 | CACNA1E | 777 | 7 | 1 | 35 | |
| GSE46452 | CACNA1E | 777 | 3 | 1 | 55 | |
| GSE47630 | CACNA1E | 777 | 14 | 0 | 26 | |
| GSE54993 | CACNA1E | 777 | 0 | 6 | 64 | |
| GSE54994 | CACNA1E | 777 | 15 | 0 | 38 | |
| GSE60625 | CACNA1E | 777 | 0 | 0 | 11 | |
| GSE74703 | CACNA1E | 777 | 7 | 1 | 28 | |
| GSE74704 | CACNA1E | 777 | 5 | 0 | 15 | |
| TCGA | CACNA1E | 777 | 40 | 3 | 53 |
Total number of gains: 115; Total number of losses: 12; Total Number of normals: 361.
Somatic mutations of CACNA1E:
Generating mutation plots.
Highly correlated genes for CACNA1E:
Showing top 20/571 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CACNA1E | MYOD1 | 0.711972 | 3 | 0 | 3 |
| CACNA1E | ART1 | 0.700279 | 3 | 0 | 3 |
| CACNA1E | GABRB2 | 0.679228 | 3 | 0 | 3 |
| CACNA1E | CSRP3 | 0.67762 | 3 | 0 | 3 |
| CACNA1E | TP73 | 0.662872 | 4 | 0 | 4 |
| CACNA1E | CCL25 | 0.660819 | 5 | 0 | 5 |
| CACNA1E | DLX2 | 0.655239 | 5 | 0 | 5 |
| CACNA1E | HTR4 | 0.646505 | 5 | 0 | 4 |
| CACNA1E | ASIC4 | 0.646467 | 5 | 0 | 5 |
| CACNA1E | GDF2 | 0.646268 | 6 | 0 | 6 |
| CACNA1E | SLC22A13 | 0.64566 | 4 | 0 | 3 |
| CACNA1E | GDF5 | 0.641997 | 4 | 0 | 4 |
| CACNA1E | KCNMB2 | 0.636092 | 4 | 0 | 3 |
| CACNA1E | TCL6 | 0.635698 | 4 | 0 | 3 |
| CACNA1E | TRPM3 | 0.631928 | 5 | 0 | 3 |
| CACNA1E | FSHR | 0.630003 | 4 | 0 | 3 |
| CACNA1E | IGH | 0.628422 | 6 | 0 | 5 |
| CACNA1E | GP2 | 0.628046 | 5 | 0 | 4 |
| CACNA1E | C2CD4B | 0.627193 | 3 | 0 | 3 |
| CACNA1E | CD80 | 0.62701 | 4 | 0 | 4 |
For details and further investigation, click here
