FN1

 

Full name: fibronectin 1 Alias Symbol: MSF|CIG|LETS|GFND2|FINC
Type: protein-coding gene Cytoband: 2q35
Entrez ID: 2335 HGNC ID: HGNC:3778 Ensembl Gene: ENSG00000115414 OMIM ID: 135600
Drug and gene relationship at DGIdb

 

FN1 involved pathways:

KEGG pathway Description View
hsa04151PI3K-Akt signaling pathway
hsa04510Focal adhesion
hsa05100Bacterial invasion of epithelial cells
hsa05200Pathways in cancer
hsa05205Proteoglycans in cancer
hsa05222Small cell lung cancer

 

Expression of FN1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 FN1 2335 211719_x_at -0.0160 0.9928
GSE20347 FN1 2335 211719_x_at 2.1614 0.0009
GSE23400 FN1 2335 210495_x_at 1.0571 0.0000
GSE26886 FN1 2335 210495_x_at 4.4915 0.0000
GSE29001 FN1 2335 211719_x_at 1.3486 0.0310
GSE38129 FN1 2335 211719_x_at 1.7197 0.0001
GSE45670 FN1 2335 211719_x_at -1.7608 0.0754
GSE53622 FN1 2335 12618 2.0334 0.0000
GSE53624 FN1 2335 12618 2.1032 0.0000
GSE63941 FN1 2335 210495_x_at -6.5212 0.0006
GSE77861 FN1 2335 210495_x_at 2.6852 0.0384
GSE97050 FN1 2335 A_24_P334130 1.7143 0.1027
SRP007169 FN1 2335 RNAseq 7.3721 0.0000
SRP008496 FN1 2335 RNAseq 8.0348 0.0000
SRP064894 FN1 2335 RNAseq 2.1248 0.0000
SRP133303 FN1 2335 RNAseq 2.2529 0.0000
SRP159526 FN1 2335 RNAseq 0.5267 0.3163
SRP193095 FN1 2335 RNAseq 4.4497 0.0000
SRP219564 FN1 2335 RNAseq 0.5594 0.5068
TCGA FN1 2335 RNAseq 0.0982 0.3672

Upregulated datasets: 13; Downregulated datasets: 1.  

 

Survival by FN1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of FN1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 FN1 2335 1 13 16
GSE20123 FN1 2335 1 13 16
GSE43470 FN1 2335 0 7 36
GSE46452 FN1 2335 0 5 54
GSE47630 FN1 2335 4 5 31
GSE54993 FN1 2335 0 3 67
GSE54994 FN1 2335 8 9 36
GSE60625 FN1 2335 0 3 8
GSE74703 FN1 2335 0 6 30
GSE74704 FN1 2335 1 7 12
TCGA FN1 2335 12 27 57

Total number of gains: 27; Total number of losses: 98; Total Number of normals: 363.  

 

Somatic mutations of FN1:

 

Generating mutation plots.

 

Highly correlated genes for FN1:

 

Showing top 20/898 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
FN1COL6A30.85769512012
FN1SPARC0.840912012
FN1COL12A10.837008808
FN1VCAN0.8366112012
FN1FBN10.8355651009
FN1COL3A10.83488812012
FN1COL6A20.82428911011
FN1POSTN0.82059112012
FN1COL1A20.81851112012
FN1DNM3OS0.805345303
FN1SULF10.80226412012
FN1COL6A10.80200412011
FN1AEBP10.79808512012
FN1COL8A10.793257908
FN1LGALS10.78551912012
FN1LUM0.78457212012
FN1GLIPR20.776737404
FN1CTSK0.7755912012
FN1VIM0.76885412012
FN1FERMT20.768441909

For details and further investigation, click here