| Full name: TOR signaling pathway regulator | Alias Symbol: MGC3794|dJ69E11.3|TIP41|TIPRL1 | ||
| Type: protein-coding gene | Cytoband: 1q24.2 | ||
| Entrez ID: 261726 | HGNC ID: HGNC:30231 | Ensembl Gene: ENSG00000143155 | OMIM ID: 611807 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of TIPRL:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TIPRL | 261726 | 214773_x_at | 0.1861 | 0.7598 | |
| GSE20347 | TIPRL | 261726 | 214773_x_at | 0.0834 | 0.7554 | |
| GSE23400 | TIPRL | 261726 | 214773_x_at | 0.0283 | 0.7629 | |
| GSE26886 | TIPRL | 261726 | 214773_x_at | 0.0615 | 0.7912 | |
| GSE29001 | TIPRL | 261726 | 214773_x_at | -0.0779 | 0.8524 | |
| GSE38129 | TIPRL | 261726 | 214773_x_at | 0.0800 | 0.6522 | |
| GSE45670 | TIPRL | 261726 | 228619_x_at | -0.2092 | 0.2821 | |
| GSE53622 | TIPRL | 261726 | 91506 | 0.1553 | 0.0008 | |
| GSE53624 | TIPRL | 261726 | 91506 | 0.2946 | 0.0000 | |
| GSE63941 | TIPRL | 261726 | 1554351_a_at | 0.5927 | 0.0481 | |
| GSE77861 | TIPRL | 261726 | 214773_x_at | 0.6110 | 0.0830 | |
| GSE97050 | TIPRL | 261726 | A_23_P327426 | 0.1885 | 0.5594 | |
| SRP007169 | TIPRL | 261726 | RNAseq | -1.1011 | 0.0015 | |
| SRP008496 | TIPRL | 261726 | RNAseq | -0.8077 | 0.0014 | |
| SRP064894 | TIPRL | 261726 | RNAseq | -0.1482 | 0.2561 | |
| SRP133303 | TIPRL | 261726 | RNAseq | 0.1256 | 0.4184 | |
| SRP159526 | TIPRL | 261726 | RNAseq | 0.1953 | 0.5022 | |
| SRP193095 | TIPRL | 261726 | RNAseq | -0.1355 | 0.2052 | |
| SRP219564 | TIPRL | 261726 | RNAseq | 0.0306 | 0.9491 | |
| TCGA | TIPRL | 261726 | RNAseq | 0.1660 | 0.0011 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by TIPRL expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TIPRL:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TIPRL | 261726 | 11 | 1 | 18 | |
| GSE20123 | TIPRL | 261726 | 11 | 1 | 18 | |
| GSE43470 | TIPRL | 261726 | 7 | 2 | 34 | |
| GSE46452 | TIPRL | 261726 | 3 | 1 | 55 | |
| GSE47630 | TIPRL | 261726 | 14 | 0 | 26 | |
| GSE54993 | TIPRL | 261726 | 0 | 6 | 64 | |
| GSE54994 | TIPRL | 261726 | 16 | 0 | 37 | |
| GSE60625 | TIPRL | 261726 | 0 | 0 | 11 | |
| GSE74703 | TIPRL | 261726 | 7 | 2 | 27 | |
| GSE74704 | TIPRL | 261726 | 5 | 0 | 15 | |
| TCGA | TIPRL | 261726 | 43 | 3 | 50 |
Total number of gains: 117; Total number of losses: 16; Total Number of normals: 355.
Somatic mutations of TIPRL:
Generating mutation plots.
Highly correlated genes for TIPRL:
Showing top 20/255 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TIPRL | ZNF814 | 0.876178 | 3 | 0 | 3 |
| TIPRL | SFSWAP | 0.854189 | 3 | 0 | 3 |
| TIPRL | IRF2BP2 | 0.802483 | 3 | 0 | 3 |
| TIPRL | CBX5 | 0.788277 | 3 | 0 | 3 |
| TIPRL | RP9 | 0.787841 | 3 | 0 | 3 |
| TIPRL | CAMKK2 | 0.785685 | 3 | 0 | 3 |
| TIPRL | TNRC18 | 0.754717 | 3 | 0 | 3 |
| TIPRL | PTPN4 | 0.748043 | 3 | 0 | 3 |
| TIPRL | NOM1 | 0.733121 | 3 | 0 | 3 |
| TIPRL | ZNF397 | 0.728551 | 3 | 0 | 3 |
| TIPRL | ZNF567 | 0.725586 | 4 | 0 | 4 |
| TIPRL | U2AF2 | 0.724065 | 3 | 0 | 3 |
| TIPRL | MATR3 | 0.719762 | 3 | 0 | 3 |
| TIPRL | MED29 | 0.716025 | 3 | 0 | 3 |
| TIPRL | MRPS6 | 0.715549 | 3 | 0 | 3 |
| TIPRL | GATAD2B | 0.715023 | 4 | 0 | 4 |
| TIPRL | WWP1 | 0.703837 | 4 | 0 | 3 |
| TIPRL | TRMT2B | 0.703604 | 3 | 0 | 3 |
| TIPRL | C6orf141 | 0.698895 | 3 | 0 | 3 |
| TIPRL | HMGB1 | 0.697286 | 4 | 0 | 3 |
For details and further investigation, click here
