| Full name: carbonyl reductase 4 | Alias Symbol: FLJ14431|SDR45C1 | ||
| Type: protein-coding gene | Cytoband: 4q32.3 | ||
| Entrez ID: 84869 | HGNC ID: HGNC:25891 | Ensembl Gene: ENSG00000145439 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of CBR4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CBR4 | 84869 | 213626_at | -0.6674 | 0.2864 | |
| GSE20347 | CBR4 | 84869 | 213626_at | -0.8983 | 0.0001 | |
| GSE23400 | CBR4 | 84869 | 213626_at | -0.2837 | 0.0006 | |
| GSE26886 | CBR4 | 84869 | 244052_at | -0.2566 | 0.3078 | |
| GSE29001 | CBR4 | 84869 | 213626_at | -0.1787 | 0.4510 | |
| GSE38129 | CBR4 | 84869 | 213626_at | -0.7144 | 0.0001 | |
| GSE45670 | CBR4 | 84869 | 213626_at | -0.5715 | 0.0163 | |
| GSE53622 | CBR4 | 84869 | 57746 | -0.6897 | 0.0000 | |
| GSE53624 | CBR4 | 84869 | 57746 | -0.7103 | 0.0000 | |
| GSE63941 | CBR4 | 84869 | 213626_at | -0.7694 | 0.1944 | |
| GSE77861 | CBR4 | 84869 | 244052_at | -0.1463 | 0.4156 | |
| GSE97050 | CBR4 | 84869 | A_33_P3234804 | -0.5135 | 0.2049 | |
| SRP007169 | CBR4 | 84869 | RNAseq | -0.3756 | 0.5528 | |
| SRP064894 | CBR4 | 84869 | RNAseq | -0.4215 | 0.0230 | |
| SRP133303 | CBR4 | 84869 | RNAseq | -0.0795 | 0.6422 | |
| SRP159526 | CBR4 | 84869 | RNAseq | -0.5376 | 0.1853 | |
| SRP193095 | CBR4 | 84869 | RNAseq | -0.6540 | 0.0000 | |
| SRP219564 | CBR4 | 84869 | RNAseq | -0.7487 | 0.0248 | |
| TCGA | CBR4 | 84869 | RNAseq | -0.2086 | 0.0002 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CBR4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CBR4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CBR4 | 84869 | 2 | 12 | 16 | |
| GSE20123 | CBR4 | 84869 | 2 | 12 | 16 | |
| GSE43470 | CBR4 | 84869 | 0 | 13 | 30 | |
| GSE46452 | CBR4 | 84869 | 1 | 36 | 22 | |
| GSE47630 | CBR4 | 84869 | 0 | 22 | 18 | |
| GSE54993 | CBR4 | 84869 | 10 | 0 | 60 | |
| GSE54994 | CBR4 | 84869 | 1 | 13 | 39 | |
| GSE60625 | CBR4 | 84869 | 0 | 0 | 11 | |
| GSE74703 | CBR4 | 84869 | 0 | 11 | 25 | |
| GSE74704 | CBR4 | 84869 | 1 | 6 | 13 | |
| TCGA | CBR4 | 84869 | 12 | 33 | 51 |
Total number of gains: 29; Total number of losses: 158; Total Number of normals: 301.
Somatic mutations of CBR4:
Generating mutation plots.
Highly correlated genes for CBR4:
Showing top 20/812 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CBR4 | PSMD7 | 0.814355 | 3 | 0 | 3 |
| CBR4 | UQCRC2 | 0.794302 | 3 | 0 | 3 |
| CBR4 | HAGH | 0.773151 | 3 | 0 | 3 |
| CBR4 | ZNF564 | 0.75063 | 3 | 0 | 3 |
| CBR4 | FAHD1 | 0.740222 | 3 | 0 | 3 |
| CBR4 | PTGER3 | 0.736633 | 3 | 0 | 3 |
| CBR4 | PREX2 | 0.714393 | 4 | 0 | 4 |
| CBR4 | EEPD1 | 0.711717 | 3 | 0 | 3 |
| CBR4 | PAQR7 | 0.701792 | 3 | 0 | 3 |
| CBR4 | CYP4V2 | 0.699525 | 3 | 0 | 3 |
| CBR4 | IRAK2 | 0.699269 | 3 | 0 | 3 |
| CBR4 | CYP2U1 | 0.69822 | 3 | 0 | 3 |
| CBR4 | TTC39B | 0.697948 | 3 | 0 | 3 |
| CBR4 | ABCG2 | 0.697064 | 4 | 0 | 3 |
| CBR4 | SDHB | 0.691289 | 3 | 0 | 3 |
| CBR4 | PNPLA8 | 0.691145 | 3 | 0 | 3 |
| CBR4 | PTPRB | 0.686565 | 4 | 0 | 3 |
| CBR4 | RPL41 | 0.682768 | 3 | 0 | 3 |
| CBR4 | EPC1 | 0.681253 | 4 | 0 | 4 |
| CBR4 | ZACN | 0.680791 | 3 | 0 | 3 |
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