| Full name: succinate dehydrogenase complex iron sulfur subunit B | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1p36.13 | ||
| Entrez ID: 6390 | HGNC ID: HGNC:10681 | Ensembl Gene: ENSG00000117118 | OMIM ID: 185470 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of SDHB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SDHB | 6390 | 202675_at | 0.0183 | 0.9755 | |
| GSE20347 | SDHB | 6390 | 202675_at | -0.0496 | 0.8266 | |
| GSE23400 | SDHB | 6390 | 202675_at | 0.0942 | 0.1585 | |
| GSE26886 | SDHB | 6390 | 202675_at | 0.0793 | 0.8174 | |
| GSE29001 | SDHB | 6390 | 202675_at | 0.1055 | 0.8749 | |
| GSE38129 | SDHB | 6390 | 202675_at | 0.0658 | 0.6959 | |
| GSE45670 | SDHB | 6390 | 202675_at | 0.0409 | 0.7641 | |
| GSE53622 | SDHB | 6390 | 121213 | 0.0454 | 0.5437 | |
| GSE53624 | SDHB | 6390 | 121213 | 0.0663 | 0.4537 | |
| GSE63941 | SDHB | 6390 | 202675_at | 0.6394 | 0.0373 | |
| GSE77861 | SDHB | 6390 | 202675_at | -0.3761 | 0.2066 | |
| GSE97050 | SDHB | 6390 | A_23_P149649 | 0.0890 | 0.7514 | |
| SRP007169 | SDHB | 6390 | RNAseq | -0.6205 | 0.1091 | |
| SRP008496 | SDHB | 6390 | RNAseq | -0.5070 | 0.0187 | |
| SRP064894 | SDHB | 6390 | RNAseq | 0.1336 | 0.4042 | |
| SRP133303 | SDHB | 6390 | RNAseq | 0.2283 | 0.0928 | |
| SRP159526 | SDHB | 6390 | RNAseq | 0.1332 | 0.6206 | |
| SRP193095 | SDHB | 6390 | RNAseq | -0.3365 | 0.0101 | |
| SRP219564 | SDHB | 6390 | RNAseq | -0.2654 | 0.2622 | |
| TCGA | SDHB | 6390 | RNAseq | -0.0659 | 0.1602 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SDHB expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SDHB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SDHB | 6390 | 0 | 5 | 25 | |
| GSE20123 | SDHB | 6390 | 0 | 4 | 26 | |
| GSE43470 | SDHB | 6390 | 0 | 8 | 35 | |
| GSE46452 | SDHB | 6390 | 5 | 1 | 53 | |
| GSE47630 | SDHB | 6390 | 8 | 3 | 29 | |
| GSE54993 | SDHB | 6390 | 3 | 1 | 66 | |
| GSE54994 | SDHB | 6390 | 10 | 4 | 39 | |
| GSE60625 | SDHB | 6390 | 0 | 0 | 11 | |
| GSE74703 | SDHB | 6390 | 0 | 5 | 31 | |
| GSE74704 | SDHB | 6390 | 0 | 0 | 20 | |
| TCGA | SDHB | 6390 | 9 | 22 | 65 |
Total number of gains: 35; Total number of losses: 53; Total Number of normals: 400.
Somatic mutations of SDHB:
Generating mutation plots.
Highly correlated genes for SDHB:
Showing top 20/797 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SDHB | GMCL1 | 0.804137 | 3 | 0 | 3 |
| SDHB | TM9SF3 | 0.766446 | 4 | 0 | 3 |
| SDHB | ADAM9 | 0.764544 | 3 | 0 | 3 |
| SDHB | POLR2B | 0.764261 | 3 | 0 | 3 |
| SDHB | PRPF38A | 0.764068 | 4 | 0 | 4 |
| SDHB | JAG1 | 0.759906 | 3 | 0 | 3 |
| SDHB | NTAN1 | 0.751881 | 3 | 0 | 3 |
| SDHB | FRMD6 | 0.750835 | 3 | 0 | 3 |
| SDHB | PKN2 | 0.747249 | 3 | 0 | 3 |
| SDHB | FAM171B | 0.73932 | 3 | 0 | 3 |
| SDHB | DOCK7 | 0.738214 | 4 | 0 | 3 |
| SDHB | PNPLA4 | 0.729391 | 3 | 0 | 3 |
| SDHB | DALRD3 | 0.727489 | 3 | 0 | 3 |
| SDHB | MRPS18A | 0.726363 | 4 | 0 | 4 |
| SDHB | CCR2 | 0.724022 | 3 | 0 | 3 |
| SDHB | TRA2B | 0.723285 | 3 | 0 | 3 |
| SDHB | LEMD3 | 0.722631 | 3 | 0 | 3 |
| SDHB | TM2D2 | 0.721032 | 3 | 0 | 3 |
| SDHB | CIB1 | 0.719474 | 5 | 0 | 4 |
| SDHB | PCMTD2 | 0.716966 | 3 | 0 | 3 |
For details and further investigation, click here
