| Full name: C-C motif chemokine ligand 19 | Alias Symbol: ELC|MIP-3b|exodus-3|CKb11 | ||
| Type: protein-coding gene | Cytoband: 9p13.3 | ||
| Entrez ID: 6363 | HGNC ID: HGNC:10617 | Ensembl Gene: ENSG00000172724 | OMIM ID: 602227 |
| Drug and gene relationship at DGIdb | |||
CCL19 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04062 | Chemokine signaling pathway | |
| hsa04064 | NF-kappa B signaling pathway |
Expression of CCL19:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CCL19 | 6363 | 210072_at | -0.8402 | 0.6174 | |
| GSE20347 | CCL19 | 6363 | 210072_at | -0.1635 | 0.7198 | |
| GSE23400 | CCL19 | 6363 | 210072_at | -0.3814 | 0.0549 | |
| GSE26886 | CCL19 | 6363 | 210072_at | -0.4406 | 0.4160 | |
| GSE29001 | CCL19 | 6363 | 210072_at | 0.1407 | 0.8266 | |
| GSE38129 | CCL19 | 6363 | 210072_at | -0.3788 | 0.4148 | |
| GSE45670 | CCL19 | 6363 | 210072_at | -1.3694 | 0.0572 | |
| GSE53622 | CCL19 | 6363 | 77796 | -0.7426 | 0.0000 | |
| GSE53624 | CCL19 | 6363 | 77796 | -1.1930 | 0.0000 | |
| GSE63941 | CCL19 | 6363 | 210072_at | 0.0705 | 0.6058 | |
| GSE77861 | CCL19 | 6363 | 210072_at | 0.1854 | 0.4061 | |
| GSE97050 | CCL19 | 6363 | A_23_P123853 | 0.2931 | 0.3083 | |
| SRP064894 | CCL19 | 6363 | RNAseq | -0.4068 | 0.4143 | |
| SRP133303 | CCL19 | 6363 | RNAseq | -1.9304 | 0.0000 | |
| SRP159526 | CCL19 | 6363 | RNAseq | -1.1248 | 0.3124 | |
| SRP219564 | CCL19 | 6363 | RNAseq | -0.8167 | 0.3920 | |
| TCGA | CCL19 | 6363 | RNAseq | -0.3995 | 0.4312 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by CCL19 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CCL19:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CCL19 | 6363 | 4 | 13 | 13 | |
| GSE20123 | CCL19 | 6363 | 4 | 13 | 13 | |
| GSE43470 | CCL19 | 6363 | 3 | 10 | 30 | |
| GSE46452 | CCL19 | 6363 | 6 | 15 | 38 | |
| GSE47630 | CCL19 | 6363 | 1 | 20 | 19 | |
| GSE54993 | CCL19 | 6363 | 6 | 0 | 64 | |
| GSE54994 | CCL19 | 6363 | 6 | 12 | 35 | |
| GSE60625 | CCL19 | 6363 | 0 | 0 | 11 | |
| GSE74703 | CCL19 | 6363 | 2 | 7 | 27 | |
| GSE74704 | CCL19 | 6363 | 0 | 11 | 9 | |
| TCGA | CCL19 | 6363 | 16 | 44 | 36 |
Total number of gains: 48; Total number of losses: 145; Total Number of normals: 295.
Somatic mutations of CCL19:
Generating mutation plots.
Highly correlated genes for CCL19:
Showing top 20/222 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CCL19 | P2RY8 | 0.793364 | 4 | 0 | 4 |
| CCL19 | CHRDL2 | 0.724957 | 3 | 0 | 3 |
| CCL19 | ADAMDEC1 | 0.724422 | 3 | 0 | 3 |
| CCL19 | C1orf162 | 0.710464 | 4 | 0 | 4 |
| CCL19 | CD84 | 0.702677 | 5 | 0 | 5 |
| CCL19 | CSF2RB | 0.699133 | 8 | 0 | 8 |
| CCL19 | CD226 | 0.688468 | 3 | 0 | 3 |
| CCL19 | RGS18 | 0.677912 | 4 | 0 | 4 |
| CCL19 | GZMA | 0.670635 | 3 | 0 | 3 |
| CCL19 | CD48 | 0.668607 | 7 | 0 | 6 |
| CCL19 | LTB | 0.664092 | 11 | 0 | 8 |
| CCL19 | ELMO1 | 0.662143 | 5 | 0 | 4 |
| CCL19 | GIMAP7 | 0.661254 | 8 | 0 | 7 |
| CCL19 | TNFSF13 | 0.650574 | 3 | 0 | 3 |
| CCL19 | VPS53 | 0.649558 | 3 | 0 | 3 |
| CCL19 | HLA-DMA | 0.648408 | 7 | 0 | 5 |
| CCL19 | PIGS | 0.64639 | 3 | 0 | 3 |
| CCL19 | IRF8 | 0.644594 | 9 | 0 | 6 |
| CCL19 | ECSCR | 0.644367 | 5 | 0 | 5 |
| CCL19 | BATF3 | 0.643807 | 3 | 0 | 3 |
For details and further investigation, click here
