| Full name: C-C motif chemokine ligand 8 | Alias Symbol: MCP-2|HC14 | ||
| Type: protein-coding gene | Cytoband: 17q12 | ||
| Entrez ID: 6355 | HGNC ID: HGNC:10635 | Ensembl Gene: ENSG00000108700 | OMIM ID: 602283 |
| Drug and gene relationship at DGIdb | |||
CCL8 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04062 | Chemokine signaling pathway |
Expression of CCL8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CCL8 | 6355 | 214038_at | 0.2074 | 0.8068 | |
| GSE20347 | CCL8 | 6355 | 214038_at | 1.0384 | 0.0100 | |
| GSE23400 | CCL8 | 6355 | 214038_at | 0.2928 | 0.0027 | |
| GSE26886 | CCL8 | 6355 | 214038_at | 0.1788 | 0.8039 | |
| GSE29001 | CCL8 | 6355 | 214038_at | 1.0906 | 0.1001 | |
| GSE38129 | CCL8 | 6355 | 214038_at | 0.5546 | 0.2570 | |
| GSE45670 | CCL8 | 6355 | 214038_at | -0.0452 | 0.9589 | |
| GSE53622 | CCL8 | 6355 | 83270 | 0.4200 | 0.1519 | |
| GSE53624 | CCL8 | 6355 | 83270 | 0.9195 | 0.0018 | |
| GSE63941 | CCL8 | 6355 | 214038_at | -3.8580 | 0.0000 | |
| GSE77861 | CCL8 | 6355 | 214038_at | 0.2701 | 0.1681 | |
| GSE97050 | CCL8 | 6355 | A_23_P207456 | 0.4468 | 0.2017 | |
| SRP133303 | CCL8 | 6355 | RNAseq | 0.8798 | 0.0729 | |
| TCGA | CCL8 | 6355 | RNAseq | 0.7574 | 0.0474 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by CCL8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CCL8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CCL8 | 6355 | 5 | 1 | 24 | |
| GSE20123 | CCL8 | 6355 | 5 | 1 | 24 | |
| GSE43470 | CCL8 | 6355 | 1 | 2 | 40 | |
| GSE46452 | CCL8 | 6355 | 34 | 0 | 25 | |
| GSE47630 | CCL8 | 6355 | 7 | 1 | 32 | |
| GSE54993 | CCL8 | 6355 | 3 | 3 | 64 | |
| GSE54994 | CCL8 | 6355 | 8 | 6 | 39 | |
| GSE60625 | CCL8 | 6355 | 4 | 0 | 7 | |
| GSE74703 | CCL8 | 6355 | 1 | 1 | 34 | |
| GSE74704 | CCL8 | 6355 | 3 | 1 | 16 | |
| TCGA | CCL8 | 6355 | 20 | 9 | 67 |
Total number of gains: 91; Total number of losses: 25; Total Number of normals: 372.
Somatic mutations of CCL8:
Generating mutation plots.
Highly correlated genes for CCL8:
Showing top 20/727 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CCL8 | CCDC102B | 0.750526 | 4 | 0 | 4 |
| CCL8 | MGAT5 | 0.749482 | 3 | 0 | 3 |
| CCL8 | ST6GALNAC3 | 0.745986 | 3 | 0 | 3 |
| CCL8 | RBPJ | 0.741237 | 3 | 0 | 3 |
| CCL8 | C19orf38 | 0.729713 | 3 | 0 | 3 |
| CCL8 | EGFLAM | 0.723347 | 3 | 0 | 3 |
| CCL8 | DOK6 | 0.72023 | 3 | 0 | 3 |
| CCL8 | FCGR3A | 0.715808 | 3 | 0 | 3 |
| CCL8 | TMEM181 | 0.705953 | 3 | 0 | 3 |
| CCL8 | CLC | 0.702329 | 3 | 0 | 3 |
| CCL8 | RGS18 | 0.702012 | 5 | 0 | 4 |
| CCL8 | CD163 | 0.694443 | 10 | 0 | 10 |
| CCL8 | RRM2B | 0.689514 | 4 | 0 | 4 |
| CCL8 | SLC15A4 | 0.686525 | 3 | 0 | 3 |
| CCL8 | SVEP1 | 0.686396 | 6 | 0 | 5 |
| CCL8 | HMCN1 | 0.684953 | 4 | 0 | 3 |
| CCL8 | C20orf194 | 0.683042 | 3 | 0 | 3 |
| CCL8 | ZBED6 | 0.682888 | 3 | 0 | 3 |
| CCL8 | PEAK1 | 0.680012 | 4 | 0 | 3 |
| CCL8 | CCL3 | 0.679317 | 4 | 0 | 4 |
For details and further investigation, click here
