| Full name: interleukin 15 receptor subunit alpha | Alias Symbol: CD215|IL-15RA | ||
| Type: protein-coding gene | Cytoband: 10p15.1 | ||
| Entrez ID: 3601 | HGNC ID: HGNC:5978 | Ensembl Gene: ENSG00000134470 | OMIM ID: 601070 |
| Drug and gene relationship at DGIdb | |||
IL15RA involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04630 | Jak-STAT signaling pathway |
Expression of IL15RA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IL15RA | 3601 | 207375_s_at | 0.1345 | 0.8205 | |
| GSE20347 | IL15RA | 3601 | 207375_s_at | 0.4917 | 0.0044 | |
| GSE23400 | IL15RA | 3601 | 207375_s_at | 0.2329 | 0.0001 | |
| GSE26886 | IL15RA | 3601 | 207375_s_at | 1.0043 | 0.0003 | |
| GSE29001 | IL15RA | 3601 | 207375_s_at | 0.4668 | 0.0104 | |
| GSE38129 | IL15RA | 3601 | 207375_s_at | 0.4379 | 0.0142 | |
| GSE45670 | IL15RA | 3601 | 207375_s_at | 0.4289 | 0.0847 | |
| GSE53622 | IL15RA | 3601 | 68848 | 0.8063 | 0.0000 | |
| GSE53624 | IL15RA | 3601 | 68848 | 0.7269 | 0.0000 | |
| GSE63941 | IL15RA | 3601 | 207375_s_at | -1.4389 | 0.0546 | |
| GSE77861 | IL15RA | 3601 | 207375_s_at | 0.3183 | 0.0875 | |
| GSE97050 | IL15RA | 3601 | A_33_P3399263 | 0.4746 | 0.2427 | |
| SRP007169 | IL15RA | 3601 | RNAseq | 0.7657 | 0.1643 | |
| SRP064894 | IL15RA | 3601 | RNAseq | 0.1894 | 0.4547 | |
| SRP133303 | IL15RA | 3601 | RNAseq | 0.3738 | 0.1509 | |
| SRP159526 | IL15RA | 3601 | RNAseq | -0.1783 | 0.6688 | |
| SRP193095 | IL15RA | 3601 | RNAseq | 0.7708 | 0.0004 | |
| SRP219564 | IL15RA | 3601 | RNAseq | 0.9600 | 0.0111 | |
| TCGA | IL15RA | 3601 | RNAseq | 0.1447 | 0.1728 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by IL15RA expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IL15RA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IL15RA | 3601 | 6 | 7 | 17 | |
| GSE20123 | IL15RA | 3601 | 6 | 6 | 18 | |
| GSE43470 | IL15RA | 3601 | 3 | 6 | 34 | |
| GSE46452 | IL15RA | 3601 | 2 | 14 | 43 | |
| GSE47630 | IL15RA | 3601 | 5 | 15 | 20 | |
| GSE54993 | IL15RA | 3601 | 11 | 0 | 59 | |
| GSE54994 | IL15RA | 3601 | 4 | 10 | 39 | |
| GSE60625 | IL15RA | 3601 | 0 | 0 | 11 | |
| GSE74703 | IL15RA | 3601 | 2 | 4 | 30 | |
| GSE74704 | IL15RA | 3601 | 1 | 5 | 14 | |
| TCGA | IL15RA | 3601 | 20 | 24 | 52 |
Total number of gains: 60; Total number of losses: 91; Total Number of normals: 337.
Somatic mutations of IL15RA:
Generating mutation plots.
Highly correlated genes for IL15RA:
Showing top 20/366 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IL15RA | TSPO2 | 0.780146 | 3 | 0 | 3 |
| IL15RA | MPP3 | 0.750307 | 3 | 0 | 3 |
| IL15RA | DNLZ | 0.742524 | 3 | 0 | 3 |
| IL15RA | P4HA2 | 0.72491 | 3 | 0 | 3 |
| IL15RA | FBRSL1 | 0.72151 | 3 | 0 | 3 |
| IL15RA | TDRD9 | 0.716487 | 3 | 0 | 3 |
| IL15RA | PHF21A | 0.709413 | 3 | 0 | 3 |
| IL15RA | EPYC | 0.692869 | 3 | 0 | 3 |
| IL15RA | HAUS8 | 0.67353 | 4 | 0 | 4 |
| IL15RA | IFITM1 | 0.672249 | 9 | 0 | 8 |
| IL15RA | GNLY | 0.666315 | 11 | 0 | 10 |
| IL15RA | HTRA4 | 0.662233 | 5 | 0 | 4 |
| IL15RA | RFX8 | 0.659905 | 3 | 0 | 3 |
| IL15RA | KIF26B | 0.652715 | 5 | 0 | 4 |
| IL15RA | TMEM68 | 0.647733 | 3 | 0 | 3 |
| IL15RA | ARHGAP21 | 0.645014 | 5 | 0 | 5 |
| IL15RA | FCER1G | 0.64036 | 10 | 0 | 9 |
| IL15RA | SLA2 | 0.640088 | 4 | 0 | 3 |
| IL15RA | ADAMTS6 | 0.639809 | 4 | 0 | 3 |
| IL15RA | BATF2 | 0.633862 | 7 | 0 | 6 |
For details and further investigation, click here
