| Full name: indoleamine 2,3-dioxygenase 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 8p11.21 | ||
| Entrez ID: 3620 | HGNC ID: HGNC:6059 | Ensembl Gene: ENSG00000131203 | OMIM ID: 147435 |
| Drug and gene relationship at DGIdb | |||
Expression of IDO1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IDO1 | 3620 | 210029_at | 0.7207 | 0.5250 | |
| GSE20347 | IDO1 | 3620 | 210029_at | 0.8858 | 0.0488 | |
| GSE23400 | IDO1 | 3620 | 210029_at | 0.3301 | 0.0173 | |
| GSE26886 | IDO1 | 3620 | 210029_at | -0.3680 | 0.5694 | |
| GSE29001 | IDO1 | 3620 | 210029_at | 0.3802 | 0.2171 | |
| GSE38129 | IDO1 | 3620 | 210029_at | 0.7318 | 0.0159 | |
| GSE45670 | IDO1 | 3620 | 210029_at | 1.3069 | 0.0289 | |
| GSE53622 | IDO1 | 3620 | 60567 | 1.6100 | 0.0000 | |
| GSE53624 | IDO1 | 3620 | 60567 | 1.3762 | 0.0000 | |
| GSE63941 | IDO1 | 3620 | 210029_at | 0.3820 | 0.6633 | |
| GSE77861 | IDO1 | 3620 | 210029_at | -0.1246 | 0.3509 | |
| GSE97050 | IDO1 | 3620 | A_23_P112026 | 1.3082 | 0.2358 | |
| SRP007169 | IDO1 | 3620 | RNAseq | 1.9449 | 0.0095 | |
| SRP064894 | IDO1 | 3620 | RNAseq | 1.4275 | 0.0004 | |
| SRP133303 | IDO1 | 3620 | RNAseq | 4.0693 | 0.0000 | |
| SRP159526 | IDO1 | 3620 | RNAseq | 1.1545 | 0.2087 | |
| SRP193095 | IDO1 | 3620 | RNAseq | 2.1316 | 0.0000 | |
| SRP219564 | IDO1 | 3620 | RNAseq | 4.2667 | 0.0000 | |
| TCGA | IDO1 | 3620 | RNAseq | 1.1718 | 0.0003 |
Upregulated datasets: 9; Downregulated datasets: 0.
Survival by IDO1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IDO1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IDO1 | 3620 | 10 | 4 | 16 | |
| GSE20123 | IDO1 | 3620 | 10 | 4 | 16 | |
| GSE43470 | IDO1 | 3620 | 7 | 6 | 30 | |
| GSE46452 | IDO1 | 3620 | 20 | 5 | 34 | |
| GSE47630 | IDO1 | 3620 | 22 | 1 | 17 | |
| GSE54993 | IDO1 | 3620 | 2 | 16 | 52 | |
| GSE54994 | IDO1 | 3620 | 19 | 8 | 26 | |
| GSE60625 | IDO1 | 3620 | 3 | 0 | 8 | |
| GSE74703 | IDO1 | 3620 | 7 | 5 | 24 | |
| GSE74704 | IDO1 | 3620 | 9 | 1 | 10 | |
| TCGA | IDO1 | 3620 | 35 | 23 | 38 |
Total number of gains: 144; Total number of losses: 73; Total Number of normals: 271.
Somatic mutations of IDO1:
Generating mutation plots.
Highly correlated genes for IDO1:
Showing top 20/192 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IDO1 | CXCL11 | 0.707725 | 12 | 0 | 11 |
| IDO1 | CXCL9 | 0.707244 | 11 | 0 | 10 |
| IDO1 | GBP4 | 0.696535 | 8 | 0 | 8 |
| IDO1 | CXCL10 | 0.693505 | 12 | 0 | 11 |
| IDO1 | GZMB | 0.686163 | 11 | 0 | 10 |
| IDO1 | USP41 | 0.677022 | 3 | 0 | 3 |
| IDO1 | SLC51A | 0.671622 | 3 | 0 | 3 |
| IDO1 | IL4I1 | 0.662241 | 5 | 0 | 4 |
| IDO1 | UBE2L6 | 0.659807 | 11 | 0 | 11 |
| IDO1 | C2 | 0.65409 | 8 | 0 | 7 |
| IDO1 | CCR5 | 0.6539 | 9 | 0 | 8 |
| IDO1 | EPSTI1 | 0.651728 | 7 | 0 | 7 |
| IDO1 | TFEC | 0.641546 | 10 | 0 | 9 |
| IDO1 | CD209 | 0.638539 | 3 | 0 | 3 |
| IDO1 | GBP5 | 0.636351 | 8 | 0 | 7 |
| IDO1 | GNLY | 0.632232 | 10 | 0 | 8 |
| IDO1 | SIGLEC12 | 0.62321 | 3 | 0 | 3 |
| IDO1 | IL12RB1 | 0.622644 | 7 | 0 | 5 |
| IDO1 | IL2RB | 0.620955 | 11 | 0 | 9 |
| IDO1 | CFB | 0.618888 | 8 | 0 | 6 |
For details and further investigation, click here
