| Full name: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like | Alias Symbol: MGC72244 | ||
| Type: protein-coding gene | Cytoband: 4q13.3 | ||
| Entrez ID: 441024 | HGNC ID: HGNC:31865 | Ensembl Gene: ENSG00000163738 | OMIM ID: 614047 |
| Drug and gene relationship at DGIdb | |||
Expression of MTHFD2L:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MTHFD2L | 441024 | 238762_at | 0.2817 | 0.6787 | |
| GSE20347 | MTHFD2L | 441024 | 220346_at | 0.0213 | 0.9473 | |
| GSE23400 | MTHFD2L | 441024 | 220346_at | 0.0591 | 0.1104 | |
| GSE26886 | MTHFD2L | 441024 | 238762_at | 0.7923 | 0.0134 | |
| GSE29001 | MTHFD2L | 441024 | 220346_at | -0.1729 | 0.6930 | |
| GSE38129 | MTHFD2L | 441024 | 220346_at | -0.0741 | 0.7633 | |
| GSE45670 | MTHFD2L | 441024 | 238762_at | 0.2226 | 0.3670 | |
| GSE53622 | MTHFD2L | 441024 | 21199 | -0.2399 | 0.0344 | |
| GSE53624 | MTHFD2L | 441024 | 21199 | -0.3333 | 0.0022 | |
| GSE63941 | MTHFD2L | 441024 | 238762_at | 0.7105 | 0.4946 | |
| GSE77861 | MTHFD2L | 441024 | 238762_at | -0.2024 | 0.6622 | |
| GSE97050 | MTHFD2L | 441024 | A_33_P3366258 | 0.4246 | 0.2957 | |
| SRP007169 | MTHFD2L | 441024 | RNAseq | -0.7722 | 0.0856 | |
| SRP008496 | MTHFD2L | 441024 | RNAseq | -0.6562 | 0.0286 | |
| SRP064894 | MTHFD2L | 441024 | RNAseq | -0.1051 | 0.5892 | |
| SRP133303 | MTHFD2L | 441024 | RNAseq | 0.1510 | 0.5099 | |
| SRP159526 | MTHFD2L | 441024 | RNAseq | 0.0869 | 0.7932 | |
| SRP193095 | MTHFD2L | 441024 | RNAseq | -0.0612 | 0.6118 | |
| SRP219564 | MTHFD2L | 441024 | RNAseq | 0.5264 | 0.3592 | |
| TCGA | MTHFD2L | 441024 | RNAseq | -0.0701 | 0.4489 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by MTHFD2L expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MTHFD2L:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MTHFD2L | 441024 | 2 | 9 | 19 | |
| GSE20123 | MTHFD2L | 441024 | 2 | 9 | 19 | |
| GSE43470 | MTHFD2L | 441024 | 0 | 13 | 30 | |
| GSE46452 | MTHFD2L | 441024 | 3 | 34 | 22 | |
| GSE47630 | MTHFD2L | 441024 | 1 | 19 | 20 | |
| GSE54993 | MTHFD2L | 441024 | 7 | 0 | 63 | |
| GSE54994 | MTHFD2L | 441024 | 1 | 9 | 43 | |
| GSE60625 | MTHFD2L | 441024 | 0 | 0 | 11 | |
| GSE74703 | MTHFD2L | 441024 | 0 | 11 | 25 | |
| GSE74704 | MTHFD2L | 441024 | 2 | 5 | 13 | |
| TCGA | MTHFD2L | 441024 | 19 | 28 | 49 |
Total number of gains: 37; Total number of losses: 137; Total Number of normals: 314.
Somatic mutations of MTHFD2L:
Generating mutation plots.
Highly correlated genes for MTHFD2L:
Showing top 20/102 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MTHFD2L | CD38 | 0.743383 | 3 | 0 | 3 |
| MTHFD2L | FUCA2 | 0.677854 | 3 | 0 | 3 |
| MTHFD2L | XAF1 | 0.671453 | 3 | 0 | 3 |
| MTHFD2L | NAIP | 0.669315 | 3 | 0 | 3 |
| MTHFD2L | NOP58 | 0.64563 | 4 | 0 | 3 |
| MTHFD2L | SOD2 | 0.64527 | 3 | 0 | 3 |
| MTHFD2L | AKAP5 | 0.64306 | 3 | 0 | 3 |
| MTHFD2L | VCPKMT | 0.643016 | 3 | 0 | 3 |
| MTHFD2L | MASTL | 0.642316 | 3 | 0 | 3 |
| MTHFD2L | TTF1 | 0.641871 | 3 | 0 | 3 |
| MTHFD2L | EIF3C | 0.631717 | 3 | 0 | 3 |
| MTHFD2L | CHD1 | 0.621376 | 4 | 0 | 4 |
| MTHFD2L | CCDC59 | 0.620952 | 4 | 0 | 4 |
| MTHFD2L | MRPL1 | 0.620354 | 4 | 0 | 3 |
| MTHFD2L | NADK2 | 0.609963 | 3 | 0 | 3 |
| MTHFD2L | ZNF141 | 0.609627 | 4 | 0 | 3 |
| MTHFD2L | SRP72 | 0.606376 | 4 | 0 | 4 |
| MTHFD2L | SAR1A | 0.603703 | 5 | 0 | 3 |
| MTHFD2L | DPY19L4 | 0.602956 | 3 | 0 | 3 |
| MTHFD2L | EXOSC8 | 0.600148 | 5 | 0 | 4 |
For details and further investigation, click here
